Search Results - "Gao, Xinliu"

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  1. 1

    Targeted Host Cell Protein Quantification by LC–MRM Enables Biologics Processing and Product Characterization by Gao, Xinliu, Rawal, Baibhav, Wang, Yi, Li, Xuanwen, Wylie, David, Liu, Yan-Hui, Breunig, Lloyd, Driscoll, Dennis, Wang, Fengqiang, Richardson, Douglas D

    Published in Analytical chemistry (Washington) (07-01-2020)
    “…Multiple reaction monitoring (MRM) is a liquid chromatography–mass spectrometry (LC–MS) based quantification platform with high sensitivity, specificity, and…”
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    Journal Article
  2. 2

    Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS by Whitty-Léveillé, Laurence, VanAernum, Zachary L, Pavon, Jorge Alexander, Murphy, Christa, Neal, Katie, Forest, William, Gao, Xinliu, Zhong, Wendy, Richardson, Douglas D, Schuessler, Hillary A

    Published in mAbs (2023)
    “…Transition metals can be introduced in therapeutic protein drugs at various steps of the manufacturing process (e.g. manufacturing raw materials, formulation,…”
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    Journal Article
  3. 3

    Enzymatic activity of the alternative complex III as a menaquinol:auracyanin oxidoreductase in the electron transfer chain of Chloroflexus aurantiacus by Gao, Xinliu, Xin, Yueyong, Blankenship, Robert E.

    Published in FEBS letters (06-10-2009)
    “…The surprising lack of the cytochrome bc 1 complex in the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus suggests that a functional…”
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    Journal Article
  4. 4

    Structural Analysis of Alternative Complex III in the Photosynthetic Electron Transfer Chain of Chloroflexus aurantiacus by Gao, Xinliu, Xin, Yueyong, Bell, Patrick D, Wen, Jianzhong, Blankenship, Robert E

    Published in Biochemistry (Easton) (10-08-2010)
    “…The green photosynthetic bacterium Chloroflexus aurantiacus, which belongs to the phylum of filamentous anoxygenic phototrophs, does not contain a cytochrome…”
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    Journal Article
  5. 5

    Extended characterization of unpaired cysteines in an IgG1 monoclonal antibody by LC-MS analysis by Li, Xiaojuan, Xiao, Li, Kochert, Brent, Donnelly, Daniel P., Gao, Xinliu, Richardson, Douglas

    Published in Analytical biochemistry (01-06-2021)
    “…The development of comprehensive methods to characterize unpaired cysteines in monoclonal antibodies (mAbs) is very important for understanding structural…”
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    Journal Article
  6. 6

    Precise O‑Glycosylation Site Localization of CD24Fc by LC-MS Workflows by Li, Xiaojuan, Wilmanowski, Robert, Gao, Xinliu, VanAernum, Zachary L., Donnelly, Daniel P., Kochert, Brent, Schuessler, Hillary A., Richardson, Douglas

    Published in Analytical chemistry (Washington) (14-06-2022)
    “…CD24Fc is a homodimeric recombinant Fc-fusion protein comprised of human CD24 connected to immunoglobulin G1 (IgG1) Fc fragment. CD24 is heavily glycosylated,…”
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    Journal Article
  7. 7

    LC–MS Approach to Decipher a Light Chain Chromatographic Peak Splitting of a Monoclonal Antibody by Liu, Yanjun, VanAernum, Zac, Zhang, Yue, Gao, Xinliu, Vlad, Mariana, Feng, Bo, Cross, Robert, Kilgore, Bruce, Newman, Alice, Wang, Dongdong, Schuessler, Hillary A., Richardson, Douglas D., Chadwick, Jennifer S.

    Published in Pharmaceutical research (01-12-2023)
    “…Purpose Monoclonal antibodies (mAbs), like other protein therapeutics, are prone to various forms of degradation, some of which are difficult to distinguish…”
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    Journal Article
  8. 8

    Temporal Changes in Milk Proteomes Reveal Developing Milk Functions by Gao, Xinliu, McMahon, Robert J, Woo, Jessica G, Davidson, Barbara S, Morrow, Ardythe L, Zhang, Qiang

    Published in Journal of proteome research (06-07-2012)
    “…Human milk proteins provide essential nutrition for growth and development, and support a number of vital developmental processes in the neonate. A complete…”
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    Journal Article
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  12. 12

    Functional analysis and expression of the mono-heme containing cytochrome c subunit of alternative complex III in Chloroflexus aurantiacus by Gao, Xinliu, Majumder, Erica Wunderlich, Kang, Yisheng, Yue, Hai, Blankenship, Robert E.

