Search Results - "Gangopadhyay, Anu"

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages by Chu, Lan H., Indramohan, Mohanalaxmi, Ratsimandresy, Rojo A., Gangopadhyay, Anu, Morris, Emily P., Monack, Denise M., Dorfleutner, Andrea, Stehlik, Christian

“…Lipopolysaccharide (LPS) of Gram-negative bacteria can elicit a strong immune response. Although extracellular LPS is sensed by TLR4 at the cell surface and…”
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The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation by Ratsimandresy, Rojo A., Chu, Lan H., Khare, Sonal, de Almeida, Lucia, Gangopadhyay, Anu, Indramohan, Mohanalaxmi, Misharin, Alexander V., Greaves, David R., Perlman, Harris, Dorfleutner, Andrea, Stehlik, Christian

“…Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins…”
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Vaccination with human papillomavirus pseudovirus-encapsidated plasmids targeted to skin using microneedles by Kines, Rhonda C, Zarnitsyn, Vladimir, Johnson, Teresa R, Pang, Yuk-Ying S, Corbett, Kizzmekia S, Nicewonger, John D, Gangopadhyay, Anu, Chen, Man, Liu, Jie, Prausnitz, Mark R, Schiller, John T, Graham, Barney S

“…Human papilloma virus-like particles (HPV VLP) serve as the basis of the current licensed vaccines for HPV. We have previously shown that encapsidation of DNA…”
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Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD by Amarnath, Shoba, Flomerfelt, Francis A., Costanzo, Carliann M., Foley, Jason E., Mariotti, Jacopo, Konecki, Daniel M., Gangopadhyay, Anu, Eckhaus, Michael, Wong, Susan, Levine, Bruce L., June, Carl H., Fowler, Daniel H.

“…Murine T cells exposed to rapamycin maintain flexibility towards Th1/Tc1 differentiation, thereby indicating that rapamycin promotion of regulatory T cells…”
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NLRP3 licenses NLRP11 for inflammasome activation in human macrophages by Gangopadhyay, Anu, Devi, Savita, Tenguria, Shivendra, Carriere, Jessica, Nguyen, Huyen, Jäger, Elisabeth, Khatri, Hemisha, Chu, Lan H., Ratsimandresy, Rojo A., Dorfleutner, Andrea, Stehlik, Christian

“…Intracellular sensing of stress and danger signals initiates inflammatory innate immune responses by triggering inflammasome assembly, caspase-1 activation and…”
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An updated view on the structure and function of PYRIN domains by Chu, Lan Hoang, Gangopadhyay, Anu, Dorfleutner, Andrea, Stehlik, Christian

“…The PYRIN domain (PYD) is a protein–protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling…”
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The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses by Khare, Sonal, Ratsimandresy, Rojo A, de Almeida, Lúcia, Cuda, Carla M, Rellick, Stephanie L, Misharin, Alexander V, Wallin, Melissa C, Gangopadhyay, Anu, Forte, Eleonora, Gottwein, Eva, Perlman, Harris, Reed, John C, Greaves, David R, Dorfleutner, Andrea, Stehlik, Christian

“…Much is known about the activation of inflammasomes, but less is known about their negative regulation. Stehlik and colleagues demonstrate that the pyrin…”
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NLRP11 Is Essential for NLRP3 Inflammasome Activation by Gangopadhyay, Anu

“…Inflammasomes are intracellular multiprotein signaling complexes that link Pathogen Associated and Danger Associated Molecular Patterns (PAMPs and DAMPs) by…”
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Activation of Wingless Targets Requires Bipartite Recognition of DNA by TCF by Chang, Mikyung V., Chang, Jinhee L., Gangopadhyay, Anu, Shearer, Andrew, Cadigan, Ken M.

