Search Results - "Ganesh, Aravind"

Thrombectomy for Acute Ischemic Stroke: Recent Insights and Future Directions by Ganesh, Aravind, Goyal, Mayank

“…Purpose of Review Mechanical thrombectomy has become the standard of care for acute ischemic stroke with proximal large vessel occlusions (LVO). This article…”
Get full text

Sex and Gender Differences in Stroke and Their Practical Implications in Acute Care by Ospel, Johanna, Singh, Nishita, Ganesh, Aravind, Goyal, Mayank

“…There are several controversies regarding the role of sex and gender in the pathophysiology and management of acute stroke. Assessing the role of sex, i.e.,…”
Get full text

Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19 era by Ganesh, Aravind, Ospel, Johanna M., Kromm, Julie, Goyal, Mayank

Get full text

Confounding by Pre-Morbid Functional Status in Studies of Apparent Sex Differences in Severity and Outcome of Stroke by Renoux, Christel, Coulombe, Janie, Li, Linxin, Ganesh, Aravind, Silver, Louise, Rothwell, Peter M

“…Several studies have reported unexplained worse outcomes after stroke in women but none included the full spectrum of symptomatic ischemic cerebrovascular…”
Get full text

Stroke metrics during the first year of the COVID-19 pandemic, a tale of two comprehensive stroke centers by de Oliveira, Lara Carvalho, Ponciano, Ana, Kashani, Nima, Guarda, Suzete N. F., Hill, Michael D., Smith, Eric E., Stang, Jillian M., Viswanathan, Anand, Turner, Ashby C., Ganesh, Aravind

“…Although a decrease in stroke admissions during the SARS-CoV-2 pandemic has been observed, detailed analyses of the evolution of stroke metrics during the…”
Get full text

Time Course of Evolution of Disability and Cause-Specific Mortality After Ischemic Stroke: Implications for Trial Design by Ganesh, Aravind, Luengo-Fernandez, Ramon, Wharton, Rose M, Gutnikov, Sergei A, Silver, Louise E, Mehta, Ziyah, Rothwell, Peter M

“…Outcome in stroke trials is often based on a 3-month modified Rankin scale (mRS). How 3-month mRS relates to longer-term outcomes will depend on late recovery,…”
Get full text

Intravenous Thrombolysis in an Endovascular Treatment–Dominant Era: What Does the Future Hold? by Singh, Nishita, Kim, Beom Joom, Ganesh, Aravind, Menon, Bijoy

“…The definitive target of acute ischemic stroke is rapid and effective reperfusion. This is vastly conditional on rapid recognition of symptoms and efficient…”
Get full text

Quality of life, respiratory symptoms, and health care utilization 1 year following outpatient management of COVID-19: a prospective cohort study by Lim, Rachel K., Rosentreter, Ryan, Chen, Yushi, Mehta, Rahul, McLeod, Graham, Wan, Miranda, Krett, Jonathan D., Mahjoub, Yasamin, Lee, Angela, Schwartz, Ilan, Metz, Luanne, Richer, Lawrence, Smith, Eric, Hill, Michael D., Ganesh, Aravind

“…The long-term impact of COVID-19 among those with mild infections is not well characterized. Among 81 adults who completed online assessments at 3- and…”
Get full text

Integrating expert knowledge for dementia risk prediction in individuals with mild cognitive impairment (MCI): a study protocol by Wang, Meng, Smith, Eric E, Forkert, Nils Daniel, Chekouo, Thierry, Ismail, Zahinoor, Ganesh, Aravind, Sajobi, Tolulope

“…IntroductionTo date, there is no broadly accepted dementia risk score for use in individuals with mild cognitive impairment (MCI), partly because there are few…”
Get full text

Clinical impact of EVT with failed reperfusion in patients with acute ischemic stroke: results from the ESCAPE and ESCAPE-NA1 trials by Ospel, Johanna M., Hill, Michael D., Demchuk, Andrew, Menon, Bijoy K., Thornton, John, Rempel, Jeremy, Almekhlafi, Mohammed A., Ganesh, Aravind, Kappelhof, Manon, Singh, Nishita, Cimflova, Petra, Kashani, Nima, Bala, Fouzi, Kim, Beom Joon, McTaggart, Ryan, Poppe, Alexandre, Nogueira, Raul G., Tymianski, Michael, Goyal, Mayank

