Search Results - "Garbis, Spiros D"

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding by Shin, Chun-Shik, Meng, Shuxia, Garbis, Spiros D., Moradian, Annie, Taylor, Robert W., Sweredoski, Michael J., Lomenick, Brett, Chan, David C.

“…Most mitochondrial precursor polypeptides are imported from the cytosol into the mitochondrion, where they must efficiently undergo folding. Mitochondrial…”
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Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome by Brault, Véronique, Nguyen, Thu Lan, Flores-Gutiérrez, Javier, Iacono, Giovanni, Birling, Marie-Christine, Lalanne, Valérie, Meziane, Hamid, Manousopoulou, Antigoni, Pavlovic, Guillaume, Lindner, Loïc, Selloum, Mohammed, Sorg, Tania, Yu, Eugene, Garbis, Spiros D, Hérault, Yann

“…Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability,…”
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A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers by Hanley, Christopher J, Noble, Fergus, Ward, Matthew, Bullock, Marc, Drifka, Cole, Mellone, Massimiliano, Manousopoulou, Antigoni, Johnston, Harvey E, Hayden, Annette, Thirdborough, Steve, Liu, Yuming, Smith, David M, Mellows, Toby, Kao, W John, Garbis, Spiros D, Mirnezami, Alex, Underwood, Tim J, Eliceiri, Kevin W, Thomas, Gareth J

“…Collagen structure has been shown to influence tumor cell invasion, metastasis and clinical outcome in breast cancer. However, it remains unclear how it…”
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Stable Isotope Analysis of Intact Oxyanions Using Electrospray Quadrupole-Orbitrap Mass Spectrometry by Neubauer, Cajetan, Crémière, Antoine, Wang, Xingchen T, Thiagarajan, Nivedita, Sessions, Alex L, Adkins, Jess F, Dalleska, Nathan F, Turchyn, Alexandra V, Clegg, Josephine A, Moradian, Annie, Sweredoski, Michael J, Garbis, Spiros D, Eiler, John M

“…The stable isotopes of sulfate, nitrate, and phosphate are frequently used to study geobiological processes of the atmosphere, ocean, as well as land…”
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BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1 by Genheden, Maja, Kenney, Justin W, Johnston, Harvey E, Manousopoulou, Antigoni, Garbis, Spiros D, Proud, Christopher G

“…Although the MAP kinase-interacting kinases (MNKs) have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure…”
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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A by Nguyen, Thu Lan, Duchon, Arnaud, Manousopoulou, Antigoni, Loaëc, Nadège, Villiers, Benoît, Pani, Guillaume, Karatas, Meltem, Mechling, Anna E, Harsan, Laura-Adela, Limanton, Emmanuelle, Bazureau, Jean-Pierre, Carreaux, François, Garbis, Spiros D, Meijer, Laurent, Herault, Yann

“…Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here…”
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Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onset by Mournetas, Virginie, Massouridès, Emmanuelle, Dupont, Jean‐Baptiste, Kornobis, Etienne, Polvèche, Hélène, Jarrige, Margot, Dorval, Alan R.L., Gosselin, Maxime R.F., Manousopoulou, Antigoni, Garbis, Spiros D., Górecki, Dariusz C., Pinset, Christian

“…Background Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of approximately 1/5000 male…”
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Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion by Billiard, Fabienne, Karaliota, Sevasti, Wang, Bei, Stellas, Dimitrios, Serafimidis, Ioannis, Manousopoulou, Antigoni, Koutmani, Yiassemi, Ninou, Elpiniki, Golubov, Jacquelynn, DaNave, Amanda, Tsakanikas, Panagiotis, Xin, Yurong, Zhang, Wen, Sleeman, Matthew, Yancopoulos, George D., Murphy, Andrew J., Garbis, Spiros D., Karalis, Katia, Skokos, Dimitris

“…Although Notch signaling has been proposed as a therapeutic target for type-2 diabetes, liver steatosis, and atherosclerosis, its direct effect on pancreatic…”
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The Effect of Prenatal Food Restriction on Brain Proteome in Appropriately Grown and Growth Restricted Male Wistar Rats by Potiris, Anastasios, Manousopoulou, Antigoni, Zouridis, Andreas, Sarli, Polyxeni-Maria, Pervanidou, Panagiota, Eliades, George, Perrea, Despina N, Deligeoroglou, Efthymios, Garbis, Spiros D, Eleftheriades, Makarios

“…Fetal growth restriction (FGR) has been associated with a higher risk of developing adverse perinatal outcomes and distinct neurodevelopmental and…”
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Biomarker Discovery in Low-Grade Breast Cancer Using Isobaric Stable Isotope Tags and Two-Dimensional Liquid Chromatography-Tandem Mass Spectrometry (iTRAQ-2DLC-MS/MS) Based Quantitative Proteomic Analysis by Bouchal, Pavel, Roumeliotis, Theodoros, Hrstka, Roman, Nenutil, Rudolf, Vojtesek, Borivoj, Garbis, Spiros D

“…The present pilot study constitutes a proof-of-principle in the use of a quantitative LC-MS/MS based proteomic method for the comparative analysis of…”
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Impact of Maternal Food Restriction on Heart Proteome in Appropriately Grown and Growth-Restricted Wistar-Rat Offspring by Zouridis, Andreas, Manousopoulou, Antigoni, Potiris, Anastasios, Sarli, Polyxeni-Maria, Aravantinos, Leon, Pervanidou, Panagiota, Deligeoroglou, Efthymios, Garbis, Spiros D, Eleftheriades, Makarios

