Search Results - "Gao, Jian Xin"

Cancer stem cells: the lessons from pre‐cancerous stem cells by Gao, Jian‐Xin

“…•  Introduction •  Stem cells and cancer stem cells ‐  Properties of stem cells ‐  Cancer stem cell hypothesis •  Development of pre‐cancerous and cancer stem…”
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A requirement of dendritic cell‐derived interleukin‐27 for the tumor infiltration of regulatory T cells by Xia, Siyuan, Wei, Jun, Wang, Jingya, Sun, Huayan, Zheng, Wenting, Li, Yangguang, Sun, Yanbo, Zhao, Huiyuan, Zhang, Song, Wen, Ti, Zhou, Xinglong, Gao, Jian‐Xin, Wang, Puyue, Wu, Zhenzhou, Zhao, Liqing, Yin, Zhinan

“…IL‐27 promotes immunosuppressive Treg recruitment into tumors, by inducing dendritic cell derived CCL22 production. Tregs (Foxp3+CD4+) are enriched in tumors…”
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Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells by Wei, Jun, Xia, Siyuan, Sun, Huayan, Zhang, Song, Wang, Jingya, Zhao, Huiyuan, Wu, Xiaoli, Chen, Xi, Hao, Jianlei, Zhou, Xinglong, Zhu, Zhengmao, Gao, Xiang, Gao, Jian-xin, Wang, Puyue, Wu, Zhenzhou, Zhao, Liqing, Yin, Zhinan

“…Critical roles of IL-27 in autoimmune diseases and infections have been reported; however, the contribution of endogenous IL-27 to tumor progression remains…”
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Precancerous stem cells can serve as tumor vasculogenic progenitors by Shen, Rulong, Ye, Yin, Chen, Li, Yan, Qingtao, Barsky, Sanford H, Gao, Jian-Xin

“…Tumor neo-vascularization is critical for tumor growth, invasion and metastasis, which has been considered to be mediated by a mechanism of angiogenesis…”
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A Negative Regulator of Cellulose Biosynthesis, bcsR , Affects Biofilm Formation, and Adhesion/Invasion Ability of Cronobacter sakazakii by Gao, Jian-Xin, Li, Ping, Du, Xin-Jun, Han, Zhong-Hui, Xue, Rui, Liang, Bin, Wang, Shuo

“…is an important foodborne pathogen that causes neonatal meningitis and sepsis, with high mortality in neonates. However, very little information is available…”
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MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA by Li, Chao, Zhu, Hua-Yu, Bai, Wen-Dong, Su, Lin-Lin, Liu, Jia-Qi, Cai, Wei-Xia, Zhao, Bin, Gao, Jian-Xin, Han, Shi-Chao, Li, Jun, Hu, Da-Hai

“…•uPA and PAI-1 are aberrantly expressed in hypertrophic scars (HS).•uPA is targeted by miR-181c in hypertrophic scar fibroblasts (HFs).•PAI-1 is targeted by…”
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Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis by Ye, Yin, Yin, De-Tao, Chen, Li, Zhou, Quansheng, Shen, Rulong, He, Gang, Yan, Qingtao, Tong, Zhenyu, Issekutz, Andrew C, Shapiro, Charles L, Barsky, Sanford H, Lin, Haifan, Li, Jian-Jian, Gao, Jian-Xin

“…PIWIL2, a member of PIWI/AGO gene family, is expressed in the germline stem cells (GSCs) of testis for gametogenesis but not in adult somatic and stem cells…”
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Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin by Yin, De-Tao, Wang, Qien, Chen, Li, Liu, Meng-Yao, Han, Chunhua, Yan, Qingtao, Shen, Rulong, He, Gang, Duan, Wenrui, Li, Jian-Jian, Wani, Altaf, Gao, Jian-Xin

“…DNA damage response (DDR) is an intrinsic barrier of cell to tumorigenesis initiated by genotoxic agents. However, the mechanisms underlying the DDR are not…”
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Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways by Pan, Qi, Yang, Guo-Liang, Yang, Jiang-Hua, Lin, Shi-Long, Liu, Ning, Liu, Shan-Shan, Liu, Meng-Yao, Zhang, Lian-Hua, Huang, Yi-Ran, Shen, Ru-long, Liu, Qiang, Gao, Jian-Xin, Bo, Juan-Jie

