Search Results - "Ganeshapillai, Dharshini"

Structure-Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495) by Woo, L. W. Lawrence, Ganeshapillai, Dharshini, Thomas, Mark P., Sutcliffe, Oliver B., Malini, Bindu, Mahon, Mary F., Purohit, Atul, Potter, Barry V. L.

“…Structure–activity relationship studies were conducted on Irosustat (STX64, BN83495), the first steroid sulfatase (STS) inhibitor to enter diverse clinical…”
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C‑3- and C‑4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors by Ganeshapillai, Dharshini, Woo, L. W. Lawrence, Thomas, Mark P, Purohit, Atul, Potter, Barry V. L

“…Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in…”
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Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 by Su, Xiangdong, Vicker, Nigel, Ganeshapillai, Dharshini, Smith, Andrew, Purohit, Atul, Reed, Michael J., Potter, Barry V.L.

“…Selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) have considerable potential as treatments for metabolic diseases, such as diabetes…”
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Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 by Vicker, Nigel, Su, Xiangdong, Ganeshapillai, Dharshini, Smith, Andrew, Purohit, Atul, Reed, Michael J., Potter, Barry V.L.

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates glucocorticoid action at the pre-receptor stage by converting cortisone to cortisol. 11β-HSD1 is…”
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Cover Picture: Structure-Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495) (ChemMedChem 11/2011) by Woo, L. W. Lawrence, Ganeshapillai, Dharshini, Thomas, Mark P., Sutcliffe, Oliver B., Malini, Bindu, Mahon, Mary F., Purohit, Atul, Potter, Barry V. L.

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Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases by Su, Xiangdong, Lawrence, Harshani, Ganeshapillai, Dharshini, Cruttenden, Adrian, Purohit, Atul, Reed, Michael J, Vicker, Nigel, Potter, Barry V.L

“…The discovery of novel potent selective inhibitors of 11β-HSD2 is described. Extensive structural modifications to the 18β-glycyrrhetinic acid template are…”
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Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 by Vicker, Nigel, Su, Xiangdong, Ganeshapillai, Dharshini, Smith, Andrew, Purohit, Atul, Reed, Michael J, Potter, Barry V L

“…11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regulates glucocorticoid action at the pre-receptor stage by converting cortisone to cortisol…”
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Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 by Su, Xiangdong, Vicker, Nigel, Ganeshapillai, Dharshini, Smith, Andrew, Purohit, Atul, Reed, Michael J, Potter, Barry V L

“…Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) have considerable potential as treatments for metabolic diseases, such as…”
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Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases by Su, Xiangdong, Lawrence, Harshani, Ganeshapillai, Dharshini, Cruttenden, Adrian, Purohit, Atul, Reed, Michael J, Vicker, Nigel, Potter, Barry V L

“…Extensive structural modifications to the 18beta-glycyrrhetinic acid template are described and their effects on the SAR of the 11beta-hydroxysteroid…”
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The synthesis of novel anticancer agents with therapeutic potential by Ganeshapillai, Dharshini

“…Inhibition of steroid sulphatase activity is an important target for the development of new drugs for oncology and immunology. In this work, synthetic…”
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Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships by Wood, L, Leese, M R, Leblond, B, Woo, L W, Ganeshapillai, D, Purohit, A, Reed, M J, Potter, B V, Packham, G

“…Superoxide dismutases catalyse the dismutation of highly reactive superoxide ions to produce hydrogen peroxide and several lines of evidence suggest that these…”
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