Search Results - "Gao, George Fu"
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A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
Published in Nature (London) (06-08-2020)“…An outbreak of coronavirus disease 2019 (COVID-19) 1 – 3 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 4 , has spread globally…”
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Nanozyme-strip for rapid local diagnosis of Ebola
Published in Biosensors & bioelectronics (15-12-2015)“…Ebola continues to rage in West Africa. In the absence of an approved vaccine or treatment, the priority in controlling this epidemic is to promptly identify…”
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3
NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription
Published in Cell host & microbe (12-11-2014)“…Long noncoding RNAs (lncRNAs) modulate various biological processes, but their role in host antiviral responses is largely unknown. Here we identify a lncRNA…”
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4
Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures
Published in Cell research (01-07-2017)“…Bacteriophages encode anti-CRISPR suppressors to counteract the CRISPR/Cas immunity of their bacterial hosts, thus facilitating their survival and replication…”
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Strengthening the Interaction of the Virology Community with the International Committee on Taxonomy of Viruses (ICTV) by Linking Virus Names and Their Abbreviations to Virus Species
Published in Systematic biology (01-09-2019)“…The International Committee on Taxonomy of Viruses (ICTV) is tasked with classifying viruses into taxa (phyla to species) and devising taxon names. Virus names…”
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Message from the Editor-in-Chief: open science to support global sustainable development
Published in Science bulletin (Beijing) (15-01-2023)Get full text
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Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial
Published in The Lancet infectious diseases (01-01-2021)“…The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates. We aimed to assess the safety and immunogenicity of an inactivated…”
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Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes
Published in Nature protocols (01-07-2018)“…Nanozymes are nanomaterials exhibiting intrinsic enzyme-like characteristics that have increasingly attracted attention, owing to their high catalytic…”
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Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2
Published in Cell (06-08-2020)“…The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health. The…”
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10
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
Published in Nature communications (04-09-2020)“…COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (M pro , also called…”
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A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
Published in Science (American Association for the Advancement of Science) (12-06-2020)“…Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four…”
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12
MicroRNAs: the novel targets for Ebola drugs
Published in Science China. Life sciences (01-10-2014)“…The re-emergence of Ebola viral disease (EVD) in West Africa has caused an international alarm, even panic. As of August 27th, 2014, the Ebola virus (EBOV) has…”
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13
Immune suppression in the early stage of COVID-19 disease
Published in Nature communications (17-11-2020)“…The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is…”
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Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1
Published in Cell (04-08-2022)“…The currently circulating Omicron sub-variants are the SARS-CoV-2 strains with the highest number of known mutations. Herein, we found that human…”
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15
Pseudorabies virus: a neglected zoonotic pathogen in humans?
Published in Emerging microbes & infections (01-01-2019)Get full text
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Integrated metagenomic and metatranscriptomic profiling reveals differentially expressed resistomes in human, chicken, and pig gut microbiomes
Published in Environment international (01-05-2020)“…•A total of 330 ARGs were identified in the 18 human, chicken, and pig fecal samples.•49.4, 66.5, and 56.6% of ARGs identified in human, chicken, and pig gut…”
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Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy
Published in Proceedings of the National Academy of Sciences - PNAS (24-03-2020)“…The programmed cell death 1 (PD-1) receptor on the surface of immune cells is an immune checkpoint molecule that mediates the immune escape of tumor cells…”
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Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants
Published in Nature communications (20-10-2021)“…Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some have been linked to an increase in case numbers globally. However, there is yet a…”
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Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial
Published in The Lancet infectious diseases (01-02-2022)“…Although SARS-CoV-2 infection often causes milder symptoms in children and adolescents, young people might still play a key part in SARS-CoV-2 transmission. An…”
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Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin
Published in The EMBO journal (16-08-2021)“…Pangolins have been suggested as potential reservoir of zoonotic viruses, including SARS‐CoV‐2 causing the global COVID‐19 outbreak. Here, we study the binding…”
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