Search Results - "García León, Annabel"

Phytosterol‐mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor by Cedó, Lídia, Santos, David, Ludwig, Iziar A., Silvennoinen, Reija, García‐León, Annabel, Kaipiainen, Leena, Carbó, José M., Valledor, Annabel F., Gylling, Helena, Motilva, Maria‐José, Kovanen, Petri T., Lee‐Rueckert, Miriam, Blanco‐Vaca, Francisco, Escolà‐Gil, Joan Carles

“…Scope Previous studies have proposed that phytosterols activate liver X receptors (LXR) in the intestine, thereby reducing intestinal cholesterol absorption…”
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Consumption of polyunsaturated fat improves the saturated fatty acid‐mediated impairment of HDL antioxidant potential by Cedó, Lídia, Metso, Jari, Santos, David, Sánchez‐Quesada, Jose Luís, Julve, Josep, García‐León, Annabel, Mora‐Brugués, Josefina, Jauhiainen, Matti, Blanco‐Vaca, Francisco, Escolà‐Gil, Joan Carles

“…SCOPE: The present study aimed to compare the effects of diets containing high‐fat, high‐cholesterol and saturated fatty acids (HFHC‐SFA) and…”
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Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report by Martínez-López, Diego, Cedó, Lídia, Metso, Jari, Burillo, Elena, García-León, Annabel, Canyelles, Marina, Lindholt, Jes S, Torres-Fonseca, Monica, Blanco-Colio, Luis Miguel, Vázquez, Jesús, Blanco-Vaca, Francisco, Jauhiainen, Matti, Martín-Ventura, Jose Luis, Escolà-Gil, Joan Carles

“…Objective- The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function…”
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Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models by Medina-Gutiérrez, Esperanza, García-León, Annabel, Gallardo, Alberto, Álamo, Patricia, Alba-Castellón, Lorena, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon

“…Patients with advanced endometrial cancer (EC) show poor outcomes. Thus, the development of new therapeutic approaches to prevent metastasis development in…”
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Paradoxical cell targeting of calreticulin-empowered, protein-only nanoparticles by Parladé, Eloi, García-Leon, Annabel, Voltà-Durán, Eric, Unzueta, Ugutz, Mangues, Ramon, Casanova, Isolda, Villaverde, Antonio, Vázquez, Esther

“…[Display omitted] Surface-exposed calreticulin (CRT) serves as a crucial cell damage-associated molecular pattern for immunogenic apoptosis, by generating an…”
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A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice by Falgàs, Aïda, Garcia-León, Annabel, Núñez, Yáiza, Serna, Naroa, Sánchez-Garcia, Laura, Unzueta, Ugutz, Voltà-Durán, Eric, Aragó, Marc, Álamo, Patricia, Alba-Castellón, Lorena, Sierra, Jorge, Gallardo, Alberto, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Casanova, Isolda

“…High rates of relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients and life-threatening side effects associated with immunochemotherapy make…”
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ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer by Cedó, Lídia, García-León, Annabel, Baila-Rueda, Lucía, Santos, David, Grijalva, Victor, Martínez-Cignoni, Melanie Raquel, Carbó, José M., Metso, Jari, López-Vilaró, Laura, Zorzano, Antonio, Valledor, Annabel F., Cenarro, Ana, Jauhiainen, Matti, Lerma, Enrique, Fogelman, Alan M., Reddy, Srinivasa T., Escolà-Gil, Joan Carles, Blanco-Vaca, Francisco

“…Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported…”
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Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials by Serna, Naroa, Falgàs, Aïda, García-León, Annabel, Unzueta, Ugutz, Núñez, Yáiza, Sánchez-Chardi, Alejandro, Martínez-Torró, Carlos, Mangues, Ramón, Vazquez, Esther, Casanova, Isolda, Villaverde, Antonio

“…The sustained release of small, tumor-targeted cytotoxic drugs is an unmet need in cancer therapies, which usually rely on punctual administration regimens of…”
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T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo by Núñez, Yáiza, Garcia-León, Annabel, Falgàs, Aïda, Serna, Naroa, Sánchez-García, Laura, Garrido, Ana, Sierra, Jorge, Gallardo, Alberto, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda

“…Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to…”
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A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model by Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Aviñó, Anna, Núñez, Yáiza, García-León, Annabel, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Cedó, Lídia, Eritja, Ramon, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon

