Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic...

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Bibliographic Details
Published in:	Applied radiation and isotopes Vol. 88; pp. 94 - 98
Main Authors:	Trivillin, V.A., Garabalino, M.A., Colombo, L.L., González, S.J., Farías, R.O., Monti Hughes, A., Pozzi, E.C.C., Bortolussi, S., Altieri, S., Itoiz, M.E., Aromando, R.F., Nigg, D.W., Schwint, A.E.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2014 Elsevier
Subjects:	Animals BNCT Boron biodistribution studies Boron Compounds - administration & dosage Boron Compounds - pharmacokinetics Boron Neutron Capture Therapy Boron Neutron Capture Therapy - methods BPA Cell Line, Tumor Drug Combinations GB-10 GENERAL AND MISCELLANEOUS Lung metastas Lung metastases Lung Neoplasms - metabolism Lung Neoplasms - radiotherapy Lung Neoplasms - secondary Metabolic Clearance Rate Organ Specificity Phenylalanine - administration & dosage Phenylalanine - analogs & derivatives Phenylalanine - pharmacokinetics Radiotherapy Dosage Rats Tissue Distribution Lung metastases BNCT BPA Boron biodistribution studies Boron Neutron Capture Therapy GB-10
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Summary:	BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung. •We performed experimental boron biodistribution studies for lung metastases.•3 protocols employing BPA and GB-10 would be therapeutically useful.•BNCT at RA-3 would be potentially therapeutic for experimental lung metastases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 INL/JOU-14-33083 USDOE DE-AC07-05ID14517
ISSN:	0969-8043 1872-9800
DOI:	10.1016/j.apradiso.2013.11.115