Search Results - "Gangalum, Rajendra K."

Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression by Gangalum, Rajendra K, Kim, Dongjae, Kashyap, Raj K, Mangul, Serghei, Zhou, Xinkai, Elashoff, David, Bhat, Suraj P

“…The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells,…”
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Purification of BAC DNA for high-efficiency transgenesis by Gangalum, Rajendra K, Jing, Zhe, Nagaoka, Yoshiko, Jiang, Meisheng, Bhat, Suraj P

“…An unresolved bottleneck in bacterial artificial chromosome (BAC) transgenesis is low efficiency generation of founder mice because of suboptimal quality of…”
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Inhibition of the Expression of the Small Heat Shock Protein αB-Crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture by Gangalum, Rajendra K., Bhat, Ankur M., Kohan, Sirus A., Bhat, Suraj P.

“…Exosomes carry cell type-specific molecular cargo to extracellular destinations and therefore act as lateral vectors of intercellular communication and…”
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αB-Crystallin Is Found in Detergent-resistant Membrane Microdomains and Is Secreted via Exosomes from Human Retinal Pigment Epithelial Cells by Gangalum, Rajendra K., Atanasov, Ivo C., Zhou, Z. Hong, Bhat, Suraj P.

“…αB-crystallin (αB) is known as an intracellular Golgi membrane-associated small heat shock protein. Elevated levels of this protein have been linked with a…”
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Transcriptional profiling of single fiber cells in a transgenic paradigm of an inherited childhood cataract reveals absence of molecular heterogeneity by Bhat, Suraj P., Gangalum, Rajendra K., Kim, Dongjae, Mangul, Serghei, Kashyap, Raj K., Zhou, Xinkai, Elashoff, David

“…Our recent single-cell transcriptomic analysis has demonstrated that heterogeneous transcriptional activity attends molecular transition from the nascent to…”
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Secretion of αB-Crystallin via exosomes: New clues to the function of human retinal pigment epithelium by Bhat, Suraj P., Gangalum, Rajendra K.

“…αB-crystallin (αB) is an archetypical small heat shock protein whose physiological function is not clearly defined. The interest in this protein arises from…”
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αA-Crystallin and αB-Crystallin Reside in Separate Subcellular Compartments in the Developing Ocular Lens by Gangalum, Rajendra K., Horwitz, Joseph, Kohan, Sirus A., Bhat, Suraj P.

“…αA-Crystallin (αA) and αB-crystallin (αB), the two prominent members of the small heat shock family of proteins are considered to be two subunits of one…”
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HSF4 Mutation p.Arg116His Found in Age-Related Cataracts and in Normal Populations Produces Childhood Lamellar Cataract in Transgenic Mice by Jing, Zhe, Gangalum, Rajendra K., Bhat, Ankur M., Nagaoka, Yoshiko, Jiang, Meisheng, Bhat, Suraj P.

“…ABSTRACT The p.Arg116His mutation in the heat shock transcription factor‐4 (HSF4) has been associated with age‐related cataracts, but it is also seen in 2% of…”
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Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice by Gangalum, Rajendra K, Jing, Zhe, Bhat, Ankur M, Lee, Josh, Nagaoka, Yoshiko, Deng, Sophie X, Jiang, Meisheng, Bhat, Suraj P

“…The clinical management of cataracts in infancy involves surgical removal of the lens to ensure transmission of light to the retina, which is essential for…”
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αB-crystallin: A Golgi-Associated Membrane Protein in the Developing Ocular Lens by GANGALUM, Rajendra K, BHAT, Suraj P

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Analysis of the role of ZEB1 in the pathogenesis of posterior polymorphous corneal dystrophy by Yellore, Vivek S, Rayner, Sylvia A, Nguyen, Catherine K, Gangalum, Rajendra K, Jing, Zhe, Bhat, Suraj P, Aldave, Anthony J

“…To determine how nonsense mutations in the transcription factor ZEB1 lead to the development of posterior polymorphous corneal dystrophy type 3 (PPCD3)…”
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Cell-type-dependent access of HSF1 and HSF4 to αB-crystallin promoter during heat shock by Jing, Zhe, Gangalum, Rajendra K., Lee, Josh Z., Mock, Dennis, Bhat, Suraj P.

“…Epithelial cells and fibroblasts both express heat shock transcription factors, HSF1 and HSF4, yet they respond to heat shock differentially. For example,…”
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A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin by Jing, Zhe, Gangalum, Rajendra K, Mock, Dennis C, Bhat, Suraj P

“…Deciphering of the information content of eukaryotic promoters has remained confined to universal landmarks and conserved sequence elements such as enhancers…”
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Erratum to: Cell-type-dependent access of HSF1 and HSF4 to αB-crystallin promoter during heat shock by Jing, Zhe, Gangalum, Rajendra K., Lee, Josh Z., Mock, Dennis, Bhat, Suraj P.

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Erratum to: Cell-type-dependent access of HSF1 and HSF4 to [alpha]B-crystallin promoter during heat shock by Jing, Zhe, Gangalum, Rajendra K, Lee, Josh Z, Mock, Dennis, Bhat, Suraj P

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Cell-type-dependent access of HSF1 and HSF4 to [alpha]B-crystallin promoter during heat shock by Jing, Zhe, Gangalum, Rajendra K, Lee, Josh Z, Mock, Dennis, Bhat, Suraj P

“…Epithelial cells and fibroblasts both express heat shock transcription factors, HSF1 and HSF4, yet they respond to heat shock differentially. For example,…”
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A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene AlphaB-crystallin by Jing, Zhe, Gangalum, Rajendra K, Mock, Dennis C, Bhat, Suraj P

“…Background Deciphering of the information content of eukaryotic promoters has remained confined to universal landmarks and conserved sequence elements such as…”
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Small Heat Shock Protein αB-Crystallin Is Part of Cell Cycle-dependent Golgi Reorganization by Gangalum, Rajendra K., Schibler, Matthew J., Bhat, Suraj P.

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AlphaB-crystallin: a Golgi-associated membrane protein in the developing ocular lens by Gangalum, Rajendra K, Bhat, Suraj P

“…All crystallins have non-crystallin catalytic functions. Because catalytic functions do not require large concentrations of protein, as are seen in the lens,…”
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Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization by Gangalum, Rajendra K, Schibler, Matthew J, Bhat, Suraj P

“…AlphaB-crystallin is a developmentally regulated small heat shock protein known for its binding to a variety of denatured polypeptides and suppression of…”
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