Search Results - "Gangwal, Rahul"

Oral delivery of anticancer drugs: Challenges and opportunities by Thanki, Kaushik, Gangwal, Rahul P., Sangamwar, Abhay T., Jain, Sanyog

“…The present report focuses on the various aspects of oral delivery of anticancer drugs. The significance of oral delivery in cancer therapeutics has been…”
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Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: Synthesis, biological evaluation and docking studies by Bhandari, Pamita, Patel, Neeraj Kumar, Gangwal, Rahul P., Sangamwar, Abhay T., Bhutani, Kamlesh Kumar

“…A series of oleanolic acid analogs, characterized by structural modifications at position C-3 and C-28 of oleanane skeleton were synthesized and assessed for…”
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A PPAR-β/δ agonist is neuroprotective and decreases cognitive impairment in a rodent model of Parkinson's disease by Das, Nihar R, Gangwal, Rahul P, Damre, Mangesh V, Sangamwar, Abhay T, Sharma, Shyam S

“…Parkinson's disease (PD) is associated with higher risk of cognitive impairment that may lead to memory loss, confusion, and decreased attention span. In this…”
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Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling by Kaur, Navpreet, Thakur, Poonam Singh, Shete, Ganesh, Gangwal, Rahul, Sangamwar, Abhay T., Bansal, Arvind Kumar

“…Poorly soluble weak bases form a significant proportion of the drugs available in the market thereby making it imperative to understand their absorption…”
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Characterization of degradation products of Ivabradine by LC-HR-MS/MS: a typical case of exhibition of different degradation behaviour in HCl and H2SO4 acid hydrolysis by Patel, Prinesh N., Borkar, Roshan M., Kalariya, Pradipbhai D., Gangwal, Rahul P., Sangamwar, Abhay T., Samanthula, Gananadhamu, Ragampeta, Srinivas

“…A validated stability‐indicating HPLC method was established, and comprehensive stress testing of ivabradine, a cardiotonic drug, was carried out as per ICH…”
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Leucine-684: A conserved residue of an AMP-acetyl CoA synthetase (AceCS) from Leishmania donovani is involved in substrate recognition, catalysis and acetylation by Soumya, Neelagiri, Tandan, Hitendra, Damre, Mangesh V., Gangwal, Rahul P., Sangamwar, Abhay T., Singh, Sushma

“…AMP-acetyl CoA synthetase (AMP-AceCS) is a key enzyme which catalyzes the activation of acetate to acetyl CoA, an important intermediate at the cross roads of…”
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A combined ligand and structure based approach to design potent PPAR-alpha agonists by Dhoke, Gaurao V., Gangwal, Rahul P., Sangamwar, Abhay T.

“…► Ligand and structure based pharmacophore model was developed for PPAR-alpha agonists. ► The developed pharmacophore model was validated with multiple…”
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Effect of different "states" of sorbed water on amorphous celecoxib by Shete, Ganesh, Kuncham, Swathi, Puri, Vibha, Gangwal, Rahul P, Sangamwar, Abhay T, Bansal, Arvind Kumar

“…Glass transition temperature (Tg) of an amorphous drug is a vital physical phenomenon that influences its visco-elastic properties, physical, and chemical…”
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p38 Mitogen-activated protein kinase inhibitors: a review on pharmacophore mapping and QSAR studies by Gangwal, Rahul P, Bhadauriya, Anuseema, Damre, Mangesh V, Dhoke, Gaurao V, Sangamwar, Abhay T

“…p38 mitogen-activated protein (MAP) kinases are the serine/threonine protein kinases, which play a vital role in cellular responses to external stress signals…”
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A combined pharmacophore modeling, 3D-QSAR and molecular docking study of substituted bicyclo-[3.3.0]oct-2-enes as liver receptor homolog-1 (LRH-1) agonists by Lalit, Manisha, Gangwal, Rahul P., Dhoke, Gaurao V., Damre, Mangesh V., Khandelwal, Kanchan, Sangamwar, Abhay T.

“…•Ligand based pharmacophore model was developed and validated for LRH-1 agonists.•Three different databases were screened by means of validated pharmacophore…”
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Neuroprotective Potential of Peroxisome Proliferator Activated Receptor-α Agonist in Cognitive Impairment in Parkinson's Disease: Behavioral, Biochemical, and PBPK Profile by Sangamwar, Abhay T., Damre, Mangesh V., Gangwal, Rahul P., Das, Nihar R., Uppalapati, Dedeepya, Sharma, Shyam S.