“…Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying…”
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LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight From Mouse Models by Cedó, Lídia, Metso, Jari, Santos, David, García-León, Annabel, Plana, Núria, Sabate-Soler, Sonia, Rotllan, Noemí, Rivas-Urbina, Andrea, Méndez-Lara, Karen A., Tondo, Mireia, Girona, Josefa, Julve, Josep, Pallarès, Victor, Benitez-Amaro, Aleyda, Llorente-Cortes, Vicenta, Pérez, Antonio, Gómez-Coronado, Diego, Ruotsalainen, Anna-Kaisa, Levonen, Anna-Liisa, Sanchez-Quesada, José Luis, Masana, Luís, Kovanen, Petri T., Jauhiainen, Matti, Lee-Rueckert, Miriam, Blanco-Vaca, Francisco, Escolà-Gil, Joan Carles

“…RATIONALE:The HDL-mediated stimulation of cellular cholesterol efflux initiates the reverse cholesterol pathway from macrophages (m-RCT), which ends in the…”
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Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness by Revilla, Giovanna, Pons, Monica de Pablo, Baila-Rueda, Lucía, García-León, Annabel, Santos, David, Cenarro, Ana, Magalhaes, Marcelo, Blanco, R. M., Moral, Antonio, Ignacio Pérez, José, Sabé, Gerard, González, Cintia, Fuste, Victoria, Lerma, Enrique, Faria, Manuel dos Santos, de Leiva, Alberto, Corcoy, Rosa, Carles Escolà-Gil, Joan, Mato, Eugenia

“…Cholesterol mediates its proliferative and metastatic effects via the metabolite 27-hydroxycholesterol (27-HC), at least in breast and endometrial cancer. We…”
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ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer by Cedó Giné, Lídia, García León, Annabel, Baila Rueda, Lucía, Santos, David, Grijalva, Victor, Martínez Cignoni, Melanie Raquel, Carbo Marques, Jose Maria, Metso, Jari, López Vilaró, Laura, Zorzano Olarte, Antonio, Valledor Fernández, Annabel, Cenarro, Ana, Jauhiainen, Matti, Lerma, Enrique, Fogelman, Alan M, Reddy, Srinivasa T, Escolà i Gil, Joan Carles, Blanco-Vaca, Francisco

“…Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported…”
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ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer by Cedó Giné, Lídia, García León, Annabel, Baila Rueda, Lucía, Santos, David, Grijalva, Victor, Martínez Cignoni, Melanie Raquel, Carbo Marques, Jose Maria, Metso, Jari, López Vilaró, Laura, Zorzano Olarte, Antonio, Valledor Fernández, Annabel, Cenarro, Ana, Jauhiainen, Matti, Lerma, Enrique, Fogelman, Alan M, Reddy, Srinivasa T, Escolà i Gil, Joan Carles, Blanco-Vaca, Francisco

“…Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported…”
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Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis by Fernández-de-Retana, Sofía, Cano-Sarabia, Mary, Marazuela, Paula, Sánchez-Quesada, Jose Luis, Garcia-Leon, Annabel, Montañola, Alex, Montaner, Joan, Maspoch, Daniel, Hernández-Guillamon, Mar

“…Cerebral β-amyloidosis is a major feature of Alzheimer’s disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several…”
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Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm by Martínez-López, Diego, Cedó, Lídia, Metso, Jari, Burillo, Elena, García-León, Annabel, Canyelles, Marina, Lindholt, Jes S, Torres-Fonseca, Monica, Blanco-Colio, Luis Miguel, Vázquez, Jesús M, Blanco-Vaca, Francisco, Jauhiainen, Matti, Martín-Ventura, Jose Luis, Escolà-Gil, Joan Carles

“…OBJECTIVE—The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function…”
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Engineering non-antibody human proteins as efficient scaffolds for selective, receptor-targeted drug delivery by Serna, Naroa, Pallarès, Victor, Unzueta, Ugutz, Garcia-Leon, Annabel, Voltà-Durán, Eric, Sánchez-Chardi, Alejandro, Parladé, Eloi, Rueda, Ariana, Casanova, Isolda, Falgàs, Aïda, Alba-Castellón, Lorena, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramón

“…Self-assembling non-immunoglobulin scaffold proteins are a promising class of nanoscale carriers for drug delivery and interesting alternatives to…”
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