Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T)] is a well-recognized genetic risk factor for venous thrombosis; however, its association with arterial thrombosis is still under debate. Herein, we evaluated the prevalence of MTHFR C677T polymorphism in Georgian patients in comp...

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Published in:Clinical and applied thrombosis/hemostasis Vol. 24; no. 7; pp. 1061 - 1066
Main Authors: Garakanidze, Sopio, Costa, Elísio, Bronze-Rocha, Elsa, Santos-Silva, Alice, Nikolaishvili, Giorgi, Nakashidze, Irina, Kakauridze, Nona, Glonti, Salome, Khukhunaishvili, Rusudan, Koridze, Marina, Ahmad, Sarfraz
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-10-2018
SAGE PUBLICATIONS, INC
Subjects:
Female
Genetic Predisposition to Disease
Georgia (Republic)
Health risk assessment
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Methylenetetrahydrofolate Reductase (NADPH2) - metabolism
Middle Aged
Original
Patients
Plasma
Polymorphism
Polymorphism, Genetic
Risk Factors
Thrombosis
Thrombosis - enzymology
Thrombosis - genetics
methylenetetrahydrofolate reductase
Georgian population
myocardial infarction
C677T
gene polymorphism
arterial thrombosis
risk factor
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Summary:Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T)] is a well-recognized genetic risk factor for venous thrombosis; however, its association with arterial thrombosis is still under debate. Herein, we evaluated the prevalence of MTHFR C677T polymorphism in Georgian patients in comparison with healthy individuals and its association with arterial thrombosis. We enrolled 214 participants: 101 with arterial thrombosis (71.3% males; mean age: 66.3 ± 12.1 years) and 113 controls (67.3% males; mean age: 56.6 ± 11.3 years). Genomic DNA was extracted from dry blood spot on Whatman filter paper. Polymerase chain reaction was performed to determine MTHFR C677T polymorphism. Frequency of C677T allele polymorphism in controls was 21.2%, which corresponded to heterozygous and homozygous stage frequencies of 35.4% and 3.5%, respectively. In patient group, an allelic frequency of 33.2% was found, which corresponded to the presence of 48.5% of heterozygous and 8.9% of homozygous individuals. Comparing the frequency of mutated alleles between the 2 groups, a significantly high frequency of mutated alleles was found in patient group (P < .05). In conclusion, high frequency of MTHFR C677T polymorphism found in arterial thrombosis patient group suggests that this polymorphism might increase the risk of arterial thrombosis in Georgian patients.
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ISSN:1076-0296
1938-2723
DOI:10.1177/1076029618757345