Search Results - "García Closas, Montserrat"

A framework for transcriptome-wide association studies in breast cancer in diverse study populations by Bhattacharya, Arjun, García-Closas, Montserrat, Olshan, Andrew F, Perou, Charles M, Troester, Melissa A, Love, Michael I

“…The relationship between germline genetic variation and breast cancer survival is largely unknown, especially in understudied minority populations who often…”
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The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility by Long, Erping, García-Closas, Montserrat, Chanock, Stephen J., Camargo, M. Constanza, Banovich, Nicholas E., Choi, Jiyeon

“…Tissue-based functional genomics resources including molecular quantitative trait loci datasets lack diversity in ancestry and tissue types and thus are…”
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Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study by YANG, Xiaohong R, SHERMAN, Mark E, ZATONSKI, Witold, CARTUN, Richard, MANDICH, Daniza, RYMKIEWICZ, Grzegorz, LIGAJ, Marcin, LUKASZEK, Stanislaw, KORDEK, Radzisaw, GARCIA-CLOSAS, Montserrat, RIMM, David L, LISSOWSKA, Jolanta, BRINTON, Louise A, PEPLONSKA, Beata, HEWITT, Stephen M, ANDERSON, William F, SZESZENIA -DABROWSKA, Neonila, BARDIN-MIKOLAJCZAK, Alicja

“…Analysis of gene expression data suggests that breast cancers are divisible into molecular subtypes which have distinct clinical features. This study evaluates…”
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A mixed-model approach for powerful testing of genetic associations with cancer risk incorporating tumor characteristics by Zhang, Haoyu, Zhao, Ni, Ahearn, Thomas U, Wheeler, William, García-Closas, Montserrat, Chatterjee, Nilanjan

“…Cancers are routinely classified into subtypes according to various features, including histopathological characteristics and molecular markers. Previous…”
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Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk by Shu, Xiang, Bao, Jiandong, Wu, Lang, Long, Jirong, Shu, Xiao‐Ou, Guo, Xingyi, Yang, Yaohua, Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Andrulis, Irene L., Castelao, Jose E., Dörk, Thilo, Gago‐Dominguez, Manuela, García‐Closas, Montserrat, Giles, Graham G., Lophatananon, Artitaya, Muir, Kenneth, Olsson, Håkan, Rennert, Gadi, Saloustros, Emmanouil, Scott, Rodney J., Southey, Melissa C., Pharoah, Paul D.P., Milne, Roger L., Kraft, Peter, Simard, Jacques, Easton, Douglas F., Zheng, Wei

“…A small number of circulating proteins have been reported to be associated with breast cancer risk, with inconsistent results. Herein, we attempted to identify…”
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Developing and evaluating polygenic risk prediction models for stratified disease prevention by Chatterjee, Nilanjan, Shi, Jianxin, García-Closas, Montserrat

“…Key Points Evaluation of the utility of genetic risk assessment for disease prevention requires the development of models incorporating both genetic and…”
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Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA by Tajuddin, Salman M, Amaral, André F S, Fernández, Agustín F, Rodríguez-Rodero, Sandra, Rodríguez, Ramón María, Moore, Lee E, Tardón, Adonina, Carrato, Alfredo, García-Closas, Montserrat, Silverman, Debra T, Jackson, Brian P, García-Closas, Reina, Cook, Ashley L, Cantor, Kenneth P, Chanock, Stephen, Kogevinas, Manolis, Rothman, Nathaniel, Real, Francisco X, Fraga, Mario F, Malats, Núria

“…Altered DNA methylation has been associated with various diseases. We evaluated the association between levels of methylation in leukocyte DNA at long…”
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Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case–control study by Moore, Lee E, Dr, Pfeiffer, Ruth M, PhD, Poscablo, Cristina, BS, Real, Francisco X, MD, Kogevinas, Manolis, MD, Silverman, Debra, ScD, García-Closas, Reina, MD, Chanock, Stephen, MD, Tardón, Adonina, PhD, Serra, Consol, MD, Carrato, Alfredo, Prof, Dosemeci, Mustafa, PhD, García-Closas, Montserrat, MD, Esteller, Manel, MD, Fraga, Mario, PhD, Rothman, Nathaniel, MD, Malats, Núria, MD

“…Summary Background DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA…”
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Quest markup for developing FAIR questionnaire modules for epidemiologic studies by Russ, Daniel E, Gerlanc, Nicole M, Shen, Brian, Patel, Bhaumik, de González, Amy Berrington, Freedman, Neal D, Cusack, Julie M, Gaudet, Mia M, García-Closas, Montserrat, Almeida, Jonas S

“…Abstract Background Online questionnaires are commonly used to collect information from participants in epidemiological studies. This requires building…”
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Detectible mosaic truncating PPM1D mutations, age and breast cancer risk by Machiela, Mitchell J, Myers, Timothy A, Lyons, Christopher J, Koster, Roelof, Figg, Jr, William D, Colli, Leandro M, Jessop, Lea, Ahearn, Thomas U, Freedman, Neal D, García-Closas, Montserrat, Chanock, Stephen J

“…Mosaic protein truncating variants (PTVs) in the phosphatase, Mg2+/Mn2+dependent 1D (PPM1D) gene in blood-derived DNA have been associated with increased risk…”
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Genetic Variation in the Nucleotide Excision Repair Pathway and Bladder Cancer Risk by GARCIA-CLOSAS, Montserrat, MALATS, Nuria, SERRA, Consol, CARRATO, Alfredo, GARCIA-CLOSAS, Reina, CASTANO-VINYALS, Gemma, CHANOCK, Stephen, YEAGER, Meredith, ROTHMAN, Nathaniel, REAL, Francisco X, WELCH, Robert, KOGEVINAS, Manolis, CHATTERJEE, Nilanjan, PFEIFFER, Ruth, SILVERMAN, Debra, DOSEMECI, Mustafa, TARDON, Adonina

