Search Results - "Ganley, Ian G."

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest by Ganley, Ian G., Wong, Pui-Mun, Gammoh, Noor, Jiang, Xuejun

“…Autophagy, a catabolic pathway that delivers cellular components to lysosomes for degradation, can be activated by stressful conditions such as nutrient…”
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Mammalian mitophagy – from in vitro molecules to in vivo models by Rodger, Catherine E., McWilliams, Thomas G., Ganley, Ian G.

“…The autophagic turnover of mitochondria, termed mitophagy, is thought to play an essential role in not only maintaining the health of the mitochondrial network…”
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MTOR, PIK3C3, and autophagy: Signaling the beginning from the end by Munson, Michael J, Ganley, Ian G

“…A key point in starvation-induced autophagy occurs at the end of the process, where lysosomes are regenerated from autolysosomes through a pathway termed…”
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Loss of iron triggers PINK1/Parkin-independent mitophagy by Allen, George F G, Toth, Rachel, James, John, Ganley, Ian G

“…In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour…”
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Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys by Livingston, Man J., Wang, Jinghong, Zhou, Jiliang, Wu, Guangyu, Ganley, Ian G., Hill, Joseph A., Yin, Xiao-Ming, Dong, Zheng

“…Ischemic preconditioning (IPC) affords tissue protection in organs including kidneys; however, the underlying mechanism remains unclear. Here we demonstrate an…”
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mito-QC illuminates mitophagy and mitochondrial architecture in vivo by McWilliams, Thomas G, Prescott, Alan R, Allen, George F G, Tamjar, Jevgenia, Munson, Michael J, Thomson, Calum, Muqit, Miratul M K, Ganley, Ian G

“…Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential quality-control (QC) mechanism of pathophysiological relevance in…”
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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy by Ganley, Ian G., Lam, Du H., Wang, Junru, Ding, Xiaojun, Chen, She, Jiang, Xuejun

“…Autophagy is a degradative process that recycles long-lived and faulty cellular components. It is linked to many diseases and is required for normal…”
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Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy by Petherick, Katy J., Conway, Owen J.L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.

“…Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of…”
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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase by Bago, Ruzica, Malik, Nazma, Munson, Michael J, Prescott, Alan R, Davies, Paul, Sommer, Eeva, Shpiro, Natalia, Ward, Richard, Cross, Darren, Ganley, Ian G, Alessi, Dario R

“…The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to…”
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Semi-automated quantitation of mitophagy in cells and tissues by Montava-Garriga, Lambert, Singh, François, Ball, Graeme, Ganley, Ian G.

“…•The mito-QC reporter is a powerful model to monitor mitophagy in vitro and in vivo.•The mito-QC Counter is a new semi-automated tool to quantify…”
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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System by Simpson, Luke M, Macartney, Thomas J, Nardin, Alice, Fulcher, Luke J, Röth, Sascha, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Ganley, Ian G, Sapkota, Gopal P

“…The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3…”
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Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice by Singh, Francois, Prescott, Alan R, Rosewell, Philippa, Ball, Graeme, Reith, Alastair D, Ganley, Ian G

“…Parkinson's disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood…”
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Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification? by Phadwal, Kanchan, Vrahnas, Christina, Ganley, Ian G, MacRae, Vicky E

“…Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells, which can generate and sequester toxic reactive oxygen species (ROS) in…”
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A comparative map of macroautophagy and mitophagy in the vertebrate eye by McWilliams, Thomas G., Prescott, Alan R., Villarejo-Zori, Beatriz, Ball, Graeme, Boya, Patricia, Ganley, Ian G.

“…Photoreception is pivotal to our experience and perception of the natural world; hence the eye is of prime importance for most vertebrate animals to sense…”
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Autophagosome maturation and lysosomal fusion by Ganley, Ian G

“…Compartmentalization is essential in the eukaryotic cell and this is most often achieved by sequestering specific components that perform a related function in…”
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syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells by Ganley, Ian G, Espinosa, Eric, Pfeffer, Suzanne R

“…Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process…”
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p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification by Phadwal, Kanchan, Tang, Qi-Yu, Luijten, Ineke, Zhao, Jin-Feng, Corcoran, Brendan, Semple, Robert K, Ganley, Ian G, MacRae, Vicky E

“…Arterial calcification is an important characteristic of cardiovascular disease. It has key parallels with skeletal mineralization; however, the underlying…”
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Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model by Fang, Tracy-Shi Zhang, Sun, Yu, Pearce, Andrew C., Eleuteri, Simona, Kemp, Mark, Luckhurst, Christopher A., Williams, Rachel, Mills, Ross, Almond, Sarah, Burzynski, Laura, Márkus, Nóra M., Lelliott, Christopher J., Karp, Natasha A., Adams, David J., Jackson, Stephen P., Zhao, Jin-Feng, Ganley, Ian G., Thompson, Paul W., Balmus, Gabriel, Simon, David K.

“…Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic…”
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Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes by Ivy, Jessica R., Carter, Roderic N., Zhao, Jin‐Feng, Buckley, Charlotte, Urquijo, Helena, Rog‐Zielinska, Eva A., Panting, Emma, Hrabalkova, Lenka, Nicholson, Cara, Agnew, Emma J., Kemp, Matthew W., Morton, Nicholas M., Stock, Sarah J., Wyrwoll, Caitlin, Ganley, Ian G., Chapman, Karen E.

“…The late gestational rise in glucocorticoids contributes to the structural and functional maturation of the perinatal heart. Here, we hypothesized that…”
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GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling by Stretton, Clare, Hoffmann, Thorsten M, Munson, Michael J, Prescott, Alan, Taylor, Peter M, Ganley, Ian G, Hundal, Harinder S

“…The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates…”
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