Search Results - "Gannon, Olivia"

Contributions of sex to cerebrovascular function and pathology by Robison, Lisa S., Gannon, Olivia J., Salinero, Abigail E., Zuloaga, Kristen L.

“…[Display omitted] •Sex differences exist in cerebrovascular function and pathology, with many effects mediated by sex hormones.•Throughout most of the…”
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High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner by Gannon, Olivia J, Robison, Lisa S, Salinero, Abigail E, Abi-Ghanem, Charly, Mansour, Febronia M, Kelly, Richard D, Tyagi, Alvira, Brawley, Rebekah R, Ogg, Jordan D, Zuloaga, Kristen L

“…Approximately 70% of Alzheimer's disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent…”
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Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease by Robison, Lisa S, Gannon, Olivia J, Thomas, Melissa A, Salinero, Abigail E, Abi-Ghanem, Charly, Poitelon, Yannick, Belin, Sophie, Zuloaga, Kristen L

“…Abstract Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding…”
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Sex‐specific effects of high‐fat diet on cognitive impairment in a mouse model of VCID by Salinero, Abigail E., Robison, Lisa S., Gannon, Olivia J., Riccio, David, Mansour, Febronia, Abi‐Ghanem, Charly, Zuloaga, Kristen L.

“…Mid‐life metabolic disease (ie, obesity, diabetes, and prediabetes) causes vascular dysfunction and is a risk factor for vascular contributions to cognitive…”
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Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues by Li, Jia, Chen, Shu, Cleary, Rachel A, Wang, Ruping, Gannon, Olivia J, Seto, Edward, Tang, Dale D

“…Histone deacetylases (HDACs) are a family of enzymes that mediate nucleosomal histone deacetylation and gene expression. Some members of the HDAC family have…”
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Effects of high fat diet on metabolic health vary by age of menopause onset by Salinero, Abigail E, Venkataganesh, Harini, Abi-Ghanem, Charly, Riccio, David, Kelly, Richard D, Gannon, Olivia J, Sura, Avi, Brooks, Heddwen L, Zuloaga, Damian G, Zuloaga, Kristen L

“…Menopause accelerates metabolic dysfunction, including (pre-)diabetes, obesity and visceral adiposity. However, the effects of endocrine vs. chronological…”
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Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle by Li, Jia, Wang, Ruping, Gannon, Olivia J., Rezey, Alyssa C., Jiang, Sixin, Gerlach, Brennan D., Liao, Guoning, Tang, Dale D.

“…Polo-like kinase 1 (Plk1) is a serine/threonine-protein kinase that has been implicated in mitosis, cytokinesis, and smooth muscle cell proliferation. The role…”
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Recruitment of β-Catenin to N-Cadherin Is Necessary for Smooth Muscle Contraction by Wang, Tao, Wang, Ruping, Cleary, Rachel A., Gannon, Olivia J., Tang, Dale D.

“…β-Catenin is a key component that connects transmembrane cadherin with the actin cytoskeleton at the cell-cell interface. However, the role of the…”
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Treatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice by Salinero, Abigail E., Abi-Ghanem, Charly, Venkataganesh, Harini, Sura, Avi, Smith, Rachel M., Thrasher, Christina A., Kelly, Richard D., Hatcher, Katherine M., NyBlom, Vanessa, Shamlian, Victoria, Kyaw, Nyi-Rein, Belanger, Kasey M., Gannon, Olivia J., Stephens, Shannon B.Z., Zuloaga, Damian G., Zuloaga, Kristen L.

“…Menopause is an endocrine shift leading to increased vulnerability for cognitive impairment and dementia risk factors, in part due to loss of neuroprotective…”
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Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia by Gannon, Olivia J, Naik, Janvie S, Riccio, David, Mansour, Febronia M, Abi-Ghanem, Charly, Salinero, Abigail E, Kelly, Richard D, Brooks, Heddwen L, Zuloaga, Kristen L

“…The vast majority of women with dementia are post-menopausal. Despite clinical relevance, menopause is underrepresented in rodent models of dementia. Before…”
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Menopause Diminishes Female Protection against Vascular Contributions to Cognitive Impairment and Dementia by Gannon, Olivia J., Naik, Janvie S., Abi‐Ghanem, Charly, Mansour, Febronia, Salinero, Abigail E., Riccio, David, Kelly, Richard D., Brooks, Heddwen L., Zuloaga, Kristen L.

