Search Results - "Gao, Ziwen"
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AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
Published in The Lancet (British edition) (25-05-2024)“…Autosomal recessive deafness 9, caused by mutations of the OTOF gene, is characterised by congenital or prelingual, severe-to-complete, bilateral hearing loss…”
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Nano-bulk aluminum fabrication from nano powder mixed with micro powder by explosive consolidation
Published in Materials & design (01-07-2022)“…[Display omitted] •Fabricate high mechanical nano-bulk aluminum materials by explosive consolidation.•The products after explosive consolidation are pure…”
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Short Text Aspect-Based Sentiment Analysis Based on CNN + BiGRU
Published in Applied sciences (01-03-2022)“…This paper describes the construction a short-text aspect-based sentiment analysis method based on Convolutional Neural Network (CNN) and Bidirectional Gating…”
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Overexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
Published in Clinical Medicine Insights. Oncology (2022)“…Background: LIMA1 encodes LIM domain and actin binding 1, a cytoskeleton-associated protein whose loss has been linked to migration and invasion behavior of…”
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“Of mice and men”: the relevance of Cometin and Erythropoietin origin for its effects on murine spiral ganglion neuron survival and neurite outgrowth in vitro
Published in Frontiers in neuroscience (10-08-2023)“…Neurotrophic factors (NTF) play key roles in the survival of neurons, making them promising candidates for therapy of neurodegenerative diseases. In the case…”
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Effects of Pine Wilt Disease on Rhizosphere Microbiota and Fine Root Fungi: Insights into Enzyme Activity, Ectomycorrhizal Infection and Microbial Composition
Published in Forests (01-09-2023)“…Pine wilt disease (PWD), caused by the pine wood nematode (PWN) Bursaphelenchus xylophilus, poses a severe threat to pine forests worldwide. However, the…”
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Dexamethasone for Inner Ear Therapy: Biocompatibility and Bio-Efficacy of Different Dexamethasone Formulations In Vitro
Published in Biomolecules (Basel, Switzerland) (17-12-2021)“…Dexamethasone is widely used in preclinical studies and clinical trials to treat inner ear disorders. The results of those studies vary widely, maybe due to…”
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An adaptive simple model trust region algorithm based on new weak secant equations
Published in AIMS mathematics (01-01-2024)“…In this work, we proposed a new trust region method for solving large-scale unconstrained optimization problems. The trust region subproblem with a simple form…”
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Development of a drug delivering round window niche implant for cochlear pharmacotherapy
Published in Drug delivery (01-12-2024)“…There exists an unfulfilled requirement for effective cochlear pharmacotherapy. Controlled local drug delivery could lead to effective bioavailability. The…”
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Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model
Published in Pharmaceutics (23-09-2024)“…Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to…”
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The contribution of the left precuneus to emotion memory in migraine without aura patients
Published in Frontiers in neuroscience (18-10-2022)“…Background The impact of migraine without aura (MWoA) on cognitive function remains controversial, especially given the sparse literature on emotional memory…”
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Molecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress
Published in Parasites & vectors (12-05-2024)“…Epigenetic modifications of histones play important roles in the response of eukaryotic organisms to environmental stress. However, many histone…”
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The protective impact of education on brain structure and function in Alzheimer’s disease
Published in BMC neurology (30-10-2021)“…Abstract Background The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical…”
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Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity
Published in Frontiers in cell and developmental biology (08-01-2024)“…Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections, however, aminoglycosides may cause irreversible hearing loss with…”
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Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer
Published in Frontiers in aging neuroscience (03-06-2021)“…Background : Alzheimer’s disease (AD) manifests differently in males and females. However, the neuro-mechanism and influence factors are still unknown…”
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The Influence of Shape Parameters on Unidirectional Drug Release from 3D Printed Implants and Prediction of Release from Implants with Individualized Shapes
Published in Pharmaceutics (01-04-2023)“…The local treatment of diseases by drug-eluting implants is a promising tool to enable successful therapy under potentially reduced systemic side effects…”
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High Variability of Postsurgical Anatomy Supports the Need for Individualized Drug-Eluting Implants to Treat Chronic Rhinosinusitis
Published in Life (Basel, Switzerland) (17-12-2020)“…Chronic rhinosinusitis (CRS) is a common disease in the general population that is increasing in incidence and prevalence, severely affecting patients' quality…”
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Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates
Published in Molecular therapy. Methods & clinical development (14-12-2023)“…Pathogenic mutations in the OTOF gene cause autosomal recessive hearing loss (DFNB9), one of the most common forms of auditory neuropathy. There is no…”
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Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds
Published in Pharmaceutics (24-05-2023)“…A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a…”
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