“…Nucleotide excision repair (NER) is critical for protecting against damage from carcinogens in tobacco smoke. We evaluated the influence of common genetic…”
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A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background by García-Closas, Montserrat, Hein, David W, Silverman, Debra, Malats, Núria, Yeager, Meredith, Jacobs, Kevin, Doll, Mark A, Figueroa, Jonine D, Baris, Dalsu, Schwenn, Molly, Kogevinas, Manolis, Johnson, Alison, Chatterjee, Nilanjan, Moore, Lee E, Moeller, Timothy, Real, Francisco X, Chanock, Stephen, Rothman, Nathaniel

“…The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this…”
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Assessment of copy number variation using the Illumina Infinium 1M SNP-array: a comparison of methodological approaches in the Spanish Bladder Cancer/EPICURO study by Marenne, Gaëlle, Rodríguez-Santiago, Benjamín, Closas, Montserrat García, Pérez-Jurado, Luis, Rothman, Nathaniel, Rico, Daniel, Pita, Guillermo, Pisano, David G, Kogevinas, Manolis, Silverman, Debra T, Valencia, Alfonso, Real, Francisco X, Chanock, Stephen J, Génin, Emmanuelle, Malats, Núria

“…High-throughput single nucleotide polymorphism (SNP)-array technologies allow to investigate copy number variants (CNVs) in genome-wide scans and specific…”
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Food, nutrient and heterocyclic amine intake and the risk of bladder cancer by García-Closas, Reina, García-Closas, Montserrat, Kogevinas, Manolis, Malats, Núria, Silverman, Debra, Serra, Consol, Tardón, Adonina, Carrato, Alfredo, Castaño-Vinyals, Gemma, Dosemeci, Mustafa, Moore, Lee, Rothman, Nathaniel, Sinha, Rashmi

“…Abstract Fruit and vegetable intake has been linked to bladder cancer risk; however, evidence for other foods or specific dietary factors is inconclusive. The…”
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Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk by de Maturana, Evangelina López, Ye, Yuanqing, Calle, M Luz, Rothman, Nathaniel, Urrea, Víctor, Kogevinas, Manolis, Petrus, Sandra, Chanock, Stephen J, Tardón, Adonina, García-Closas, Montserrat, González-Neira, Anna, Vellalta, Gemma, Carrato, Alfredo, Navarro, Arcadi, Lorente-Galdós, Belén, Silverman, Debra T, Real, Francisco X, Wu, Xifeng, Malats, Núria

“…The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study…”
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Genetic variation in the TP53 pathway and bladder cancer risk. a comprehensive analysis by Pineda, Silvia, Milne, Roger L, Calle, M Luz, Rothman, Nathaniel, López de Maturana, Evangelina, Herranz, Jesús, Kogevinas, Manolis, Chanock, Stephen J, Tardón, Adonina, Márquez, Mirari, Guey, Lin T, García-Closas, Montserrat, Lloreta, Josep, Baum, Erin, González-Neira, Anna, Carrato, Alfredo, Navarro, Arcadi, Silverman, Debra T, Real, Francisco X, Malats, Núria

“…Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer…”
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Risk of Bladder Cancer Associated with Family History of Cancer: Do Low-Penetrance Polymorphisms Account for the Increase in Risk? by Murta-Nascimento, Cristiane, Silverman, Debra T, Kogevinas, Manolis, García-Closas, Montserrat, Rothman, Nathaniel, Tardón, Adonina, García-Closas, Reina, Serra, Consol, Carrato, Alfredo, Villanueva, Cristina, Dosemeci, Mustafa, Real, Francisco X, Malats, Núria

“…The relationship between family history of cancer in first-degree relatives and risk of bladder cancer was examined in the Spanish Bladder Cancer Study…”
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Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk by García-Closas, Montserrat, Malats, Núria, Real, Francisco X, Yeager, Meredith, Welch, Robert, Silverman, Debra, Kogevinas, Manolis, Dosemeci, Mustafa, Figueroa, Jonine, Chatterjee, Nilanjan, Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Murta-Nascimento, Cristiane, Rothman, Nathaniel, Chanock, Stephen J

“…Common genetic variation could alter the risk for developing bladder cancer. We conducted a large-scale evaluation of single nucleotide polymorphisms (SNPs) in…”
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Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk by Figueroa, Jonine D., Malats, Núria, Rothman, Nathaniel, Real, Francisco X., Silverman, Debra, Kogevinas, Manolis, Chanock, Stephen, Yeager, Meredith, Welch, Robert, Dosemeci, Mustafa, Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Castaño-Vinyals, Gemma, García-Closas, Montserrat

“…The double-strand break DNA repair (DSBR) pathway is implicated in maintaining genomic stability and therefore could affect bladder cancer risk. Here we…”
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Urinary pH, cigarette smoking and bladder cancer risk by ALGUACIL, Juan, KOGEVINAS, Manolis, SERRA, Consol, CARRATO, Alfredo, PFEIFFER, Ruth M, FORTUNY, Joan, SAMANIC, Claudine, ROTHMAN, Nathaniel, SILVERMAN, Debra T, MALATS, Núria, REAL, Francisco X, GARCIA-CLOSAS, Montserrat, TARDON, Adonina, RIVAS, Manuel, TORA, Montserrat, GARCIA-CLOSAS, Reina

“…Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and…”
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