Search Results - "Gao, Zhaobing"

MLKL forms cation channels by Xia, Bingqing, Fang, Sui, Chen, Xueqin, Hu, Hong, Chen, Peiyuan, Wang, Huayi, Gao, Zhaobing

“…The mixed lineage kinase domain-like （MLKL） protein is a key factor in tumor necrosis factor-induced necropto- sis. Recent studies on necroptosis execution…”
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The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations by Cao, Birong, Wang, Xiaoxi, Yin, Wanchao, Gao, Zhaobing, Xia, Bingqing

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are rapidly emerging. In particular, beneficial mutations in the spike (S) protein,…”
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target by Xia, Bingqing, Shen, Xurui, He, Yang, Pan, Xiaoyan, Liu, Feng-Liang, Wang, Yi, Yang, Feipu, Fang, Sui, Wu, Yan, Duan, Zilei, Zuo, Xiaoli, Xie, Zhuqing, Jiang, Xiangrui, Xu, Ling, Chi, Hao, Li, Shuangqu, Meng, Qian, Zhou, Hu, Zhou, Yubo, Cheng, Xi, Xin, Xiaoming, Jin, Lin, Zhang, Hai-Lin, Yu, Dan-Dan, Li, Ming-Hua, Feng, Xiao-Li, Chen, Jiekai, Jiang, Hualiang, Xiao, Gengfu, Zheng, Yong-Tang, Zhang, Lei-Ke, Shen, Jingshan, Li, Jia, Gao, Zhaobing

“…Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death. However, the origin of excessive damages caused by SARS-CoV-2 remains…”
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Dynamic PIP₂ interactions with voltage sensor elements contribute to KCNQ2 channel gating by Zhang, Qiansen, Zhou, Pingzheng, Chen, Zhuxi, Li, Min, Jiang, Hualiang, Gao, Zhaobing, Yang, Huaiyu

“…The S4 segment and the S4–S5 linker of voltage-gated potassium (Kv) channels are crucial for voltage sensing. Previous studies on the Shaker and Kv1.2 channels…”
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Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation by Tian, Fuyun, Cao, Birong, Xu, Haiyan, Zhan, Li, Nan, Fajun, Li, Ning, Taglialatela, Maurizio, Gao, Zhaobing

“…KCNQ2-encoded Kv7.2 subunits play a critical role in balancing neuronal excitability. Mutations in KCNQ2 are responsible for highly-heterogenous epileptic and…”
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Ligand activation mechanisms of human KCNQ2 channel by Ma, Demin, Zheng, Yueming, Li, Xiaoxiao, Zhou, Xiaoyu, Yang, Zhenni, Zhang, Yan, Wang, Long, Zhang, Wenbo, Fang, Jiajia, Zhao, Guohua, Hou, Panpan, Nan, Fajun, Yang, Wei, Su, Nannan, Gao, Zhaobing, Guo, Jiangtao

“…The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be activated…”
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An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG by Liu, Zhipei, Wang, Feng, Yuan, Hui, Tian, Fuyun, Yang, Chuanyan, Hu, Fei, Liu, Yiyao, Tang, Meiqin, Ping, Meixuan, Kang, Chunlan, Luo, Ting, Yang, Guimei, Hu, Mei, Gao, Zhaobing, Li, Ping

“…Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For…”
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High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice by Yin, Xianzhen, Zhang, Xiaochuan, Zhang, Jingjing, Yang, Weicheng, Sun, Xian, Zhang, Haiyan, Gao, Zhaobing, Jiang, Hualiang

“…Simultaneously visualizing Amyloid-β (Aβ) plaque with its surrounding brain structures at the subcellular level in the intact brain is essential for…”
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Enhanced channel activity by PI(4,5)P2 ignites MLKL-related pathogenic processes by Xia, Bingqing, Qie, Jingbo, Shen, Xurui, Wang, Sheng, Gao, Zhaobing

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An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy by Wang, Cong, Sun, Wanbing, Zhang, Jun, Zhang, Jianping, Guo, Qinghua, Zhou, Xingyu, Fan, Dandan, Liu, Haoran, Qi, Ming, Gao, Xihui, Xu, Haiyan, Gao, Zhaobing, Tian, Mei, Zhang, Hong, Wang, Jianhong, Wei, Zixuan, Long, Nicholas J., Mao, Ying, Li, Cong

