Search Results - "Gangurde, Pranoti"

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy by Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K

“…Stapled α−helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we report a potent and selective dual…”
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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells by Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie

“…KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates…”
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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development by Guerlavais, Vincent, Sawyer, Tomi K., Carvajal, Luis, Chang, Yong S., Graves, Bradford, Ren, Jian-Guo, Sutton, David, Olson, Karen A., Packman, Kathryn, Darlak, Krzysztof, Elkin, Carl, Feyfant, Eric, Kesavan, Kamala, Gangurde, Pranoti, Vassilev, Lyubomir T., Nash, Huw M., Vukovic, Vojislav, Aivado, Manuel, Annis, D. Allen

“…We report the discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-helical peptide to enter clinical trials. ALRN-6924 is a “stapled…”
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PERSISTENT HIF-1?? ACTIVATION IN GUT ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BACTERIA AND LIPOPOLYSACCHARIDE by Koury, Jadd, Deitch, Edwin A, Homma, Hiroshi, Abungu, Billy, Gangurde, Pranoti, Condon, Michael R, Lu, Qi, Xu, Da-Zhong, Feinman, Rena

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Abstract LB-237: In vitro and in vivo characterization of CPI-267203, a potent Inhibitor of bromodomain-containing proteins by Normant, Emmanuel, Cummings, Richard, Bellon, Steven, Bailey, Christopher, Albrecht, Brian, Hewitt, Michael, Pardo, Eneida, Campbell, Robert, Jayaram, Hari, Poy, Florence, Sandy, Peter, Gangurde, Pranoti

“…Abstract The transcription factor c-Myc regulates diverse biological processes including growth, proliferation, differentiation, quiescence, and senescence or…”
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Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy by Chang, Yong S., Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A., Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z., Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E., Horstick, James, Annis, D. Allen, Manning, Anthony M., Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T., Sawyer, Tomi K.

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Stapled [alpha]-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy by Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K

“…Stapled α-helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we report a potent and selective dual…”
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At play in the briar patch of epigenetics by Kiefer, Jim, Trojer, Patrick, Classon, Marie, Vinogradova, Maia, Gehling, Victor, Arora, Shilpi, Gustafson, Amy, Albrecht, Brian, Tindell, Charles, Williamson, Kaylyn, Wilson, Catherine, Busby, Jennifer, Liu, Yichin, Gangurde, Pranoti, Arnott, David, Buker, Shane, Cheung, Tommy, Lan, Fei, Jackson, Erica, Flynn, Megan, Cochran, Andrea, Maille, Tobias, Guler, Gulfem, Bailey, Christopher, Cummings, Richard, Pitti, Robert, Wongchenko, Matthew, Yang, Yibing, Lau, Ted, Costa, Mike, Harmange, Jean-Christophe, Settleman, Jeffrey

“…Abstract only…”
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Persistent HIF-1α activation in gut ischemia/reperfusion injury: Potential role of bacteria and lipopolysaccharide by KOURY, Jadd, DEITCH, Edwin A, HOMMA, Hiroshi, ABUNGU, Billy, GANGURDE, Pranoti, CONDON, Michael R, QI LU, XU, Da-Zhong, FEINMAN, Rena

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Stapled Peptides: Leveraging the BH3 α-Helix to Create a New Class of Drugs to Treat Hematological Malignancies by Kapeller, Rosana, Han, Jiawen, Sun, Kaiming, Gangurde, Pranoti, Kawahata, Nori, Iadanza, Matt, Guerlevais, Vincent, Horstick, Jim, Noehre, Justin, Annis, Allen, Licklider, Larry, Nash, Huw M., Kung, Andrew, Sawyer, Tomi K.

“…AILERON is developing a selective approach to restore programmed cell death in cancer cells by borrowing from nature the BH3 domain alpha-helical “keys” from…”
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A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells by Wen, Danyi, Nong, Yuhua, Morgan, Jennifer G, Gangurde, Pranoti, Bielecki, Andrew, Dasilva, Jennifer, Keaveney, Marie, Cheng, Hong, Fraser, Chris, Schopf, Lisa, Hepperle, Michael, Harriman, Geraldine, Jaffee, Bruce D, Ocain, Timothy D, Xu, Yajun

“…IkappaB kinase (IKK) beta is essential for inflammatory cytokine-induced activation of nuclear factor kappaB (NF-kappaB). NF-kappaB plays a pivotal role in the…”
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Persistent HIF-1alpha activation in gut ischemia/reperfusion injury: potential role of bacteria and lipopolysaccharide by Koury, Jadd, Deitch, Edwin A, Homma, Hiroshi, Abungu, Billy, Gangurde, Pranoti, Condon, Michael R, Lu, Qi, Xu, Da-Zhong, Feinman, Rena

“…In both animal models of hemorrhagic shock and clinical settings, shock-induced gut ischemia has been implicated in the development of the systemic…”
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IKKβ inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis by Schopf, Lisa, Savinainen, Anneli, Anderson, Karen, Kujawa, Julie, DuPont, Michelle, Silva, Matthew, Siebert, Elizabeth, Chandra, Sudeep, Morgan, Jennifer, Gangurde, Pranoti, Wen, Danyi, Lane, Joan, Xu, Yajun, Hepperle, Michael, Harriman, Geraldine, Ocain, Timothy, Jaffee, Bruce

“…Objective The IKK complex regulates NF‐κB activation, an important pathway implicated in the rheumatoid arthritis (RA) disease process. This study was…”
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IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis by Schopf, Lisa, Savinainen, Anneli, Anderson, Karen, Kujawa, Julie, DuPont, Michelle, Silva, Matthew, Siebert, Elizabeth, Chandra, Sudeep, Morgan, Jennifer, Gangurde, Pranoti, Wen, Danyi, Lane, Joan, Xu, Yajun, Hepperle, Michael, Harriman, Geraldine, Ocain, Timothy, Jaffee, Bruce

“…The IKK complex regulates NF-kappaB activation, an important pathway implicated in the rheumatoid arthritis (RA) disease process. This study was undertaken to…”
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