Search Results - "Ganley, Robert P"

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia by Boyle, Kieran A, Gradwell, Mark A, Yasaka, Toshiharu, Dickie, Allen C, Polgár, Erika, Ganley, Robert P, Orr, Desmond P H, Watanabe, Masahiko, Abraira, Victoria E, Kuehn, Emily D, Zimmerman, Amanda L, Ginty, David D, Callister, Robert J, Graham, Brett A, Hughes, David I

“…Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal…”
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c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy by Frezel, Noémie, Ranucci, Matteo, Foster, Edmund, Wende, Hagen, Pelczar, Pawel, Mendes, Raquel, Ganley, Robert P., Werynska, Karolina, d’Aquin, Simon, Beccarini, Camilla, Birchmeier, Carmen, Zeilhofer, Hanns Ulrich, Wildner, Hendrik

“…Corticospinal tract (CST) neurons innervate the deep spinal dorsal horn to sustain chronic neuropathic pain. The majority of neurons targeted by the CST are…”
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A combined electrophysiological and morphological study of neuropeptide Y–expressing inhibitory interneurons in the spinal dorsal horn of the mouse by Iwagaki, Noboru, Ganley, Robert P., Dickie, Allen C., Polgár, Erika, Hughes, David I., Del Rio, Patricia, Revina, Yulia, Watanabe, Masahiko, Todd, Andrew J., Riddell, John S.

“…The spinal dorsal horn contains numerous inhibitory interneurons that control transmission of somatosensory information. Although these cells have important…”
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Structural MRI Reveals Cervical Spinal Cord Atrophy in the P301L Mouse Model of Tauopathy: Gender and Transgene-Dosing Effects by Sartoretti, Thomas, Ganley, Robert P, Ni, Ruiqing, Freund, Patrick, Zeilhofer, Hanns Ulrich, Klohs, Jan

“…In primary tauopathies, the deposition of tau neurofibrillary tangles and threads as well as neurodegenerative changes have been found within the brain and…”
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A phospho‐deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons by Werynska, Karolina, Neumann, Elena, Cramer, Teresa, Ganley, Robert P., Gingras, Jacinthe, Zeilhofer, Hanns Ulrich

“…Abstract Glycine receptors (GlyRs), together with GABA A receptors, mediate postsynaptic inhibition in most spinal cord and hindbrain neurons. In several CNS…”
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Targeting the interaction of GABAB receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices by Balakrishnan, Karthik, Hleihil, Mohammad, Bhat, Musadiq A., Ganley, Robert P., Vaas, Markus, Klohs, Jan, Zeilhofer, Hanns Ulrich, Benke, Dietmar

“…Cerebral ischemia is the leading cause for long‐term disability and mortality in adults due to massive neuronal death. Currently, there is no pharmacological…”
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Targeting the interaction of GABA B receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices by Balakrishnan, Karthik, Hleihil, Mohammad, Bhat, Musadiq A, Ganley, Robert P, Vaas, Markus, Klohs, Jan, Zeilhofer, Hanns Ulrich, Benke, Dietmar

“…Cerebral ischemia is the leading cause for long-term disability and mortality in adults due to massive neuronal death. Currently, there is no pharmacological…”
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Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold by Albisetti, Gioele W., Ganley, Robert P., Pietrafesa, Francesca, Werynska, Karolina, Magalhaes de Sousa, Marília, Sipione, Rebecca, Scheurer, Louis, Bösl, Michael R., Pelczar, Pawel, Wildner, Hendrik, Zeilhofer, Hanns Ulrich

“…Proper sensing of ambient temperature is of utmost importance for the survival of euthermic animals, including humans. While considerable progress has been…”
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Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction by Ganley, Robert P, Werder, Kira, Wildner, Hendrik, Zeilhofer, Hanns Ulrich

“…Background The locus coeruleus (LC) is the principal source of noradrenaline (NA) in the central nervous system. Projection neurons in the ventral portion of…”
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Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets by Ganley, Robert P, Iwagaki, Noboru, del Rio, Patricia, Baseer, Najma, Dickie, Allen C, Boyle, Kieran A, Polgár, Erika, Watanabe, Masahiko, Abraira, Victoria E, Zimmerman, Amanda, Riddell, John S, Todd, Andrew J

“…The superficial dorsal horn of the spinal cord contains numerous inhibitory interneurons, which regulate the transmission of information perceived as touch,…”
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