Search Results - "Gant, Thomas"

Using Deuterium in Drug Discovery: Leaving the Label in the Drug by Gant, Thomas G

“…Deuterium, the stable isotope of hydrogen, is known to medicinal chemists for its utility in mechanistic, spectroscopic, and tracer studies. In fact,…”
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Pilot of urgent care center evaluation for acute coronary syndrome by Radecki, Ryan P, Foley, Kevin F, Elzinga, Timothy S, Horak, Cynthia P, Gant, Thomas E, Papp, Heather M, Morris, Adam J, Hauser, Natalie R, Ertz-Berger, Briar L

“…Patients with chest pain and concern for potential coronary ischemia are frequently referred to the emergency department (ED), resulting in substantial…”
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A crisis planning and monitoring intervention to reduce compulsory hospital readmissions (FINCH study): protocol for a randomised controlled feasibility study by Johnson, Sonia, Birken, Mary, Nyikavaranda, Patrick, Kular, Ariana, Gafoor, Rafael, Parkinson, Jordan, Hutchings-Hay, Chloe, Gant, Thomas, Molai, Jazmin, Rivera, Jessica, Fenwick, James, Bendall, Caroline, Blakley, Louise, Bacarese-Hamilton, Theresa, White, Valerie Christina, Holden, Mark Keith, Seale, Janet, Hardy, Jackie, Fraser, Kathleen Lindsay, Mitchell, Lizzie, Lay, Barbara, Mbeah-Bankas, Henrietta, McCrone, Paul, Freemantle, Nick, Wood, Lisa, Lobban, Fiona, Lloyd-Evans, Brynmor

“…Rates of compulsory (also known as involuntary) detention under mental health legislation have been rising over several decades in countries including England…”
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Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease by Helal, Christopher J., Sanner, Mark A., Cooper, Christopher B., Gant, Thomas, Adam, Mavis, Lucas, John C., Kang, Zhijun, Kupchinsky, Stanley, Ahlijanian, Michael K., Tate, Bonnie, Menniti, Frank S., Kelly, Kristin, Peterson, Marcia

“…[Display omitted] High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide ( 1)…”
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Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists by Lippa, Blaise, Morris, Joel, Corbett, Matthew, Kwan, Tricia A., Noe, Mark C., Snow, Sheri L., Gant, Thomas G., Mangiaracina, Melchiorra, Coffey, Heather A., Foster, Barbara, Knauth, Elisabeth A., Wessel, Matthew D.

“…The design, synthesis, and biological evaluation of potent isothiazole inhibitors of the TrkA kinase is presented. The design, synthesis, and biological…”
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Expression, purification, and enzymatic characterization of the dual specificity mitogen-activated protein kinase phosphatase, MKP-4 by Hong, Suk-Bong, Lubben, Thomas H., Dolliver, Christine M., Petrolonis, Anthony J., Roy, Rebecca A., Li, Zhi, Parsons, Thomas F., Li, Ping, Xu, Haiyan, Reilly, Regina M., Trevillyan, James M., Nichols, Andrew J., Tummino, Peter J., Gant, Thomas G.

“…Mitogen-activated protein kinase phosphatase-4 (MKP-4) is a dual specificity phosphatase, which acts as a negative regulator of insulin-stimulated pathways…”
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Developing the FILL+ Tool to Reliably Classify Classroom Practices Using Lecture Recordings by Kinnear, George, Smith, Steph, Anderson, Ross, Gant, Thomas, MacKay, Jill R D, Docherty, Pamela, Rhind, Susan, Galloway, Ross

“…Lectures are a commonly used teaching method in higher education, but there is significant debate about the relative merits of different classroom practices…”
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Regiospecific synthesis of polysubstituted naphthalenes via oxazoline-mediated nucleophilic aromatic substitutions and additions by Gant, Thomas G, Meyers, A. I

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Comment regarding the stability of active ingredients in long-expired prescription medications by Madden, Michael M, Etzler, Frank M, Gant, Thomas

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A synthesis of various substituted naphthalenones by additions to naphthyloxazolines by Meyers, A. I, Gant, Thomas G

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Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease by Helal, Christopher J., Kang, Zhijun, Lucas, John C., Gant, Thomas, Ahlijanian, Michael K., Schachter, Joel B., Richter, Karl E.G., Cook, James M., Menniti, Frank S., Kelly, Kristin, Mente, Scot, Pandit, Jay, Hosea, Natalie

“…Utilizing structure-based drug design, a 4-aminoimidazole heterocyclic core was synthesized as a replacement for a 2-aminothiazole due to potential…”
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The first enantioselective synthesis of the chemotactic factor sirenin by an intramolecular [2 + 1] cyclization using a new chiral catalyst by Gant, Thomas G., Noe, Mark C., Corey, E.J.

“…A simple, highly enantioselective synthesis of sirenin ( 1) (bioactive form) has been developed which depends on the intramolecular [2 +1] cycloaddition…”
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Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase by PARKER, J. C, VANVOLKENBURG, M. A, VESTERGAARD, P, TREADWAY, J. L, LEVY, C. B, MARTIN, W. H, BURK, S. H, KWON, Y, GIRAGOSSIAN, C, GANT, T. G, CARPINO, P. A, MCPHERSON, R. K

“…Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase. J C Parker , M A VanVolkenburg , C B Levy , W…”
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Resonance Raman scattering studies of gallium-arsenide - aluminum-arsenide superlattices by Gant, Thomas Andrew

“…We have made resonance Raman scattering studies of folded LA phonons and quantized LO phonons in several GaAs-AlAs superlattices. The motivation for this work…”
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Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors by Alam, M, Bechtold, C M, Patick, A K, Skoog, M T, Gant, T G, Colonno, R J, Meyers, A I, Li, H, Trimble, J, Lin, P F

“…A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of…”
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The early enzymatic debridement and grafting of deep dermal burns to the hand by Gant, T D

“…Thirty-four hands in 24 patients with clinically diagnosed, deep second-degree burns have been treated for 24 hours, immediately after the burn with Sutilains…”
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Electrical injuries, with special reference to the upper extremities. A review of 182 cases by Butler, E D, Gant, T D

“…A twenty year experience in the management of 182 patients with electrical injuries has been reviewed. Males predominate. The average age is thirty-six years…”
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Plastic surgery-epitomes of progress: electrical burns by Gant, T D

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Plastic Surgery—Epitomes of Progress by Hentz, Vincent R

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Surgical management of parotid gland tumors by Gant, T D, Hovey, L M, Williams, C

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