Search Results - "Gao, Fangye"

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle by Lobbestael, Evy, Zhao, Jing, Rudenko, Iakov N, Beylina, Aleksandra, Gao, Fangye, Wetter, Justin, Beullens, Monique, Bollen, Mathieu, Cookson, Mark R, Baekelandt, Veerle, Nichols, R Jeremy, Taymans, Jean-Marc

“…A cluster of phosphorylation sites in LRRK2 (leucine-rich repeat kinase 2), including Ser910, Ser935, Ser955 and Ser973, is important for PD (Parkinson's…”
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Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant by Daniëls, Veronique, Vancraenenbroeck, Renée, Law, Bernard M. H., Greggio, Elisa, Lobbestael, Evy, Gao, Fangye, De Maeyer, Marc, Cookson, Mark R., Harvey, Kirsten, Baekelandt, Veerle, Taymans, Jean‐Marc

“…J. Neurochem. (2011) 116, 304–315. Mutations in the leucine‐rich repeat kinase 2 (LRRK2) gene are the most prevalent known cause of autosomal dominant…”
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Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers by Civiero, Laura, Vancraenenbroeck, Renée, Belluzzi, Elisa, Beilina, Alexandra, Lobbestael, Evy, Reyniers, Lauran, Gao, Fangye, Micetic, Ivan, De Maeyer, Marc, Bubacco, Luigi, Baekelandt, Veerle, Cookson, Mark R, Greggio, Elisa, Taymans, Jean-Marc

“…Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction domains,…”
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Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart by HEYMANS, Stephane, SCHROEN, Blanche, VAN DE WERF, Frans, PINTO, Yigal M, JANSSENS, Stefan, VERMEERSCH, Pieter, MILTING, Hendrik, GAO, Fangye, KASSNER, Astrid, GILLIJNS, Hilde, HERIJGERS, Paul, FLAMENG, Willem, CARMELIET, Peter

“…Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling…”
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Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis by HEYMANS, Stephane, PAUSCHINGER, Matthias, PADALKO, Elisabeth, NEYTS, Johan, SCHULTHEISS, Heinz-Peter, VAN DE WERF, Frans, CARMELIET, Peter, PINTO, Yigal M, DE PALMA, Armando, KALLWELLIS-OPARA, Angela, RUTSCHOW, Susanne, SWINNEN, Melissa, VANHOUTTE, Davy, FANGYE GAO, TORPAI, Raimund, BAKER, Andrew H

“…Acute viral myocarditis is an important cause of cardiac failure in young adults for which there is no effective treatment apart from general heart failure…”
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Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate by Taymans, Jean-Marc, Gao, Fangye, Baekelandt, Veerle

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Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate by Taymans, Jean-Marc, Gao, Fangye, Baekelandt, Veerle

“…Leucine rich repeat kinases 1 and 2 (LRRK1 and LRRK2) are paralogs which share a similar domain organization, including a serine-threonine kinase domain, a Ras…”
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In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2 by Vancraenenbroeck, Renée, De Raeymaecker, Joren, Lobbestael, Evy, Gao, Fangye, De Maeyer, Marc, Voet, Arnout, Baekelandt, Veerle, Taymans, Jean-Marc

“…Leucine-rich repeat kinase 2 (LRRK2) is a complex, multidomain protein which is considered a valuable target for potential disease-modifying therapeutic…”
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Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant: Mechanistic insight LRRK2 Y1699C by Daniëls, Veronique, Vancraenenbroeck, Renée, Law, Bernard M. H., Greggio, Elisa, Lobbestael, Evy, Gao, Fangye, De Maeyer, Marc, Cookson, Mark R., Harvey, Kirsten, Baekelandt, Veerle, Taymans, Jean-Marc

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