    Published in Archives of biochemistry and biophysics (15-07-2013)
    “…•ActE subunit of Alternative Complex III (ACIII) cloned and expressed.•ACIII treated with chaotropic agents to remove ActE.•ActE reconstituted to depleted…”
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    Journal Article
  13. 13

    Expression and characterization of the diheme cytochrome c subunit of the cytochrome bc complex in Heliobacterium modesticaldum by Yue, Hai, Kang, Yisheng, Zhang, Hao, Gao, Xinliu, Blankenship, Robert E.

    Published in Archives of biochemistry and biophysics (15-01-2012)
    “…► Diheme cytochrome c from heliobacterial cytochrome bc complex is expressed in Escherichia coli and purified. ► Mass spectra confirm the correct expression of…”
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    Journal Article
  14. 14

    Semi‐quantitative analysis of milk proteomes reveals new evolving activities in carbohydrate metabolism in breastfeeding women by Gao, Xinliu, Zhang, Qiang, McMahon, Robert J, Woo, Jessica G, Davidson, Barbara S, Morrow, Ardythe L

    Published in The FASEB journal (01-04-2012)
    “…Abstract only Human milk proteins are thought to support a number of fundamental biological processes in the neonate. Among these processes may be carbohydrate…”
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    Journal Article
  15. 15

    Proteomics reveals new evolving roles in defense and development from colostrum to mature milk by Zhang, Qiang, Gao, Xinliu, McMahon, Robert J, Woo, Jessica G, Davidson, Barbara S, Morrow, Ardythe L

    Published in The FASEB journal (01-04-2012)
    “…Abstract only Human milk proteins provide nutrition and support a number of vital biological processes in nursing infants. In‐depth understanding of the…”
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    Journal Article
  16. 16

    Quantitative analysis of factor P (Properdin) in monkey serum using immunoaffinity capturing in combination with LC-MS/MS by Gao, Xinliu, Lin, Hui, Krantz, Carsten, Garnier, Arlette, Flarakos, Jimmy, Tse, Francis L S, Li, Wenkui

    Published in Bioanalysis (01-01-2016)
    “…Factor P (Properdin), an endogenous glycoprotein, plays a key role in innate immune defense. Its quantification is important for understanding the…”
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    Journal Article
  17. 17

    Structural and functional study of Alternative Complex III in the photosynthetic electron transfer chain of Chloroflexus aurantiacus by Gao, Xinliu

    Published 01-01-2011
    “…This dissertation focuses on the structural and functional study of a newly found electron transfer protein complex in Chloroflexus aurantiacus. The lack of…”
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    Dissertation
  18. 18

    Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules by Gao, Xinliu, Wang, Xiaoyong, Ding, Jian, Lin, Liping, Li, Yizhi, Guo, Zijian

    Published in Inorganic chemistry communications (01-07-2006)
    “…The platinum(II) complexes of l-valine- N-8-quinolylamide and l-leucine- N-8-quinolylamide were shown to bind to DNA with high affinity and demonstrated…”
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    Journal Article
  19. 19

    Structural and functional study of Alternative Complex III in the photosynthetic electron transfer chain of Chloroflexus aurantiacus by Gao, Xinliu

    “…This dissertation focuses on the structural and functional study of a newly found electron transfer protein complex in Chloroflexus aurantiacus. The lack of…”
    Get full text
    Dissertation
  20. 20

    Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS by Whitty-Léveillé, Laurence, VanAernum, Zachary L., Pavon, Jorge Alexander, Murphy, Christa, Neal, Katie, Forest, William, Gao, Xinliu, Zhong, Wendy, Richardson, Douglas D., Schuessler, Hillary A.

    Published in mAbs (31-12-2023)
    “…Transition metals can be introduced in therapeutic protein drugs at various steps of the manufacturing process (e.g. manufacturing raw materials, formulation,…”
    Get full text
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