“…Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a…”
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Precancerous stem cells have the potential for both benign and malignant differentiation by Chen, Li, Shen, Rulong, Ye, Yin, Pu, Xin-An, Liu, Xingluo, Duan, Wenrui, Wen, Jing, Zimmerer, Jason, Wang, Ying, Liu, Yan, Lasky, Larry C, Heerema, Nyla A, Perrotti, Danilo, Ozato, Keiko, Kuramochi-Miyagawa, Satomi, Nakano, Toru, Yates, Allen J, Carson, 3rd, William E, Lin, Haifan, Barsky, Sanford H, Gao, Jian-Xin

“…Cancer stem cells (CSCs) have been identified in hematopoietic and solid tumors. However, their precursors-namely, precancerous stem cells (pCSCs) -have not…”
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B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism by Liu, Xingluo, Gao, Jian Xin, Wen, Jing, Yin, Lijie, Li, Ou, Zuo, Tao, Gajewski, Thomas F, Fu, Yang-Xin, Zheng, Pan, Liu, Yang

“…B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies…”
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Antitumor Activity of G3139 Lipid Nanoparticles (LNPs) by Pan, Xiaogang, Chen, Li, Liu, Shujun, Yang, Xiaojuan, Gao, Jian-Xin, Lee, Robert J

“…G3139, an antisense oligodeoxyribonucleotide (ODN) against Bcl-2, contains two CpG dinucleotides and has shown immunostimulatory activities in preclinical…”
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Natural killer dendritic cells are an intermediate of developing dendritic cells by Chen, Li, Calomeni, Edward, Wen, Jing, Ozato, Keiko, Shen, Rulong, Gao, Jian‐Xin

“…NK dendritic cells (DCs; NKDCs) appear to emerge as a distinct DC subset in humans and rodents, which have the functions of NK cells and DCs. However, the…”
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Inhibiting the CD8+ T cell infiltration in the tumor microenvironment after radiotherapy is an important mechanism of radioresistance by Chen, Hai-yan, Xu, Lei, Li, Lin-feng, Liu, Xiao-xing, Gao, Jian-xin, Bai, Yong-rui

“…Endogenous immune response participates in tumor control, and radiotherapy has immune modulatory capacity, but the role of immune modulation in the tumor…”
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Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis by Ma, Xue-Lian, Li, Yue-Hua, Gao, Jian-Xin, Li, Jing, Guo, Lin, Wu, Cui-Zhen

“…Background and Aim:  Both nuclear factor kappa B (NF‐κB) activation and inducible nitric oxide synthase (iNOS) expression increase in the liver injury, and…”
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Selective degradation of PL2L60 by metabolic stresses‑induced autophagy suppresses multi‑cancer growth by Sun, Lei, Hui, Fu, Tang, Gao-Yan, Shen, Hai-Lian, Cao, Xue-Lei, Gao, Jian-Xin, Li, Lin-Feng

“…It has been reported that PL2L60 proteins, a product of gene which might be activated by an intragenic promoter, could mediate a common pathway specifically…”
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Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1 by Bai, Xiao-Zhi, He, Ting, Gao, Jian-Xin, Liu, Yang, Liu, Jia-Qi, Han, Shi-Chao, Li, Yan, Shi, Ji-Hong, Han, Jun-Tao, Tao, Ke, Xie, Song-Tao, Wang, Hong-Tao, Hu, Da-Hai

“…Acute kidney injury (AKI) is a common complication after severe burns. Melatonin has been reported to protect against multiple organ injuries by increasing the…”
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Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts by Zhu, Hua-Yu, Bai, Wen-Dong, Li, Chao, Zheng, Zhao, Guan, Hao, Liu, Jia-Qi, Yang, Xue-Kang, Han, Shi-Chao, Gao, Jian-Xin, Wang, Hong-Tao, Hu, Da-Hai

“…Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the initiation and progression of keloids…”
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Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice by Duan, Wenrui, Gao, Li, Wu, Xin, Hade, Erinn M, Gao, Jian-Xin, Ding, Haiming, Barsky, Sanford H, Otterson, Gregory A, Villalona-Calero, Miguel A

“…Mutations in the P53 gene are among the most common genetic abnormalities in human lung cancer. Codon 273 in the sequence-specific DNA binding domain is one of…”
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Splenic irradiation combined with tumor irradiation promotes T cell infiltration in the tumor microenvironment and helps in tumor control by Chen, Hai-yan, Xie, Hua-ying, Liu, Xiao-xing, Li, Lin-feng, Bai, Yong-rui, Gao, Jian-xin

“…Locally applied radiation to the tumor is reported to stimulate systemic immune response. During radiotherapy to the abdominal cancer, spleen often receives…”
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