“…Specific recognition of DNA by transcription factors is essential for precise gene regulation. In Wingless (Wg) signaling in Drosophila, target gene regulation…”
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Abstract 5544: IL10/IL2 surrogate cytokine agonists by Ramadass, Mahalakshmi, Vivona, Sandro, Rokkam, Deepti, Greb, Heiko, Gangopadhyay, Anu, Riener, Romina, Malefyt, Rene de Waal, Lupardus, Patrick, Oft, Martin, Kastelein, Robert

“…Abstract Introduction: IL10 is a pleiotropic cytokine that is secreted as a homodimer and initiates signaling on various cell types by engaging two copies of a…”
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POP3 is a novel inhibitor of ALR inflammasomes and controls host defense to DNA virus infections (INM6P.411) by Stehlik, Christian, Khare, Sonal, Ratsimandresy, Rojo, de Almeida, Lúcia, Cuda, Carla, Rellick, Stephanie, Misharin, Alexander, Wallin, Melissa, Gangopadhyay, Anu, Forte, Eleonora, Gottwein, Eva, Perlman, Harris, Reed, John, Greaves, David, Dorfleutner, Andrea

“…Abstract The innate immune system responds to infections and tissue damage by activating cytosolic sensory complexes called inflammasomes. Cytosolic DNA is…”
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The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections by Khare, Sonal, Ratsimandresy, Rojo A., de Almeida, Lúcia, Cuda, Carla M., Rellick, Stephanie L., Misharin, Alexander V., Wallin, Melissa C., Gangopadhyay, Anu, Forte, Eleonora, Gottwein, Eva, Perlman, Harris, Reed, John C., Greaves, David R., Dorfleutner, Andrea, Stehlik, Christian

“…The innate immune system responds to infections and tissue damage by activating cytosolic sensory complexes called inflammasomes. Cytosolic DNA is sensed by…”
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T-Rapa Cell Clinical Products Contain a Balance of Minimally Differentiated Th2/Th1 Effector Cells Depleted of Treg Cells by Mossoba, Miriam E., Mariotti, Jacopo, Yan, Xiao-Yi, Gangopadhyay, Anu, Winterton, Mathew, Sabatino, Marianna, Khuu, Hanh, Fellowes, Vicki, Hakim, Frances T., Stroncek, David, Leitman, Susan, Levine, Bruce L, June, Carl H., Fowler, Daniel H

“…Abstract 352 Ex-vivo expansion of murine donor CD4+ T cells using co-stimulation, IL-4, and rapamycin generated a T cell population (T-rapa cells) that…”
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Rapamycin-Induced Autophagy Generates Anti-Apoptotic Th1/Tc1 Cells That Mediate Increased Xenogeneic Gvhd by Amarnath, Shoba, Costanzo, Carliann M, Foley, Jason, Mariotti, Jacopo, Konecki, Daniel M, Gangopadhyay, ANu, Eckhaus, Michael, Wong, Susan, Levine, Bruce, June, Carl H., Fowler, Daniel H.

“…Abstract 2456 Poster Board II-433 Murine T cells exposed to rapamycin maintain flexibility towards Th1/Tc1 differentiation; the degree to which rapamycin might…”
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Vaccination with Human Papillomavirus Pseudovirus-Encapsidated Plasmids Targeted to Skin Using Microneedles: e0120797 by Kines, Rhonda C, Zarnitsyn, Vladimir, Johnson, Teresa R, Pang, Yuk-Ying S, Corbett, Kizzmekia S, Nicewonger, John D, Gangopadhyay, Anu, Chen, Man, Liu, Jie, Prausnitz, Mark R

“…Human papilloma virus-like particles (HPV VLP) serve as the basis of the current licensed vaccines for HPV. We have previously shown that encapsidation of DNA…”
Get full text

The oxidized phospholipid oxPAPC ameliorates septic shock by targeting the non-canonical inflammasome in macrophages by CHU, LAN H., Indramohan, Mohanalaxmi, Ratsimandresy, Rojo A., Gangopadhyay, Ạnu, Morris, Emily P., Monack, Denise M., Dorfleutner, Andrea, Stehlik, Christian

“…Abstract Inflammasomes are signaling complexes that link the recognition of pathogen and danger associated molecular patterns (PAMPs and DAMPs) by cytosolic…”
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