Search Results - "Ganghammer, Sylvia"
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Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors
Published in Haematologica (Roma) (01-03-2016)Get full text
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Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells
Published in Blood (03-04-2014)“…Signals from the tumor microenvironment promote the migration, survival, and proliferation of chronic lymphocytic leukemia (CLL) cells. Rho GTPases control…”
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ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia
Published in Cancer research (Chicago, Ill.) (15-04-2016)“…The proliferation of chronic lymphocytic leukemia (CLL) cells requires communication with the lymphoid organ microenvironment. Integrin-linked kinase (ILK) is…”
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CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21
Published in Oncotarget (20-05-2015)“…Homing to distinct lymphoid organs enables chronic lymphocytic leukemia (CLL) cells to receive pro-survival and proliferative signals. Cytogenetic aberrations…”
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88 : CXCR3 modulates CXCL12-mediated cellular responses in chronic lymphocytic leukemia
Published in Cytokine (Philadelphia, Pa.) (01-09-2013)“…Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B lymphocytes that accumulate in blood, bone marrow, and secondary lymphoid organs. Signals…”
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The Spiegelmer® Nox-A12 Abrogates Homing Of Human CLL Cells To Bone Marrow and Mobilizes Murine CLL Cells In The Eμ-TCL1 Transgenic Mouse Model Of CLL
Published in Blood (15-11-2013)“…▪ NOX-A12 is a novel mirror-image oligonucleotide (Spiegelmer®) that specifically antagonizes the chemokine stromal cell-derived factor 1 (SDF-1, CXCL12)…”
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Chronic Lymphocytic Leukemia Cells With Trisomy 12 Home To The Bone Marrow In a CXCR4-Independent Manner and Are Prone To Proliferate In Vitro
Published in Blood (15-11-2013)“…Trisomy 12 (tri12) is a frequent chromosomal aberration in chronic lymphocytic leukemia (CLL) associated with atypical cell morphology, high in vivo tumor…”
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