“…For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective treatment approach. However, the surgery is less…”
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Computer-Aided Drug Discovery and Design Targeting Ion Channels by Zhang, Qiansen, Gao, Zhaobing, Yang, Huaiyu

“…Ion channels are widely expressed in living cells and play critical roles in various cellular biological functions. Dysfunctional ion channels can cause a…”
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The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands by Li, Ping, Chen, Zhuxi, Xu, Haiyan, Sun, Haifeng, Li, Hao, Liu, Hong, Yang, Huaiyu, Gao, Zhaobing, Jiang, Hualiang, Li, Min

“…Voltage-gated potassium （Kv） channels derive their voltage sensitivity from movement of gating charges in volt- age-sensor domains （VSDs）. The gating charges…”
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Activation of GABA type A receptor is involved in the anti-insomnia effect of Huanglian Wendan Decoction by Li, Liang, Wu, Xiaorong, Gong, Jili, Wang, Zhuqiang, Dai, Weibo, Qiu, Li, Zuo, Hongyuan, Yi, Mengqin, Yuan, Hui, Hu, Mei, Gao, Zhaobing, Tian, Fuyun

“…Huanglian Wendan Decoction (HWD) is a traditional Chinese medicine (TCM) prescribed to patients diagnosed with insomnia, which can achieve excellent…”
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Why is the SARS-CoV-2 Omicron variant milder? by Xia, Bingqing, Wang, Yi, Pan, Xiaoyan, Cheng, Xi, Ji, Hongying, Zuo, Xiaoli, Jiang, Hualiang, Li, Jia, Gao, Zhaobing

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Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors by Zeng, Yue, Zheng, Yueming, Zhang, Tongtong, Ye, Fei, Zhan, Li, Kou, Zengwei, Zhu, Shujia, Gao, Zhaobing

“…N-methyl-D-aspartate receptors (NMDARs) are Ca 2+ -permeable ionotropic glutamate receptors (iGluRs) in the central nervous system and play important roles in…”
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Study on structure-activity relationship (SAR) of simplified mirogabalin derivatives as voltage-gated calcium channel α2δ ligands for the treatment of chronic neuropathic pain by Zhang, Yuanwen, Zheng, Yueming, Wu, Qingqing, Tian, Fuyun, Ma, Chuanjun, Xu, Haiyan, Zhan, Li, Gao, Zhaobing, Zhao, Guilong, Ti, Huihui

“…A clinical therapy for chronic neuropathic pain is urgently needed, and the voltage-gated calcium channel (VGCC) α2δ subunit is among the most promising…”
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Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2 by Xia, Bingqing, Pan, Xiaoyan, Luo, Rong-Hua, Shen, Xurui, Li, Shuangqu, Wang, Yi, Zuo, Xiaoli, Wu, Yan, Guo, Yingqi, Xiao, Gengfu, Li, Qiguang, Long, Xin-Yan, He, Xiao-Yan, Zheng, Hong-Yi, Lu, Ying, Pang, Wei, Zheng, Yong-Tang, Li, Jia, Zhang, Lei-Ke, Gao, Zhaobing

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Antibody resistance dampens neutralizing antibody therapy and…”
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Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels by Zhou, Pingzheng, Yu, Haibo, Gu, Min, Nan, Fa-jun, Gao, Zhaobing, Li, Min

“…Pharmacological augmentation of neuronal KCNQ muscarinic (M) currents by drugs such as retigabine (RTG) represents a first-in-class therapeutic to treat…”
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Grafting voltage and pharmacological sensitivity in potassium channels by Lan, Xi, Fan, Chunyan, Ji, Wei, Tian, Fuyun, Xu, Tao, Gao, Zhaobing

“…A classical voltage-gated ion channel consists of four voltage-sensing domains （VSDs）. However, the roles of each VSD in the channels remain elusive. We…”
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Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants by Zheng, Yueming, Zhu, Xuejing, Zhou, Pingzheng, Lan, Xi, Xu, Haiyan, Li, Min, Gao, Zhaobing

“…The voltage-gated KCNQ1 potassium channel is expressed in cardiac tissues, and coassembly of KCNQ1 with an auxiliary KCNE1 subunit mediates a slowly activating…”
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