Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells

Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells

The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a critical role in the xenobiotic and stress responses. During viral infection, NRF2 can modulate the host metabolism and innate immunity; however, the most common activity of NRF2 in viral diseases is contro...

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Bibliographic Details
Published in:Virus genes Vol. 59; no. 5; pp. 781 - 785
Main Authors: Cervantes, Manuel Adrián Velázquez, Martinez, Julio Angel Vázquez, García, Luis Didider Gonzalez, Ortega, Orestes Lopez, Romero, Haruki Arevalo, Estrada, Araceli Montoya, Castillo, Macario Martínez, Pliego, Arturo Flores, Reyes, Guadalupe León, Repetto, Addy Cecilia Helguera, Cordero, Julio García, Juárez, Moisés León
Format: Journal Article
Language:English
Published: New York Springer US 01-10-2023
Springer Nature B.V
Subjects:
Antibodies
Antioxidants
Biomedical and Life Sciences
Biomedicine
Brief Report
Cells
Enzymes
Fetuses
Homeostasis
Infections
Innate immunity
Medical Microbiology
Oxidative stress
Plant Sciences
Pregnancy
Proteins
Reactive oxygen species
Trophoblasts
Viral diseases
Viral infections
Virology
Zika virus
Oxidative stress
Zika virus
Trophoblast
Placenta
ROS
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Summary:The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a critical role in the xenobiotic and stress responses. During viral infection, NRF2 can modulate the host metabolism and innate immunity; however, the most common activity of NRF2 in viral diseases is controlling reactive oxygen species (ROS). The Zika virus (ZIKV) is involved in a vertical infection in pregnancy, with reported fetal health consequences. However, the possibility that ZIKV regulates NRF2 expression in placental trophoblasts has not been investigated. In this report, we evaluated the upregulation of NRF2 and antioxidant enzymes in a trophoblast-like cell. These findings could help us understand the antioxidant mechanism underlying the ZIKV infection in the placenta during pregnancy.
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ISSN:0920-8569
1572-994X
1572-994X
DOI:10.1007/s11262-023-02014-x