“…Around mid‐life, ovarian production of estrogen stops in a sex‐specific endocrine transition called menopause. While most women who have dementia are…”
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High-Fat Diet-Induced Obesity Causes Sex-Specific Deficits in Adult Hippocampal Neurogenesis in Mice by Robison, Lisa S, Albert, Nathan M, Camargo, Lauren A, Anderson, Brian M, Salinero, Abigail E, Riccio, David A, Abi-Ghanem, Charly, Gannon, Olivia J, Zuloaga, Kristen L

“…Adult hippocampal neurogenesis (AHN) is suppressed by high-fat (HF) diet and metabolic disease, including obesity and type 2 diabetes. Deficits in AHN may…”
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Effects of menopause on cognitive deficits in a mouse model of metabolic disease by Salinero, Abigail E, Abi‐Ghanem, Charly, Kelly, Richard D, Riccio, David, Gannon, Olivia J, Venkataganesh, Harini, Zuloaga, Kristen L

“…Background By 2025, it is estimated that nearly 20% of the U.S. population will be post‐menopausal women. Menopause accelerates metabolic disease, a major…”
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Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease by Robison, Lisa S, Gannon, Olivia J, Salinero, Abigail E, Abi-Ghanem, Charly, Kelly, Richard D, Riccio, David A, Mansour, Febronia M, Zuloaga, Kristen L

“…Alzheimer's disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas; however, several…”
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Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID by Abi-Ghanem, Charly, Salinero, Abigail E, Kordit, David, Mansour, Febronia M, Kelly, Richard D, Venkataganesh, Harini, Kyaw, Nyi-Rein, Gannon, Olivia J, Riccio, David, Fredman, Gabrielle, Poitelon, Yannick, Belin, Sophie, Kopec, Ashley M, Robison, Lisa S, Zuloaga, Kristen L

“…Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads…”
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The impacts of menopause on a mouse model of co‐morbid metabolic syndrome and Alzheimer’s disease by Abi‐Ghanem, Charly, Salinero, Abigail E, Gannon, Olivia J, Riccio, David, Mansour, Febronia, Kelly, Richard D, Kordit, David, Wang, Matthew, Kyaw, Nyi‐Rein, Cirrito, John R, Zuloaga, Kristen L

“…Background Alzheimer’s disease (AD) is the leading cause of disability and 5th cause of death in people over 65 years of age. Approximately 2/3 of AD patients…”
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Reply to "Letter to the editor: 'KDAC and the regulation of nonnuclear smooth muscle protein acetylation'" by Tang, Dale D, Cleary, Rachel A, Wang, Ruping, Gannon, Olivia J

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Angiotensin II‐mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats by Gannon, Olivia, Tremble, Sarah M., McGinn, Conor, Guth, Ruby, Scoppettone, Nadia, Hunt, Ryan D., Prakash, Kirtika, Johnson, Abbie C.

“…INTRODUCTION Chronic hypertension increases the risk of vascular cognitive impairment (VCI) by ∼60%; however, how hypertension affects the vasculature of the…”
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Role of sex and diet in hypothalamic disturbances in wild‐type mice and the 3xTg‐AD mouse model of familial Alzheimer’s disease by Robison, Lisa S, Gannon, Olivia J, Salinero, Abigail E, Thomas, Melissa A, Zuloaga, Kristen L

“…Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding behavior…”
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Role of sex and diet in hypothalamic disturbances in wild‐type mice and the 3xTg‐AD mouse model of familial Alzheimer’s disease: Developing topics by Robison, Lisa S, Gannon, Olivia J, Salinero, Abigail E, Thomas, Melissa A, Zuloaga, Kristen L

“…Abstract Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding…”
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