Search Results - "Gannon, K. S."

Phototransduction in Transgenic Mice after Targeted Deletion of the Rod Transducin α-Subunit by Calvert, P. D., Krasnoperova, N. V., Lyubarsky, A. L., Isayama, T., Nicoló, M., Kosaras, B., Wong, G., Gannon, K. S., Margolskee, R. F., Sidman, R. L., Pugh, E. N., Makino, C. L., Lem, J.

“…Retinal photoreceptors use the heterotrimeric G protein transducin to couple rhodopsin to a biochemical cascade that underlies the electrical photoresponse…”
Get full text

Transduction of bitter and sweet taste by gustducin by Wong, Gwendolyn T, Gannon, Kimberley S, Margolskee, Robert F

“…Several lines of evidence suggest that both sweet and bitter tastes are transduced via receptors coupled to heterotrimeric guanine-nucleotide-binding proteins…”
Get full text

A Novel Augmentation Strategy for Treating Resistant Major Depression by Shelton, Richard C., Tollefson, Gary D., Tohen, Mauricio, Stahl, Stephen, Gannon, Kimberley S., Jacobs, Thomas G., Buras, William R., Bymaster, Frank P., Zhang, Wei, Spencer, Kimberley A., Feldman, Peter D., Meltzer, Herbert Y.

“…OBJECTIVE: Treatment-resistant depression is a significant public health concern; drug switching or augmentation often produce limited results. The authors…”
Get full text

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model by Paul, Steven M, Dodart, Jean-Cosme, Bales, Kelly R, Gannon, Kimberley S, Greene, Stephen J, DeMattos, Ronald B, Mathis, Chantal, DeLong, Cynthia A, Wu, Su, Wu, Xin, Holtzman, David M

“…We have previously shown that chronic treatment with the monoclonal antibody m266, which is specific for amyloid beta -peptide (A beta ), increases plasma…”
Get full text

Sodium intake linked to amiloride-sensitive gustatory transduction in C57BL/6J and 129/J mice by GANNON, K. S, CONTRERAS, R. J

“…Mice of 129/J and C57BL/6J inbred strains received two-bottle, 48-h preference tests of NaCl solutions vs. distilled water. 129/J mice exhibited a greater…”
Get full text

Holeboard discrimination learning in mice by Kuc, K. A., Gregersen, B. M., Gannon, K. S., Dodart, J.‐C.

“…We have adapted to mice a holeboard‐learning task, which allows simultaneous assessment of spatial working and reference‐memory performance. The holeboard…”
Get full text

Investigation of intrathecal transport of NPT002, a prospective therapeutic based on phage M13, in nonhuman primates by Papisov, Mikhail I., Belov, V., Belova, E., Fischman, A. J., Fisher, R., Wright, J. L., Gannon, K. S., Titus, J., Gagne, M., Gillooly, C. A.

“…Presently, there are no effective treatments for conditions characterized by protein misfolding, such as Alzheimer’s, Parkinson’s, and other diseases involving…”
Get full text

Thirst and salt appetite induced by hypovolemia in rats: analysis of drinking behavior by Stricker, E M, Gannon, K S, Smith, J C

“…A detailed description of the increased intake of water and 0.5 M NaCl solution by rats after colloid-induced hypovolemia was obtained by measuring drinking…”
Get more information

Hot topics in behavioral and neural genetics by Williams, R. W., Dubnau, J., Enoch, M.‐A., Flaherty, L., Sluyter, F., Gannon, K. S., Maxson, S. C., Riedl, C. A. L., Williams, K. D., Holmes, A., Bolivar, V. J., Crusio, W. E.

Get full text

Biochemical and transgenic analysis of gustducin's role in bitter and sweet transduction by Wong, G T, Ruiz-Avila, L, Ming, D, Gannon, K S, Margolskee, R F

Get more information

Salt appetite induced by DOCA treatment or adrenalectomy in rats: analysis of ingestive behavior by Stricker, E M, Gannon, K S, Smith, J C

“…A detailed description of the increased intake of 0.5 M NaCl solution by rats after systemic treatment with desoxycorticosterone acetate (DOCA) or after…”
Get more information

Ingestion patterns of food, water, saccharin and sucrose in streptozotocin-induced diabetic rats by Smith, J C, Gannon, K S

“…Changes in preference for sweet tasting solutions have previously been reported in diabetic rats. The present study was designed to use detailed analyses of…”
Get more information

Sucrose octaacetate tasting in a heterogeneous population of CFW mice by GANNON, K. S, WHITNEY, G

“…Three experiments investigated the genetic underpinnings of the sucrose octaacetate (SOA) avoidance-indifference dimorphism that exists among outbred CFW mice…”
Get full text

The B6.SW bilineal congenic sucrose octaacetate (SOA)-taster mice by WHITNEY, G, HARDER, D. B, GANNON, K. S

“…SWR/J inbred mice (Tasters) reliably avoid, whereas C57BL/6J inbred mice (Nontasters) are indifferent to, sucrose octaacetate (SOA) at certain concentrations…”
Get full text

SW.B6-Soa(b) nontaster congenic strains completed and a sucrose octaacetate congenic quartet tested with other bitters by Harder, D B, Gannon, K S, Whitney, G

“…Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inbred strain were bred via repeated backcross-intercross cycles, with selection for…”
Get full text

A system for studying the microstructure of ingestive behavior in mice by Gannon, K S, Smith, J C, Henderson, R, Hendrick, P

“…A system for long-term monitoring of mouse eating and drinking behavior with 6-s resolution is described. The apparatus utilizes infrared beams to monitor…”
Get more information

PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety by Brunelli, Susan A., Aviles, Jessica A., Gannon, Kimberly S., Branscomb, Aron, Shacham, Sharon

“…To address the development of early anxiety disorders across the lifespan, the High USV line of rats was bred based on rates of infant ultrasonic vocalization…”
Get full text

Techniques: Holeboard discrimination learning in mice by Kuc, KA, Gregersen, B M, Gannon, K S, Dodart, J-C

“…We have adapted to mice a holeboard-learning task, which allows simultaneous assessment of spatial working and reference-memory performance. The holeboard…”
Get full text

Combination of sub-threshold doses of Aricept and PRX-07034, a novel 5-HT6 receptor antagonist, enhances Novel Object Discrimination (NOD) memory by MV King, KCF Fone, S Shacham, M Fichman, R Melendez, P Orbach, KS Gannon

Get full text

PRX-07034, a Potent and Selective 5-HT6 Receptor Antagonist, Reduces Food Intake and Body Weight in Rats by KS Gannon, DJ Heal, SC Cheetham, HC Jackson, RJ Seeley, R Melendez, M Fichman, JV Rutkowski, S Shacham, P Orbach

Get full text