“…Parkinson’s disease (PD) is a common neurodegenerative disorder affecting 1% of the population by the age of 65 years and 4-5% of the population by the age of…”
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Identification of p38α MAP kinase inhibitors by pharmacophore based virtual screening by Gangwal, Rahul P., Das, Nihar R., Thanki, Kaushik, Damre, Mangesh V., Dhoke, Gaurao V., Sharma, Shyam S., Jain, Sanyog, Sangamwar, Abhay T.

“…•Bioactive confirmations were used to develop and validate pharmacophore hypotheses.•A combined pharmacophore model was designed to identify novel p38 MAP…”
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Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-α (PPAR-α) agonists by Gangwal, Rahul P, Damre, Mangesh V, Das, Nihar R, Sharma, Shyam S, Sangamwar, Abhay T

“…Peroxisome proliferator activated receptors-α (PPAR-α) control the expression of several genes involved in diseases like diabetes, hyperlipidaemia, and…”
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3D QSAR pharmacophore-based virtual screening and molecular docking studies to identify novel matrix metalloproteinase 12 inhibitors by Singh, Udghosh, Gangwal, Rahul P., Prajapati, Rameshwar, Dhoke, Gaurao V., Sangamwar, Abhay T.

“…Matrix metalloproteinase 12 (MMP-12) is a potential therapeutic target for the treatment of chronic obstructive pulmonary disorder and other inflammatory…”
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Identification of dual Acetyl-CoA carboxylases 1 and 2 inhibitors by pharmacophore based virtual screening and molecular docking approach by Bhadauriya, Anuseema, Dhoke, Gaurao V., Gangwal, Rahul P., Damre, Mangesh V., Sangamwar, Abhay T.

“…Acetyl-CoA carboxylase (ACC) is a crucial metabolic enzyme that plays a vital role in obesity-induced type 2 diabetes and fatty acid metabolism. To identify…”
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Structure based virtual screening to identify selective phosphodiesterase 4B inhibitors by Gangwal, Rahul P., Damre, Mangesh V., Das, Nihar R., Dhoke, Gaurao V., Bhadauriya, Anuseema, Varikoti, Rohith A., Sharma, Shyam S., Sangamwar, Abhay T.

“…•Ligand based pharmacophore models were developed for PDE4B and PDE4D inhibitors.•The developed pharmacophore model was validated by multiple approaches.•Three…”
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IPAT: a freely accessible software tool for analyzing multiple patent documents with inbuilt landscape visualizer by Ajay, Dara, Gangwal, Rahul P, Sangamwar, Abhay T

“…Intelligent Patent Analysis Tool (IPAT) is an online data retrieval tool, operated based on text mining algorithm to extract specific patent information in a…”
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3D-QSAR and molecular docking analysis of (4-piperidinyl)-piperazines as acetyl-CoA carboxylases inhibitors by Singh, Udghosh, Gangwal, Rahul Prakashchand, Dhoke, Gaurao V., Prajapati, Rameshwar, Damre, Mangesh, Sangamwar, Abhay T.

“…Acetyl-CoA carboxylase (ACC) is a crucial metabolic enzyme, which plays a vital role in fatty acid metabolism and obesity induced type 2 diabetes. Herein, we…”
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Synthesis, biological evaluation and 3D-QSAR study of hydrazide, semicarbazide and thiosemicarbazide derivatives of 4-(adamantan-1-yl)quinoline as anti-tuberculosis agents by Patel, Sanjay R., Gangwal, Rahul, Sangamwar, Abhay T., Jain, Rahul

“…We report synthesis, anti-tuberculosis activity and 3D-QSAR study of forty nine hydrazide, semicarbazide and thiosemicarbazide derivatives of…”
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Synthesis, biological evaluation and 3D QSAR study of 2,4-disubstituted quinolines as anti-tuberculosis agents by Patel, Sanjay R., Gangwal, Rahul, Sangamwar, Abhay T., Jain, Rahul

“…The synthesis and anti-tuberculosis activity for three series of 2,4-disubstituted quinolines is reported. The synthesized compounds were evaluated for…”
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