Search Results - "Gao, Guoquan"

Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1 by Xie, Jinye, Xia, Liangping, Xiang, Wei, He, Wenzhuo, Yin, Haofan, Wang, Fang, Gao, Tianxiao, Qi, Weiwei, Yang, Zhonghan, Yang, Xia, Zhou, Ti, Gao, Guoquan

“…Metastatic colorectal cancer (mCRC) patients have poor overall survival despite using irinotecan- or oxaliplatin-based chemotherapy combined with anti-EGFR…”
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High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner by Li, Shuai, Zhou, Ti, Li, Cen, Dai, Zhiyu, Che, Di, Yao, Yachao, Li, Lei, Ma, Jianxing, Yang, Xia, Gao, Guoquan

“…Gastric cancer and breast cancer have a clear tendency toward metastasis and invasion to the microenvironment predominantly composed of adipocytes. Oleic acid…”
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IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice by Li, Lingyi, Ma, Lei, Zhao, Zewei, Luo, Shiya, Gong, Baoyong, Li, Jin, Feng, Juan, Zhang, Hui, Qi, Weiwei, Zhou, Ti, Yang, Xia, Gao, Guoquan, Yang, Zhonghan

“…Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin…”
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High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling by Qi, Weiwei, Yang, Chuan, Dai, Zhiyu, Che, Di, Feng, Juan, Mao, Yuling, Cheng, Rui, Wang, Zhongxiao, He, Xuemin, Zhou, Ti, Gu, Xiaoqiong, Yan, Li, Yang, Xia, Ma, Jian-Xing, Gao, Guoquan

“…Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels of…”
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IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity by Feng, Juan, Li, Lingyi, Ou, Zhiying, Li, Qiao, Gong, Baoyong, Zhao, Zhenxian, Qi, Weiwei, Zhou, Ti, Zhong, Jun, Cai, Weibin, Yang, Xia, Zhao, Aiping, Gao, Guoquan, Yang, Zhonghan

“…Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,…”
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FUBP1 promotes colorectal cancer stemness and metastasis via DVL1‐mediated activation of Wnt/β‐catenin signaling by Yin, Haofan, Gao, Tianxiao, Xie, Jinye, Huang, Zhijian, Zhang, Xiaoyan, Yang, Fengyu, Qi, Weiwei, Yang, Zhonghan, Zhou, Ti, Gao, Guoquan, Yang, Xia

“…Distant metastasis is, unfortunately, the leading cause of death in colorectal cancer (CRC). Approximately 50% of CRC patients develop liver metastases, while…”
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Kallistatin leads to cognition impairment via downregulating glutamine synthetase by Long, Yanlan, Zhao, Zhen, Xie, Wanting, Shi, Jinhui, Yang, Fengyu, Zhu, Dan, Jiang, Ping, Tang, Qilong, Ti, Zhou, Jiang, Bin, Yang, Xia, Gao, Guoquan, Qi, Weiwei

“…In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is considered the basis for cognitive…”
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Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase by Gao, Tianxiao, Huang, Jieye, Yin, Haofan, Huang, Jiajia, Xie, Jinye, Zhou, Ti, Fan, Wei, Yang, Xia, Gao, Guoquan, Li, Zhiming

“…Extranodal NK/T-cell lymphoma (NKTL) is a rare and aggressive form of extranodal lymphoma with a poor prognosis. Currently, there are very limited treatment…”
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PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor by Luo, Chuanghua, Yin, Haofan, Gao, Tianxiao, Ma, Caiqi, Liu, Junxi, Zhang, Ting, Xu, Zumin, Wang, Xi, Zhang, Danrui, Qi, Weiwei, Yang, Zhonghan, Gao, Guoquan, Yang, Xia, Zhou, Ti

“…Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment…”
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Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex by Che, Di, Fang, Zhenzhen, Yan, Li, Du, Jieping, Li, Fangping, Xie, Jinye, Feng, Juan, Yin, Ping, Qi, Weiwei, Yang, Zhonghan, Ma, Jianxing, Yang, Xia, Gao, Guoquan, Zhou, Ti

