Search Results - "Ganguly, Sourik S."

Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1 by Sims, Jonathan T, Ganguly, Sourik S, Bennett, Holly, Friend, J Woodrow, Tepe, Jessica, Plattner, Rina

“…Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either…”
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The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis by Ganguly, Sourik S, Li, Xiaohong, Miranti, Cindy K

“…Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa deaths are due to osteoblastic bone metastases. What triggers PCa…”
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Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82 by Bergsma, Alexis, Ganguly, Sourik S, Wiegand, Mollie E, Dick, Daniel, Williams, Bart O, Miranti, Cindy K

“…We used a myeloid-specific Cre to conditionally delete CD82 in mouse osteoclasts and their precursors. In contrast to global loss of CD82 (gKO), conditional…”
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Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer by Nollet, Eric A., Cardo-Vila, Marina, Ganguly, Sourik S., Tran, Jack D., Schulz, Veronique V., Cress, Anne, Corey, Eva, Miranti, Cindy K.

“…The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease…”
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Notch3 promotes prostate cancer-induced bone lesion development via MMP-3 by Ganguly, Sourik S., Hostetter, Galen, Tang, Lin, Frank, Sander B., Saboda, Kathylynn, Mehra, Rohit, Wang, Lisha, Li, Xiaohong, Keller, Evan T., Miranti, Cindy K.

“…Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with…”
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Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis by Bergsma, Alexis, Ganguly, Sourik S., Dick, Daniel, Williams, Bart O., Miranti, Cindy K.

“…CD82 is a widely expressed member of the tetraspanin family of transmembrane proteins known to control cell signaling, adhesion, and migration. Tetraspanin…”
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Activation of abl family kinases in solid tumors by Ganguly, Sourik S, Plattner, Rina

“…Although c-Abl and Arg non-receptor tyrosine kinases are well known for driving leukemia development, their role in solid tumors has not been appreciated until…”
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c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer by Fiore, L S, Ganguly, S S, Sledziona, J, Cibull, M L, Wang, C, Richards, D L, Neltner, J M, Beach, C, McCorkle, J R, Kaetzel, D M, Plattner, R

“…Metastasis suppressors comprise a growing class of genes whose downregulation triggers metastatic progression. In contrast to tumor suppressors, metastasis…”
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Loss of Myeloid-Specific TGF-β Signaling Decreases CTHRC1 to Downregulate bFGF and the Development of H1993-Induced Osteolytic Bone Lesions by Ganguly, Sourik S, Daft, Paul G, Cao, Jingchen, Meng, Xiangqi, Zhong, Zhendong A, Vander Ark, Alexandra, Meadows, Austin, Madaj, Zach, Williams, Bart, Li, Xiaohong

“…The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a…”
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Androgen receptor-induced integrin [alpha]6[beta]1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer by Nollet, Eric A, Cardo-Vila, Marina, Ganguly, Sourik S, Tran, Jack D, Schulz, Veronique V, Cress, Anne, Corey, Eva

“…The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease…”
Get full text

Androgen Receptor-Induced Integrin α6β1 and Bnip3 Promotes Survival and Resistance to PI3K Inhibitors in Castration-Resistant Prostate Cancer by Nollet, Eric A., Cardo-Vila, Marina, Ganguly, Sourik S., Tran, Jack D., Schulz, Veronique V., Cress, Anne, Corey, Eva, Miranti, Cindy K.

“…The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration resistant disease…”
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c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression by Ganguly, S S, Fiore, L S, Sims, J T, Friend, J W, Srinivasan, D, Thacker, M A, Cibull, M L, Wang, C, Novak, M, Kaetzel, D M, Plattner, R

“…Despite 35 years of clinical trials, there is little improvement in 1-year survival rates for patients with metastatic melanoma, and the disease is essentially…”
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Imatinib Reverses Doxorubicin Resistance by Affecting Activation of STAT3-Dependent NF-[kappa]B and HSP27/p38/AKT Pathways and by Inhibiting ABCB1 by Sims, Jonathan T, Ganguly, Sourik S, Bennett, Holly, Friend, J. Woodrow, Tepe, Jessica, Plattner, Rina

“…Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either…”
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Abstract C51: c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion, proliferation, survival, and drive metastatic progression by Ganguly, Sourik S., Fiore, Leann S., Sims, Jonathan T., Friend, J Woodrow, Srinivasan, DivyaMani, Thacker, Matthew, Cibull, Michael L., Chi, Wang, Plattner, Rina

“…Abstract Despite 40 years of clinical trials, there has been little improvement in one-year survival rates for patients with metastatic melanoma, and the…”
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Molecular mechanisms by which c-Abl and Arg mediate melanoma invasion and metastasis by Ganguly, Sourik S

“…Metastasis is one of the main causes of death in cancer patients. Metastatic melanoma is a death sentence, as chemotherapeutic agents have a 5% success rate or…”
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