Search Results - "Gantner, N."
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Nitric oxide in cellular adaptation and disease
Published in Redox biology (01-07-2020)“…Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule involved in a wide range of cellular and physiological processes…”
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Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch
Published in Antioxidants & redox signaling (01-04-2020)“…Reactive oxygen species (ROS) are now widely recognized as central mediators of cell signaling. Mitochondria are major sources of ROS. It is now clear that…”
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Are Bitcoin bubbles predictable? Combining a generalized Metcalfe's Law and the Log-Periodic Power Law Singularity model
Published in Royal Society open science (01-06-2019)“…We develop a strong diagnostic for bubbles and crashes in Bitcoin, by analysing the coincidence (and its absence) of fundamental and technical indicators…”
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Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
Published in The Journal of experimental medicine (05-05-2003)“…Toll-like receptors (TLRs) mediate recognition of a wide range of microbial products including lipopolysaccharides, lipoproteins, flagellin, and bacterial DNA,…”
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Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments
Published in The EMBO journal (23-03-2005)“…The ability of Candida albicans to rapidly and reversibly switch between yeast and filamentous morphologies is crucial to pathogenicity, and it is thought that…”
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Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates
Published in Cell (25-08-2006)“…Hematopoietic stem cells and their progenitors exhibit multilineage patterns of gene expression. Molecular mechanisms underlying the generation and refinement…”
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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
Published in Cell reports (Cambridge) (26-03-2024)“…Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone…”
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The Listeria monocytogenes ChiA chitinase enhances virulence through suppression of host innate immunity
Published in mBio (01-05-2013)“…Environmental pathogens survive and replicate within the outside environment while maintaining the capacity to infect mammalian hosts. For some microorganisms,…”
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Map kinase phosphatase 5 protects against sepsis-induced acute lung injury
Published in American journal of physiology. Lung cellular and molecular physiology (01-05-2012)“…Mitogen-activated protein kinases (MAPKs) play a critical role in inflammation. Although activation of MAPK in inflammatory cells has been studied extensively,…”
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Collagen-Specific HSP47 + Myofibroblasts and CD163 + Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections
Published in Journal of the American Heart Association (21-02-2023)“…Background Cardiac fibrosis complicates SARS-CoV-2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of…”
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Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in ex vivo rat liver machine perfusion
Published in Frontiers in transplantation (25-08-2023)“…Machine perfusion is increasingly being utilized in liver transplantation in lieu of traditional cold static organ preservation. Nevertheless, better…”
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SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes
Published in iScience (21-04-2023)“…Suppressor of cytokine signaling-1 (SOCS1) exerts control over inflammation by targeting p65 nuclear factor-κB (NF-κB) for degradation in addition to its…”
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Working with Northern Communities to Build Collaborative Research Partnerships: Perspectives from Early Career Researchers
Published in Arctic (01-09-2014)“…Partnerships between northern communities and academics have existed for decades, yet new attitudes regarding northern scholarship have shifted the research…”
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ROS production by mitochondria: function or dysfunction?
Published in Oncogene (29-01-2024)“…In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions. Reactive oxygen species (ROS), in…”
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Bathymetry and Sediment Geochemistry of Lake Hazen (Quttinirpaaq National Park, Ellesmere Island, Nunavut)
Published in Arctic (01-03-2012)“…Arctic lakes can provide a long-term perspective on environmental change, including trends in long-range atmospheric transport and deposition of contaminants,…”
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Histone oxidation as a new mechanism of metabolic control over gene expression
Published in Trends in genetics (01-09-2024)“…Histone oxidation provides a direct link between metabolically generated reactive oxygen species (ROS) and chromatin architectural changes enabling the…”
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SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer
Published in Proceedings of the National Academy of Sciences - PNAS (19-11-2019)“…Mitochondrial superoxide dismutase (SOD2) suppresses tumor initiation but promotes invasion and dissemination of tumor cells at later stages of the disease…”
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Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling
Published in The Journal of immunology (1950) (15-01-2000)“…Chemokines are likely to play an important role in regulating the trafficking of developing T cells within the thymus. By using anti-CD3varepsilon treatment of…”
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