“…Aims/hypothesis Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is…”
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Identification of a Novel Inhibitor of the Canonical Wnt Pathway by Park, Kyoungmin, Lee, Kyungwon, Zhang, Bin, Zhou, Ti, He, Xi, Gao, Guoquan, Murray, Anne R., Ma, Jian-xing

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model by Xiang, Wei, Li, Longhui, Zhao, Qin, Zeng, Yongcheng, Shi, Jinhui, Chen, Zitong, Gao, Guoquan, Lai, Kunbei

“…Age-related macular degeneration (AMD) is the leading cause of irreversible vision damage among elderly individuals. There is still no efficient treatment for…”
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Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion by Ma, Caiqi, Luo, Chuanghua, Yin, Haofan, Zhang, Yang, Xiong, Wenjun, Zhang, Ting, Gao, Tianxiao, Wang, Xi, Che, Di, Fang, Zhenzhen, Li, Lei, Xie, Jinye, Huang, Mao, Zhu, Liuqing, Jiang, Ping, Qi, Weiwei, Zhou, Ti, Yang, Zhonghan, Wang, Wei, Ma, Jianxing, Gao, Guoquan, Yang, Xia

“…Background Tumor-induced lymphangiogenesis and lymphatic metastasis are predominant during the metastasis of many types of cancers. However, the endogenous…”
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IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1 by Liu, Junxi, Qian, Bingxiu, Zhou, Lin, Shen, Gang, Tan, Yandan, Liu, Siqi, Zhao, Zewei, Shi, Jianglin, Qi, Weiwei, Zhou, Ti, Yang, Xia, Gao, Guoquan, Yang, Zhonghan

“…Interleukin-25 (IL17E/IL25) plays a critical role in colitis and intestinal homeostasis. However, the expression and biological role of IL25 in colorectal…”
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Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor by Zhang, Sarah X, Wang, Joshua J, Gao, Guoquan, Shao, Chunkui, Mott, Robert, Ma, Jian-xing

“…ABSTRACT Pigment epithelium‐derived factor (PEDF) is a potent angiogenic inhibitor. Reduced PEDF levels are associated with diabetic retinopathy. However, the…”
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The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage by Pu, Min, Zhang, Jing, Hong, Fuyan, Wang, Yan, Zhang, Chengwei, Zeng, Yongcheng, Fang, Zhenzhen, Qi, Weiwei, Yang, Xia, Gao, Guoquan, Zhou, Ti

“…Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2…”
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Activation of the Wnt Pathway Plays a Pathogenic Role in Diabetic Retinopathy in Humans and Animal Models by Chen, Ying, Hu, Yang, Zhou, Ti, Zhou, Kevin K, Mott, Robert, Wu, Mingyuan, Boulton, Michael, Lyons, Timothy J, Gao, Guoquan, Ma, Jian-xing

“…Although Wnt signaling is known to mediate multiple biological and pathological processes, its association with diabetic retinopathy (DR) has not been…”
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Combination of pigment epithelium‐derived factor with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by downregulating vascular endothelial growth factor expression and angiogenesis by Xu, Zumin, Fang, Shuhuan, Zuo, Yufang, Zhang, Yang, Cheng, Rui, Wang, Qingsong, Yang, Zhonghan, Cai, Weibin, Ma, Jianxing, Yang, Xia, Gao, Guoquan

“…Nasopharyngeal carcinoma (NPC), which has the highest incidence in South China, is mainly treated by radiotherapy. However, the survival rate remains low…”
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FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma by Jiang, Ping, Huang, Mao, Qi, Weiwei, Wang, Fenghua, Yang, Tianyou, Gao, Tianxiao, Luo, Chuanghua, Deng, Jing, Yang, Zhonghan, Zhou, Ti, Zou, Yan, Gao, Guoquan, Yang, Xia

“…Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the…”
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Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF–VEGF receptor 2 binding in diabetic retinopathy by Zhang, Sarah X, Wang, Joshua J, Gao, Guoquan, Parke, Kyoungmin, Ma, Jian-xing

“…It has been shown that the balance between vascular endothelial growth factor (VEGF), a major angiogenic stimulator, and pigment epithelium-derived factor…”
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