Search Results - "Ganey, P E"

Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis by Roberts, Ruth A., Ganey, Patricia E., Ju, Cynthia, Kamendulis, Lisa M., Rusyn, Ivan, Klaunig, James E.

“…Kupffer cells are resident macrophages of the liver and play an important role in its normal physiology and homeostasis as well as participating in the acute…”
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Is Exposure to Bacterial Endotoxin a Determinant of Susceptibility to Intoxication from Xenobiotic Agents? by Roth, Robert A., Harkema, Jack R., Pestka, James P., Ganey, Patricia E.

“…Why certain individuals are more susceptible than others to harmful effects of chemical exposure remains incompletely understood. One understudied but…”
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Mechanisms of Inflammatory Liver Injury: Adhesion Molecules and Cytotoxicity of Neutrophils by Jaeschke, Hartmut, Smith, C.Wayne, Clemens, Mark G., Ganey, Patricia E., Roth, Robert A.

“…During recent years, increasing experimental evidence has suggested that hepatic nonparenchymal cells, in particular Kupffer cells and neutrophils, can…”
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Synergistic Hepatotoxicity from Coexposure to Bacterial Endotoxin and the Pyrrolizidine Alkaloid Monocrotaline by Yee, Steven B., Kinser, Shawn, Hill, Dwayne A., Barton, C.Charles, Hotchkiss, Jon A., Harkema, Jack R., Ganey, Patricia E., Roth, Robert A.

“…Individuals are commonly exposed to bacterial endotoxin (lipopolysaccharide [LPS]) through gram-negative bacterial infection and from its translocation from…”
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Neutrophil activation by polychlorinated biphenyls : Structure-activity relationship by BROWN, A. P, OLIVERO-VERBEL, J, HOLDAN, W. L, GANEY, P. E

“…Polychlorinated biphenyls (PCBs) rapidly stimulate polymorphonuclear leukocytes (neutrophils) in vitro to produce superoxide anion (O2-). This response results…”
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The Coagulation System Contributes to Synergistic Liver Injury from Exposure to Monocrotaline and Bacterial Lipopolysaccharide by Yee, Steven B., Harkema, Jack R., Ganey, Patricia E., Roth, Robert A.

“…Coexposure to a noninjurious dose of bacterial lipopolysaccharide (LPS; 7.4 × 106 EU/kg) and a nontoxic dose of the food-borne toxin monocrotaline (MCT; 100…”
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Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity by Narayanan, P. K., Carter, W. O., Ganey, P. E., Roth, R. A., Voytik‐Harbin, S. L., Robinson, J. P.

“…We report evidence of a novel mechanism by which polychlorinated biphenyls might act as potent inducers of inflammation. Aroclor 1242 (A1242), a…”
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Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes by Ho, John S., Buchweitz, John P., Roth, Robert A., Ganey, Patricia E.

“…Activated polymorphonuclear neutrophils (PMNs) have been shown to be cytotoxic to rat hepatic parenchymal cells in vitro. This cytotoxicity could be observed…”
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Activated neutrophils from rat injured isolated hepatocytes by Ganey, P E, Bailie, M B, VanCise, S, Colligan, M E, Madhukar, B V, Robinson, J P, Roth, R A

“…Activated neutrophils (PMNs) release cytotoxic agents that can damage surrounding tissue. These studies were performed to determine whether activated PMNs from…”
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Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity by SNEED, R. A, BUCHWEITZ, J. P, JEAN, P. A, GANEY, P. E

“…Small amounts of exogenous lipopolysaccharide (LPS) (10 ng/kg-100 microg/kg) enhance the hepatotoxicity of allyl alcohol in male Sprague-Dawley rats. This…”
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Bacterial Endotoxin Enhances the Hepatotoxicity of Allyl Alcohol by Sneed, Rosie A., Grimes, Sheila D., Schultze, A.Eric, Brown, Alan P., Ganey, Patricia E.

“…Lipopolysaccharide (LPS), or bacterial endotoxin, causes liver damage at relatively large doses in rats. Smaller doses, however, may influence the response to…”
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The Role of Neutrophils in Producing Hepatocellular Dysfunction during the Hyperdynamic Stage of Sepsis in Rats by Molnar, Robert G., Wang, Ping, Ayala, Alfred, Ganey, Patricia E., Roth, Robert A., Chaudry, Irshad H.

“…Although studies have shown that hepatocellular function is depressed during the early, hyperdynamic stage of sepsis, the mechanism responsible for this…”
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Neutrophil Degranulation and Superoxide Production Induced by Polychlorinated Biphenyls Are Calcium Dependent by Brown, A.P., Ganey, P.E.

“…2,2′,4,4′-Tetrachlorobiphenyl (TCB), a polychlorinated biphenyl (PCB), alters neutrophil functions in vitro by unknown mechanisms. The role of calcium in…”
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Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils by Olivero-Verbel, Jesus, Ganey, Patricia Elaine

“…It has been known that polychlorinated biphenyl (PCB) mixtures and individual congeners produce degranulation of rat neutrophils. Structure–activity…”
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Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls by Tithof, Patricia K., Watts, Stephanie, Ganey, Patricia E.

“…Neutrophils produce Superoxide anion (O 2 −) when exposed in vitro to Aroclor 1242, a mixture of polychlorinated biphenyls (PCBs). The mechanism for this…”
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Altered Biologic Activities of Commercial Polychlorinated Biphenyl Mixtures after Microbial Reductive Dechlorination by Mousa, Mahmoud A., Ganey, Patricia E., Quensen, John F., Madhukar, Burra V., Karen Chou, Giesy, John P., Fischer, Lawrence J., Boyd, Stephen A.

“…The reductive dechlorination of polychlorinated biphenyls (PCBs) by anaerobic bacteria has recently been established as an important environmental fate of…”
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Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents by Ganey, Patricia E, Roth, Robert A

“…Sensitivity to the toxic effects of xenobiotic agents is influenced by a number of factors. Recent evidence derived from studies using experimental animals…”
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Alteration by flutamide of neutrophil response to stimulation: Implications for tissue injury by Srinivasan, Radhika, Buchweitz, John P., Ganey, Patricia E.

“…When activated, inflammatory cells such as polymorphonuclear leukocytes (PMNs) can damage isolated hepatocytes in vitro. These studies were performed to…”
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Role of Protein Phosphorylation in Activation of Phospholipase A2 by the Polychlorinated Biphenyl Mixture Aroclor 1242 by Olivero, Jesus, Ganey, Patricia E.

“…Polychlorinated biphenyls (PCBs) activate neutrophils to induce degranulation and undergo superoxide production through a mechanism that involves stimulation…”
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Oxygen-dependent hepatotoxicity due to doxorubicin: role of reducing equivalent supply in perfused rat liver by Ganey, P E, Kauffman, F C, Thurman, R G

“…Doxorubicin is an important anticancer drug that undergoes redox cycling leading to the production of oxygen radicals; however, its clinical use is limited by…”
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