Search Results - "Gao, Phillip"

On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseases by Naik, Subhashchandra, Zhang, Na, Gao, Phillip, Fisher, Mark T

“…Correcting aberrant folds that develop during protein folding disease states is now an active research endeavor that is attracting increasing attention from…”
Get more information

Review on porous materials for the thermal stabilization of proteins by Montoya, Nicole A., Roth, Rhianna E., Funk, Elizabeth K., Gao, Phillip, Corbin, David R., Shiflett, Mark B.

“…Proteins, the key components of vaccines, enzymes and many types of therapeutics, are sensitive to denaturing and loss of structure when exposed to high…”
Get full text

Protein Stabilization and Delivery: A Case Study of Invasion Plasmid Antigen D Adsorbed on Porous Silica by Montoya, Nicole A, Barr, Kaylee E, Morales, Simon Velasquez, Umana, Jorge E, Ny, Channary, Roth, Rhianna E, Reyes, Edward J, Kirchhoff, Brian C, Hartman, Eric R, Higgins, Lillian L, Nichol, Kalena M, Morais, Ana Rita C, Allgeier, Alan M, Gao, Phillip, Picking, William D, Corbin, David R, Shiflett, Mark B

“…Approximately half of all vaccines produced annually are wasted because effectivity is dependent on protein structure and heat exposure disrupts the…”
Get full text

Monitoring the Kinetics of the pH-Driven Transition of the Anthrax Toxin Prepore to the Pore by Biolayer Interferometry and Surface Plasmon Resonance by Naik, Subhashchandra, Brock, Susan, Akkaladevi, Narahari, Tally, Jon, Mcginn-Straub, Wesley, Zhang, Na, Gao, Phillip, Gogol, E. P, Pentelute, B. L, Collier, R. John, Fisher, Mark T

“…Domain 2 of the anthrax protective antigen (PA) prepore heptamer unfolds and refolds during endosome acidification to generate an extended 100 Å β barrel pore…”
Get full text

Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio‐layer interferometry by Naik, Subhashchandra, Kumru, Ozan S., Cullom, Melissa, Telikepalli, Srivalli N., Lindboe, Elizabeth, Roop, Taylor L., Joshi, Sangeeta B., Amin, Divya, Gao, Phillip, Middaugh, C. Russell, Volkin, David B., Fisher, Mark T.

“…The ability of a GroEL‐based bio‐layer interferometry (BLI) assay to detect structurally altered and/or aggregated species of pharmaceutically relevant…”
Get full text

Probing structurally altered and aggregated states of therapeutically relevant proteins using G roEL coupled to bio‐layer interferometry by Naik, Subhashchandra, Kumru, Ozan S., Cullom, Melissa, Telikepalli, Srivalli N., Lindboe, Elizabeth, Roop, Taylor L., Joshi, Sangeeta B., Amin, Divya, Gao, Phillip, Middaugh, C. Russell, Volkin, David B., Fisher, Mark T.

“…The ability of a GroEL‐based bio‐layer interferometry (BLI) assay to detect structurally altered and/or aggregated species of pharmaceutically relevant…”
Get full text

Development of Silica-Immobilized Vaccines for Improving Thermo-Tolerance and Shelf-Life by Montoya, Nicole, Barr, Kaylee, Kirchhoff, Brian, Reyes, Edward, Umana, Jorge, Nichol, Kalena, Hartman, Eric, Picking, William, Gao, Fei Phillip, Corbin, David R., Shiflett, Mark B.

Get full text

Development of Silica-Immobilized Vaccines for Improving Thermo-Tolerance and Shelf-Life by Montoya, Nicole, Barr, Kaylee, Kirchhoff, Brian, Reyes, Edward, Umana, Jorge, Nichol, Kalena, Hartman, Eric, Picking, William, Gao, Fei Phillip, Corbin, David R, Shiflett, Mark B

“…It is estimated that 50% of vaccines produced annually are wasted because effectivity is dependent on protein structure and heat exposure disrupts the…”
Get full text