Search Results - "Ganga Reddy, V"
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Synthesis of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents
Published in European journal of medicinal chemistry (19-07-2016)“…A series of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives were synthesized and characterized by 1H and 13C NMR, ESI-MS and…”
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Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors
Published in European journal of medicinal chemistry (21-10-2016)“…A series of new (N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives (8–35) were designed, synthesized and evaluated…”
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Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents
Published in Organic & biomolecular chemistry (01-01-2015)“…A series of pyrazolo-triazole hybrids were designed and synthesized by combining the 1,3-diphenyl pyrazole and triazole scaffolds to obtain…”
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Synthesis of Gold(I) Complexes Containing Cinnamide: In Vitro Evaluation of Anticancer Activity in 2D and 3D Spheroidal Models of Melanoma and In Vivo Angiogenesis
Published in Inorganic chemistry (06-05-2019)“…A series of alkynylgold(I) phosphine complexes containing methoxy-substituted cinnamide moieties (3a–3c and 4a–4c) have been synthesized and characterized…”
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Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors
Published in Bioorganic & medicinal chemistry letters (01-08-2014)“…A series of novel 4-aza-2,3-dihydropyridophenanthrolines 12(a-t) were synthesized by a one-step three component condensation of 1,10-phenanthroline amine,…”
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Design, synthesis and biological evaluation of 1,3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis inducing agents
Published in European journal of medicinal chemistry (28-08-2015)“…A series of forty different pyrazole containing benzimidazole hybrids (6–45) have been designed, synthesized and evaluated for their potential…”
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An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS
Published in Biomedical chromatography (01-10-2016)“…The aim of the present study was to evaluate the contribution of metabolites to drug–drug interaction and drug–herb interaction using the inhibition of CYP2D6…”
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4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer
Published in European journal of medicinal chemistry (20-01-2018)“…Topoisomerases (topo-I and topo-II) have occupied a significant role in DNA replication, transcription, and are a promising set of antitumor targets. In the…”
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Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis
Published in European journal of medicinal chemistry (20-01-2018)“…A series of 1, 4-dihydroindeno-[1,2-c] pyrazole linked oxindole conjugates have been synthesized by using Knoevenagel condensation method and further evaluated…”
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Synthesis of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates as microtubule targeting and apoptosis inducing agents
Published in Bioorganic chemistry (01-02-2018)“…[Display omitted] •A series of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates were synthesised and evaluated for antiproliferative activity.•Conjugates 5d…”
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Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors
Published in Bioorganic & medicinal chemistry (01-10-2014)“…A series of new podophyllotoxin derivatives containing structural modifications at C-7, C-8, and C-9 were synthesized and evaluated for their cytotoxic…”
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Metal‐Free Aerobic Oxidative C−C Bond Cleavage between the Carbonyl Carbon and the α‐Carbon of α‐Azido Ketones: A Novel Synthesis of N‐Alkylated Benzamides
Published in Asian journal of organic chemistry (01-10-2017)“…An unprecedented metal‐free approach has been achieved for the synthesis of N‐alkylated benzamides from phenacyl azides by oxidative cleavage of a C−C bond and…”
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Metal-Free Aerobic Oxidative C-C Bond Cleavage between the Carbonyl Carbon and the [alpha]-Carbon of [alpha]-Azido Ketones: A Novel Synthesis of N-Alkylated Benzamides
Published in Asian journal of organic chemistry (01-10-2017)“…An unprecedented metal-free approach has been achieved for the synthesis of N-alkylated benzamides from phenacyl azides by oxidative cleavage of a C-C bond and…”
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Annulation of 4‐Hydroxypyrones and α‐Keto Vinyl Azides; A Regiospecific Approach towards the Synthesis of Furo[3, 2‐c]Pyrone Scaffolds under Catalyst Free Condition
Published in ChemistrySelect (Weinheim) (11-09-2017)“…A mild and efficient strategy for the construction of furo[3, 2‐c]pyrones via an annulation of α‐keto vinyl azides and 4‐hydroxypyrones under catalyst free…”
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