Search Results - "Garbesi, A"
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G-quartet biomolecular nanowires
Published in Applied physics letters (06-05-2002)“…We present a first-principle investigation of quadruple helix nanowires, consisting of stacked planar hydrogen-bonded guanine tetramers. Our results show that…”
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Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides
Published in Nucleic acids research (01-01-2006)“…Human topoisomerase II (topo II) is the cellular target for a number of widely used antitumor agents, such as etoposide (VP16). These agents ‘poison’ the…”
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Self-assembled guanine ribbons as wide-bandgap semiconductors
Published in Physica. E, Low-dimensional systems & nanostructures (01-03-2002)“…We present a first principle study about the stability and the electronic properties of a new biomolecular solid-state material, obtained by the…”
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Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target
Published in Bioorganic & medicinal chemistry (02-05-2005)“…Synthesis and hybridisation properties of daunomycin–oligonucleotide conjugates designed to bind the polypurine tract of HIV. The conjugation enhances the…”
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Relative DNA binding affinity of helix 3 homeodomain analogues, major groove binders, can be rapidly screened by displacement of prebound ethidium bromide. A comparative study
Published in Organic & biomolecular chemistry (01-01-2004)“…The binding affinity for a 12-bp dsDNA of Antennapedia helix 3 analogues, major groove binders, has been measured by displacement of prebound ethidium bromide,…”
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TAR-RNA binding by HIV-1 Tat protein is selectively inhibited by its L-enantiomer
Published in Nucleic acids research (15-06-1998)“…An oligoribonucleotide, corresponding to the Tat-interactive top half of the HIV-1 TAR RNA stem-loop, was synthesized in both the natural D- and the…”
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Effects of the introduction of L-nucleotides into DNA. Solution structure of the heterochiral duplex d(G-C-G-(L)T-G-C-G).d(C-G-C-A-C-G-C) studied by NMR spectroscopy
Published in Biochemistry (Easton) (28-06-1994)“…The effect of the substitution of a L-nucleoside for a D-nucleoside in the duplex d(G-C-G-T-G-C-G).d(C-G-C-A-C-G-C) was studied by UV and NMR spectroscopy…”
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New TFO Conjugates Containing a Carminomycinone-Derived Chromophore
Published in Bioconjugate chemistry (01-07-2001)“…Conjugates obtained by linking the anthracycline intercalating chromophore to triple helix forming oligonucleotides (TFOs) have been used in a physicochemical…”
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5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies
Published in Molecular pharmacology (01-06-1995)“…5-Iodo-2'-deoxy-L-uridine (L-IdU) and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine (L-BVdU) have been prepared and found to inhibit herpes simplex virus type 1…”
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Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural l-β-nucleosides
Published in Biochimie (1995)“…Among enzymes involved in the synthesis of nucleotides and DNA, some exceptions have recently been found to the universal rule that enzymes act only on one…”
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Native oligodeoxynucleotides specifically active against human immunodeficiency virus type 1 in vitro: a G-quartet-driven effect?
Published in Antimicrobial Agents and Chemotherapy (01-09-1996)“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Lack of stereospecificity of suid pseudorabies virus thymidine kinase
Published in Biochemical journal (01-09-1993)“…We have partially purified suid pseudorabies virus (PRV) thymidine kinase from infected thymidine kinase- mouse cells, and cytosolic swine thymidine kinase…”
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Terminally L-modified oligonucleotides: pairing, stability and biological properties
Published in Anti-cancer drugs (01-02-1996)“…An oligodeoxynucleotide (ODN), capable of reducing the growth of human B lymphocytes carrying the t(14;18) chromosome translocation, was prepared in different…”
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L-DNAs as potential antimessenger oligonucleotides: a reassessment
Published in Nucleic acids research (11-11-1993)“…Nucleic Acids Research, 21, pp. 4159–4165 (1993) The authors wish to apologize for typing mistakes which appeared in figures 3 and 4 of this paper. The correct…”
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31P NMR study of daunorubicin-d(CGTACG) complex in solution Evidence of the intercalation sites
Published in FEBS letters (15-08-1988)“…The interaction of daunorubicin with the self-complementary DNA fragment d(CGTACG) was studied by 31P NMR spectroscopy. The individual phosphates have been…”
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Strain-Dependence of the Electronic Properties in Periodic Quadruple Helical G4-Wires
Published in The journal of physical chemistry. B (01-12-2005)“…The electronic structure of periodic quadruple helix guanine wires, which mimic G4-DNA molecules, was studied as a function of the stacking distance between…”
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Electron Channels in Biomolecular Nanowires
Published in The journal of physical chemistry. B (26-02-2004)“…We report a first-principle study of the electronic and conduction properties of a quadruple-helix guanine wire (G4 wire), a DNA derivative, with inner…”
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Control of the expression of an early gene of SV40 with natural and modified oligonucleotides
Published in Nucleic acids symposium series (1979) (1991)Get more information
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Kinetic acidity of diastereotopic protons in sulfonium ions. A transition state conformational effect
Published in Journal of the American Chemical Society (01-01-1978)Get full text
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