Impaired NK cell functionality and increased TNF-α production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis

Abstract The chronic chikungunya arthritis symptoms closely mimic the rheumatoid arthritis (RA) symptoms, thus making it difficult to distinguish between these two clinical entities. The current comparative study characterizes NK (CD3- CD56+ ) and NK-like T (CD3+ CD56+ ) cell responses in patients w...

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Published in:	Human immunology Vol. 78; no. 4; pp. 370 - 374
Main Authors:	Thanapati, Subrat, Ganu, Mohini, Giri, Prashant, Kulkarni, Shruti, Sharma, Meenal, Babar, Prasad, Ganu, Ashok, Tripathy, Anuradha S
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-04-2017
Subjects:	Adolescent Adult Aged Allergy and Immunology Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - immunology Biomarkers - metabolism Chikungunya Chikungunya Fever - diagnosis Chikungunya Fever - immunology Chikungunya virus - immunology Child Chronic Disease Female Humans Interferon-gamma - metabolism Killer Cells, Natural - physiology Male Middle Aged Natural Killer T-Cells - physiology NK cell NK-like T cell TNF-α Tumor Necrosis Factor-alpha - metabolism Young Adult NK-like T cell TNF-α chikungunya NK cell RA Chikungunya
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Summary:	Abstract The chronic chikungunya arthritis symptoms closely mimic the rheumatoid arthritis (RA) symptoms, thus making it difficult to distinguish between these two clinical entities. The current comparative study characterizes NK (CD3- CD56+ ) and NK-like T (CD3+ CD56+ ) cell responses in patients with chronic chikungunya arthritis and RA. Phenotype and functions of NK and NK-like T cells repertoire were assessed in 56 chronic chikungunya arthritis, 26 RA patients and 82 controls using flow cytometry. TNF-α and IFN-γ-secreting NK-like T cells were high in both chronic arthritis patients than in controls. Percentage of TNF-α+ NK cells was higher in RA patients than in controls. Percentage of perforin+ NK cells was low in both chronic arthritis patient groups. Among the patient groups, expressions of perforin+ and IFN-γ+ NK-like T cells were higher in RA. Overall, our data show reduced frequency of NK-like T cells, lower expression of perforin+ NK, higher expression of TNF-α+ NK-like T and IFN-γ+ NK-like T cells as the markers of chronic arthritic diseases. In the absence of any specific treatment for chronic chikungunya induced arthritis and promising results of anti-TNF-α therapy against RA, current data may form the basis for future in vivo studies and has scope as possible therapeutics against chikungunya.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0198-8859 1879-1166
DOI:	10.1016/j.humimm.2017.02.006