Search Results - "García‐Osta, A"

Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease by Cuadrado‐Tejedor, M, Hervias, I, Ricobaraza, A, Puerta, E, Pérez‐Roldán, JM, García‐Barroso, C, Franco, R, Aguirre, N, García‐Osta, A

“…BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes…”
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Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease by Cuadrado-Tejedor, M, García-Osta, A, Ricobaraza, A, Oyarzabal, J, Franco, R

“…4-phenylbutyrate (PBA) is a small molecule that restores cognitive deficits in animal models of Alzheimer's disease (AD). Although the molecular basis of the…”
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BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons by Frechilla, Diana, García-Osta, Ana, Palacios, Sara, Cenarruzabeitia, Edurne, Del Río, Joaquín

“…In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced…”
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Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease by Ugarte, Ana, Gil-Bea, Francisco, García-Barroso, Carolina, Cedazo-Minguez, Ángel, Ramírez, M. Javier, Franco, Rafael, García-Osta, Ana, Oyarzabal, Julen, Cuadrado-Tejedor, Mar

“…Aims Levels of the cyclic nucleotides guanosine 3′, 5′‐monophosphate (cGMP) or adenosine 3′, 5′‐monophosphate (cAMP) that play important roles in memory…”
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Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease by Cuadrado-Tejedor, M, Garcia-Barroso, C, Sanzhez-Arias, J, Mederos, S, Rabal, O, Ugarte, A, Franco, R, Pascual-Lucas, M, Segura, V, Perea, G, Oyarzabal, J, Garcia-Osta, A

“…Given the implication of histone acetylation in memory processes, histone deacetylase inhibitors (HDACIs) have been postulated as potential modulators of…”
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Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone by Garcı́a-Osta, Ana, Frechilla, Diana, Del Rı́o, Joaquı́n

“…The effect of antipsychotic treatment on basal and phencyclidine (PCP)-induced heat shock protein-70 (hsp70) mRNA expression was studied in the rat striatum…”
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Effect of p‐Chloroamphetamine on 5‐HT1A and 5‐HT7 Serotonin Receptor Expression in Rat Brain by García‐Osta, Ana, Frechilla, Diana, Del Río, Joaquín

“…: The aim of this study was to investigate if p‐chloroamphetamine (PCA), which is neurotoxic to serotonin (5‐HT) nerve terminals, was able to induce, like…”
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Differential Regulation by Methylenedioxymethamphetamine of 5‐Hydroxytryptamine1A Receptor Density and mRNA Expression in Rat Hippocampus, Frontal Cortex, and Brainstem: The Role of Corticosteroids by Aguirre, Norberto, Frechilla, Diana, García‐Osta, Ana, Lasheras, Berta, Del Río, Joaquín

“…: The present study examined the effects of repeated administration to rats of 3,4‐methylenedioxymethamphetamine (MDMA, “Ecstasy”) on 5‐hydroxytryptamine1A…”
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Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum by Frechilla, Diana, Insausti, Ricardo, Ruiz-Golvano, Paula, Garcı́a-Osta, Ana, Rubio, Maria-Paz, Almendral, Jose-Maria, Del Rı́o, Joaquı́n

“…Degeneration of serotonergic fibers in the rat striatum was produced by local administration of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT)…”
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Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease: Reinstatement of cognitive function by sildenafil by Cuadrado-Tejedor, M, Hervias, I, Ricobaraza, A, Puerta, E, Pérez-Roldán, JM, García-Barroso, C, Franco, R, Aguirre, N, García-Osta, A

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Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors by Otano, A, García-Osta, A, Ballaz, S, Frechilla, D, Del Río, J

“…1. Pretraining administration of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT 0.1 mg kg(-1)), a 5-HT(1A) receptor agonist, or buspirone (1 mg kg(-1)), a…”
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Dysregulated Postsynaptic Density and Endocytic Zone in the Amygdala of Human Heroin and Cocaine Abusers by Ökvist, Anna, Fagergren, Pernilla, Whittard, John, Garcia-Osta, Ana, Drakenberg, Katarina, Horvath, Monika Cs, Schmidt, Carl J, Keller, Eva, Bannon, Michael J, Hurd, Yasmin L

“…Background Glutamatergic transmission in the amygdala is hypothesized as an important mediator of stimulus-reward associations contributing to drug-seeking…”
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Sildenafil restores cognitive function without affecting [beta]-amyloid burden in a mouse model of Alzheimer's disease by Cuadrado-Tejedor, M, Hervias, I, Ricobaraza, A, Puerta, E, Perez-Roldan, JM, Garcia-Barroso, C, Franco, R, Aguirre, N, Garcia-Osta, A

“…BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes…”
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Sildenafil restores cognitive function without affecting Delta b-amyloid burden in a mouse model of Alzheimer's disease by Cuadrado-Tejedor, M, Hervias, I, Ricobaraza, A, Puerta, E, Garcia-Barroso, C, Franco, R, Aguirre, N, Garcia-Osta, A

“…Keywords: Alzheimer's disease; p-tau; sildenafil; GSK3 Delta *b; CDK5; BDNF BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling…”
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Effect of p-Chloroamphetamine on 5-HT sub(1A) and 5-HT sub(7) Serotonin Receptor Expression in Rat Brain by Garcia-Osta, A, Frechilla, D, Del Rio, J

“…The aim of this study was to investigate if p-chloroamphetamine (PCA), which is neurotoxic to serotonin (5-HT) nerve terminals, was able to induce, like…”
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Effect of p-chloroamphetamine on 5-HT1A and 5-HT7serotonin receptor expression in rat brain by GARCIA-OSTA, A, FRECHILLA, D, DEL RIO, J

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Facilitation by 8‐OH‐DPAT of passive avoidance performance in rats after inactivation of 5‐HT1A receptors by Otano, Ana, García‐Osta, Ana, Ballaz, Santiago, Frechilla, Diana, Del Río, Joaquín

“…Pretraining administration of 8‐hydroxy‐2‐di‐n‐propylamino‐tetralin (8‐OH‐DPAT 0.1 mg kg−1), a 5‐HT1A receptor agonist, or buspirone (1 mg kg−1), a 5‐HT1A…”
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Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in the rat frontal cortex but not in the hippocampus by Garcı́a-Osta, Ana, Del Rı́o, Joaquı́n, Frechilla, Diana

“…A single administration of either 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) or p-chloroamphetamine (PCA) produced a rapid and marked reduction of…”
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Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT sub(1A) receptors by Otano, A, Garcia-Osta, A, Ballaz, S, Frechilla, D, Del Rio, J

“…Pretraining administration of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT 0.1 mg kg super(-1)), a 5-HT sub(1A) receptor agonist, or buspirone (1 mg kg…”
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Differential regulation by methylenedioxymethamphetamine of 5-hydroxytryptamine sub(1A) receptor density and mRNA expression in rat hippocampus, frontal cortex, and brainstem: The role of corticosteroids by Aguirre, N, Frechilla, D, Garcia-Osta, A, Lasheras, B, Del Rio, J

“…The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine sub(1A)…”
Get full text