“…Fetal growth restriction is associated with increased postnatal cardiovascular morbidity. The alterations in heart physiology and structure caused by in utero…”
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Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study by Zeidan, Bashar, Manousopoulou, Antigoni, Garay-Baquero, Diana J, White, Cory H, Larkin, Samantha E T, Potter, Kathleen N, Roumeliotis, Theodoros I, Papachristou, Evangelia K, Copson, Ellen, Cutress, Ramsey I, Beers, Stephen A, Eccles, Diana, Townsend, Paul A, Garbis, Spiros D

“…Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer…”
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Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides by Cam, Morgane, Durieu, Emilie, Bodin, Marion, Manousopoulou, Antigoni, Koslowski, Svenja, Vasylieva, Natalia, Barnych, Bogdan, Hammock, Bruce D, Bohl, Bettina, Koch, Philipp, Omori, Chiori, Yamamoto, Kazuo, Hata, Saori, Suzuki, Toshiharu, Karg, Frank, Gizzi, Patrick, Erakovic Haber, Vesna, Bencetic Mihaljevic, Vlatka, Tavcar, Branka, Portelius, Erik, Pannee, Josef, Blennow, Kaj, Zetterberg, Henrik, Garbis, Spiros D, Auvray, Pierrick, Gerber, Hermeto, Fraering, Jeremy, Fraering, Patrick C, Meijer, Laurent

“…Generation of amyloid-β peptides (Aβs) by proteolytic cleavage of the amyloid-β protein precursor (AβPP), especially increased production of Aβ42/Aβ43 over…”
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Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition by Sarli, Polyxeni-Maria, Manousopoulou, Antigoni, Efthymiou, Elias, Zouridis, Andreas, Potiris, Anastasios, Pervanidou, Panagiota, Panoulis, Konstantinos, Vlahos, Nikolaos, Deligeoroglou, Efthymios, Garbis, Spiros D, Eleftheriades, Makarios

“…Fetal growth restriction (FGR) has been associated with adverse perinatal outcomes and epigenetic modifications that impact gene expression leading to…”
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Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis by Garay-Baquero, Diana J, White, Cory H, Walker, Naomi F, Tebruegge, Marc, Schiff, Hannah F, Ugarte-Gil, Cesar, Morris-Jones, Stephen, Marshall, Ben G, Manousopoulou, Antigoni, Adamson, John, Vallejo, Andres F, Bielecka, Magdalena K, Wilkinson, Robert J, Tezera, Liku B, Woelk, Christopher H, Garbis, Spiros D, Elkington, Paul

“…BACKGROUNDTuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed to discover…”
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The Shotgun Proteomic Study of the Human ThinPrep Cervical Smear Using iTRAQ Mass-Tagging and 2D LC-FT-Orbitrap-MS: The Detection of the Human Papillomavirus at the Protein Level by Papachristou, Evaggelia K, Roumeliotis, Theodoros I, Chrysagi, Argyro, Trigoni, Chrysanthi, Charvalos, Ekatherina, Townsend, Paul A, Pavlakis, Kitty, Garbis, Spiros D

“…The ThinPrep cervical smear is widely used in clinical practice for the cytological and molecular screening against abnormal cells and Human Papillomavirus…”
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Specific Triazine Herbicides Induce Amyloid-β42 Production by Portelius, Erik, Durieu, Emilie, Bodin, Marion, Cam, Morgane, Pannee, Josef, Leuxe, Charlotte, Mabondzo, Aloϊse, Oumata, Nassima, Galons, Hervé, Lee, Jung Yeol, Chang, Young-Tae, Stϋber, Kathrin, Koch, Philipp, Fontaine, Gaëlle, Potier, Marie-Claude, Manousopoulou, Antigoni, Garbis, Spiros D, Covaci, Adrian, Van Dam, Debby, De Deyn, Peter, Karg, Frank, Flajolet, Marc, Omori, Chiori, Hata, Saori, Suzuki, Toshiharu, Blennow, Kaj, Zetterberg, Henrik, Meijer, Laurent

“…Proteolytic cleavage of the amyloid-β protein precursor (AβPP) by secretases leads to extracellular release of amyloid-β (Aβ) peptides. Increased production of…”
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Zinc α2‐glycoprotein as a potential novel urine biomarker for the early diagnosis of prostate cancer by Katafigiotis, Ioannis, Tyritzis, Stavros I., Stravodimos, Konstantinos G., Alamanis, Christos, Pavlakis, Kitty, Vlahou, Antonia, Makridakis, Manousos, Katafigioti, Amalia, Garbis, Spiros D., Constantinides, Constantinos A.

“…Study Type – Diagnosis (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The use of biomarkers to detect a…”
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MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets by Kotsinas, Athanassios, Sigala, Fragkiska, Garbis, Spiros D, Galyfos, Giorgos, Filis, Konstantinos, Vougas, Konstantinos, Papalampros, Alexandros, Johnson, Elizabeth E, Chronopoulos, Efstathios, Georgakilas, Alexandros G, Gorgoulis, Vassilis G

“…Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the…”
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BDNF-Induced Changes in the Expression of the Translation Machinery in Hippocampal Neurons: Protein Levels and Dendritic mRNA by Manadas, Bruno, Santos, Ana Rita, Szabadfi, Krisztina, Gomes, João R, Garbis, Spiros D, Fountoulakis, Michael, Duarte, Carlos B

“…BDNF plays a key role in neuronal development, in short- and long-term changes in synaptic activity, and in neuronal survival. These effects are mediated, to a…”
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