Search Results - "Gao, Xing‐Huang"

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway by Ziosi, Marcello, Di Meo, Ivano, Kleiner, Giulio, Gao, Xing‐Huang, Barca, Emanuele, Sanchez‐Quintero, Maria J, Tadesse, Saba, Jiang, Hongfeng, Qiao, Changhong, Rodenburg, Richard J, Scalais, Emmanuel, Schuelke, Markus, Willard, Belinda, Hatzoglou, Maria, Tiranti, Valeria, Quinzii, Catarina M

“…Coenzyme Q (CoQ) is an electron acceptor for sulfide‐quinone reductase (SQR), the first enzyme of the hydrogen sulfide oxidation pathway. Here, we show that…”
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Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism by Gao, Xing-Huang, Li, Ling, Parisien, Marc, Wu, Jing, Bederman, Ilya, Gao, Zhaofeng, Krokowski, Dawid, Chirieleison, Steven M., Abbott, Derek, Wang, Benlian, Arvan, Peter, Cameron, Mark, Chance, Mark, Willard, Belinda, Hatzoglou, Maria

“…A mechanism for the cellular effects of the gas H2S, is the oxidative modification of protein cysteine residues. We developed a quantitative proteomics tool to…”
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Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response by Gao, Xing-Huang, Krokowski, Dawid, Guan, Bo-Jhih, Bederman, Ilya, Majumder, Mithu, Parisien, Marc, Diatchenko, Luda, Kabil, Omer, Willard, Belinda, Banerjee, Ruma, Wang, Benlian, Bebek, Gurkan, Evans, Charles R, Fox, Paul L, Gerson, Stanton L, Hoppel, Charles L, Liu, Ming, Arvan, Peter, Hatzoglou, Maria

“…The sulfhydration of cysteine residues in proteins is an important mechanism involved in diverse biological processes. We have developed a proteomics approach…”
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PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation by Farabaugh, Kenneth T, Krokowski, Dawid, Guan, Bo-Jhih, Gao, Zhaofeng, Gao, Xing-Huang, Wu, Jing, Jobava, Raul, Ray, Greeshma, de Jesus, Tristan J, Bianchi, Massimiliano G, Chukwurah, Evelyn, Bussolati, Ovidio, Kilberg, Michael, Buchner, David A, Sen, Ganes C, Cotton, Calvin, McDonald, Christine, Longworth, Michelle, Ramakrishnan, Parameswaran, Hatzoglou, Maria

“…The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription…”
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A transcriptional evaluation of the melanoma and squamous cell carcinoma TIL compartment reveals an unexpected spectrum of exhausted and functional T cells by Cameron, Cheryl M, Richardson, Brian, Golden, Jackelyn B, Phoon, Yee Peng, Tamilselvan, Banumathi, Pfannenstiel, Lukas, Thapaliya, Samjhana, Roversi, Gustavo, Gao, Xing-Huang, Zagore, Leah L, Cameron, Mark J, Gastman, Brian R

“…Significant heterogeneity exists within the tumor-infiltrating CD8 T cell population, and exhausted T cells harbor a subpopulation that may be replicating and…”
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GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells by Krokowski, Dawid, Guan, Bo-Jhih, Wu, Jing, Zheng, Yuke, Pattabiraman, Padmanabhan P., Jobava, Raul, Gao, Xing-Huang, Di, Xiao-Jing, Snider, Martin D., Mu, Ting-Wei, Liu, Shijie, Storrie, Brian, Pearlman, Eric, Blumental-Perry, Anna, Hatzoglou, Maria

“…GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function in hyperosmotic stress through its well-known role in the integrated…”
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Atypical Iron-Sulfur Cluster Binding, Redox Activity and Structural Properties of Chlamydomonas reinhardtii Glutaredoxin 2 by Roret, Thomas, Zhang, Bo, Moseler, Anna, Dhalleine, Tiphaine, Gao, Xing-Huang, Couturier, Jérémy, Lemaire, Stéphane D., Didierjean, Claude, Johnson, Michael K., Rouhier, Nicolas

“…Glutaredoxins (GRXs) are thioredoxin superfamily members exhibiting thiol-disulfide oxidoreductase activity and/or iron-sulfur (Fe-S) cluster binding…”
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Regulation by Glutathionylation of Isocitrate Lyase from Chlamydomonas reinhardtii by Bedhomme, Mariette, Zaffagnini, Mirko, Marchand, Christophe H., Gao, Xing-Huang, Moslonka-Lefebvre, Mathieu, Michelet, Laure, Decottignies, Paulette, Lemaire, Stéphane D.

