Time to Onset of Analgesia and Analgesic Efficacy of Effervescent Acetaminophen 1000 mg Compared to Tablet Acetaminophen 1000 mg in Postoperative Dental Pain: A Single-Dose, Double-Blind, Randomized, Placebo-Controlled Study

Time to Onset of Analgesia and Analgesic Efficacy of Effervescent Acetaminophen 1000 mg Compared to Tablet Acetaminophen 1000 mg in Postoperative Dental Pain: A Single-Dose, Double-Blind, Randomized, Placebo-Controlled Study

This randomized, double‐blind, placebo‐controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg—an effervescent solution and tablet—in 242 patients with moderate or severe pain following dental surgery. Onset of analgesia was de...

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Bibliographic Details
Published in:Journal of clinical pharmacology Vol. 40; no. 4; pp. 370 - 378
Main Authors: Møller, Philip L., Nørholt, Sven E., Ganry, Hervé E., Insuasty, Jorge H., Vincent, Françoise G., Skoglund, Lasse A., Sindet-Pedersen, Steen
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-04-2000
SAGE Publications
Sage Science
Subjects:
Acetaminophen - adverse effects
Acetaminophen - therapeutic use
Adolescent
Adult
Analgesia
Analgesics
Analgesics, Non-Narcotic - adverse effects
Analgesics, Non-Narcotic - therapeutic use
Biological and medical sciences
Double-Blind Method
Dry Socket - chemically induced
Female
Headache - chemically induced
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Pain - chemically induced
Pain Measurement
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
Patient Satisfaction
Pharmacology. Drug treatments
Solutions
Tablets
Time Factors
Tooth Extraction - adverse effects
Treatment Outcome
Human
Postoperative
Dental disease
Single dose
Oral administration
Effervescent form
Analgesia
Chemotherapy
Paracetamol
Analgesic
Pain
Onset time
Treatment
Surgery
Dosage form
Tablet
Tooth
Comparative study
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Summary:This randomized, double‐blind, placebo‐controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg—an effervescent solution and tablet—in 242 patients with moderate or severe pain following dental surgery. Onset of analgesia was determined using a two‐stopwatch procedure. Analgesia was assessed over a 4‐hour period. Treatments were compared using standard indexes of pain intensity and pain relief and summary measures. Both acetaminophen formulations were significantly more effective than their corresponding placebo for all efficacy assessments. The median time to onset of analgesia was significantly shorter with effervescent acetaminophen (20 minutes) compared to tablet acetaminophen (45 minutes). During the first 45 minutes after administration, effervescent acetaminophen was significantly more effective at each scheduled assessment time than tablet acetaminophen. The median time to meaningful pain relief was significantly shorter with effervescent acetaminophen (45 minutes) compared to tablet acetaminophen (60 minutes). At 4 hours after administration, the pain relief was significantly better with tablet acetaminophen than with effervescent acetaminophen. No other significant differences were observed between the active treatments. In conclusion, effervescent acetaminophen produces a significantly faster onset of analgesia than tablet acetaminophen.
Bibliography:istex:FF8E078B4D5746CD3F530CC403EFD6C1696E0BDE
ark:/67375/WNG-SJR9MBDR-8
ArticleID:JCPH758
ISSN:0091-2700
1552-4604
DOI:10.1177/00912700022009071