“…Post-translational modification of protein cysteine residues is emerging as an important regulatory and signaling mechanism. We have identified numerous…”
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Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress by Saikia, Mridusmita, Jobava, Raul, Parisien, Marc, Putnam, Andrea, Krokowski, Dawid, Gao, Xing-Huang, Guan, Bo-Jhih, Yuan, Yiyuan, Jankowsky, Eckhard, Feng, Zhaoyang, Hu, Guo-fu, Pusztai-Carey, Marianne, Gorla, Madhavi, Sepuri, Naresh Babu V., Pan, Tao, Hatzoglou, Maria

“…Adaptation to changes in extracellular tonicity is essential for cell survival. However, severe or chronic hyperosmotic stress induces apoptosis, which…”
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DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer by Merry, Callie R, Forrest, Megan E, Sabers, Jessica N, Beard, Lydia, Gao, Xing-Huang, Hatzoglou, Maria, Jackson, Mark W, Wang, Zhenghe, Markowitz, Sanford D, Khalil, Ahmad M

“…The cancer epigenome exhibits global loss of DNA methylation, which contributes to genomic instability and aberrant gene expression by mechanisms that are yet…”
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Aging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulation by Gao, Xing-Huang, Qanungo, Suparna, Pai, Harish V, Starke, David W, Steller, Kelly M, Fujioka, Hisashi, Lesnefsky, Edward J, Kerner, Janos, Rosca, Mariana G, Hoppel, Charles L, Mieyal, John J

“…Clinical and animal studies have documented that hearts of the elderly are more susceptible to ischemia/reperfusion damage compared to young adults. Recently…”
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A Unique ISR Program Determines Cellular Responses to Chronic Stress by Guan, Bo-Jhih, van Hoef, Vincent, Jobava, Raul, Elroy-Stein, Orna, Valasek, Leos S., Cargnello, Marie, Gao, Xing-Huang, Krokowski, Dawid, Merrick, William C., Kimball, Scot R., Komar, Anton A., Koromilas, Antonis E., Wynshaw-Boris, Anthony, Topisirovic, Ivan, Larsson, Ola, Hatzoglou, Maria

“…The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global…”
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Insight into protein S-nitrosylation in Chlamydomonas reinhardtii by Morisse, Samuel, Zaffagnini, Mirko, Gao, Xing-Huang, Lemaire, Stéphane D, Marchand, Christophe H

“…Protein S-nitrosylation, a post-translational modification (PTM) consisting of the covalent binding of nitric oxide (NO) to a cysteine thiol moiety, plays a…”
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Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation by Sabens Liedhegner, Elizabeth A, Gao, Xing-Huang, Mieyal, John J

“…Neurodegenerative diseases are characterized by progressive loss of neurons. A common feature is oxidative stress, which arises when reactive oxygen species…”
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Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase by Kenche, Harshavardhan, Ye, Zhi-Wei, Vedagiri, Kokilavani, Richards, Dylan M., Gao, Xing-Huang, Tew, Kenneth D., Townsend, Danyelle M., Blumental-Perry, Anna

“…Identification of factors contributing to the development of chronic obstructive pulmonary disease (COPD) is crucial for developing new treatments. An increase…”
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Glutaredoxin s12: unique properties for redox signaling by Zaffagnini, Mirko, Bedhomme, Mariette, Marchand, Christophe H, Couturier, J R My, Gao, Xing-Huang, Rouhier, Nicolas, Trost, Paolo, Lemaire, St Phane D

“…Cysteines (Cys) made acidic by the protein environment are generally sensitive to pro-oxidant molecules. Glutathionylation is a post-translational modification…”
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Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress by Farabaugh, Kenneth T., Majumder, Mithu, Guan, Bo-Jhih, Jobava, Raul, Wu, Jing, Krokowski, Dawid, Gao, Xing-Huang, Schuster, Andrew, Longworth, Michelle, Chan, Edward D., Bianchi, Massimiliano, Dey, Madhusudan, Koromilas, Antonis E., Ramakrishnan, Parameswaran, Hatzoglou, Maria

“…High extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the…”
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Methods for Analysis of Protein Glutathionylation and their Application to Photosynthetic Organisms by Gao, Xing-Huang, Bedhomme, Mariette, Veyel, Daniel, Zaffagnini, Mirko, Lemaire, Stéphane D.

“…Protein S-glutathionylation, the reversible formation of a mixed-disulfide between glutathione and protein thiols, is involved in protection of protein…”
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Biochemical characterization of glutaredoxins from Chlamydomonas reinhardtii: Kinetics and specificity in deglutathionylation reactions by Gao, Xing-Huang, Zaffagnini, Mirko, Bedhomme, Mariette, Michelet, Laure, Cassier-Chauvat, Corinne, Decottignies, Paulette, Lemaire, Stéphane D.

“…Protein deglutathionylation is mainly catalyzed by glutaredoxins (GRXs). We have analyzed the biochemical properties of four of the six different GRXs of…”
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Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway by Yadav, Vinita, Gao, Xing-Huang, Willard, Belinda, Hatzoglou, Maria, Banerjee, Ruma, Kabil, Omer

“…Hydrogen sulfide (H2S) regulates various physiological processes, including neuronal activity, vascular tone, inflammation, and energy metabolism. Moreover,…”
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