“…Background and purpose Endovascular treatment (EVT) is a powerful treatment for large vessel occlusion (LVO) stroke if reperfusion can be achieved, while in…”
Get full text

A Vaping Risks Education Program for School Students: Evaluation of the SOLVE Mystery Toolkit by Hollis, Asha, Downey, Emily, Standing, Shaelene, Leahy, Janet, Ebbert, Kirsten, Ganesh, Aravind

“…One in three grade 7 to 12 students in Canada report trying vaping or e-cigarettes. Despite consequences like nicotine addiction, impaired brain development,…”
Get full text

Weights for ordinal analyses of the modified Rankin Scale in stroke trials: A population-based cohort study by Ganesh, Aravind, Luengo-Fernandez, Ramon, Pendlebury, Sarah T., Rothwell, Peter M.

“…Ordinal/shift analyses of ordered measures like the modified Rankin Scale(mRS) are underused as primary trial outcomes for neurological disorders – despite…”
Get full text

Replacing Alteplase with Tenecteplase: Is the Time Ripe? by Singh, Nishita, Menon, Bijoy K, Dmytriw, Adam A, Regenhardt, Robert W, Hirsch, Joshua A, Ganesh, Aravind

“…Thrombolysis for acute ischemic stroke has predominantly been with alteplase for over a quarter of a century. In recent years, with trials showing evidence of…”
Get full text

Perceived importance of silent cerebral ischemia following endovascular procedures by McDonough, Rosalie V., Ganesh, Aravind, Ospel, Johanna M., Kappelhof, Manon, Almekhlafi, Mohammed, Goyal, Mayank

“…The clinical significance of iatrogenic diffusion-weighted imaging lesions following endovascular procedures is currently not well understood, partly because…”
Get full text

Platelet glycoprotein VI inhibition: a promising therapeutic avenue in acute ischaemic stroke by Ganesh, Aravind

“…Glenzocimab, a fully humanised antibody fragment, inhibits glycoprotein VI function, resulting in reduced infarct volumes and less reperfusion injury in murine…”
Get full text

Trial of remote ischaemic preconditioning in vascular cognitive impairment (TRIC-VCI): protocol by Ganesh, Aravind, Barber, Philip, Black, Sandra E, Corbett, Dale, Field, Thalia S, Frayne, Richard, Hachinski, Vladimir, Ismail, Zahinoor, Mai, Lauren M, McCreary, Cheryl R, Sahlas, Demetrios, Sharma, Mukul, Swartz, Richard H, Smith, Eric E

“…IntroductionCerebral small vessel disease (cSVD) accounts for 20%–25% of strokes and is the most common cause of vascular cognitive impairment (VCI). In an…”
Get full text

From Three-Months to Five-Years: Sustaining Long-Term Benefits of Endovascular Therapy for Ischemic Stroke by Ganesh, Aravind, Ospel, Johanna Maria, Marko, Martha, van Zwam, Wim H., Roos, Yvo B. W. E. M., Majoie, Charles B. L. M., Goyal, Mayank

“…Background and Purpose: During the months and years post-stroke, treatment benefits from endovascular therapy (EVT) may be magnified by disability-related…”
Get full text

The relationship of small vessel disease burden on cerebral and regional brain atrophy rates and cognitive performance over one year of follow-up after transient ischemic attack by Reaume, Noaah, Reid, Meaghan, Tadros, George S, Chacinski, Dorothy, Denroche, Britney, Aftab, Arooj, Wu, Pauline, Gupta Sah, Rani, Wang, Meng, Smith, Eric E, Frayne, Richard, Coutts, Shelagh B, Sajobi, Tolulope, Longman, Stewart, Ganesh, Aravind, Barber, Philip A

“…Stroke, even when minor, increases the risk of dementia. We aimed to determine whether patients with transient ischaemic attack (TIA) exhibit higher rates of…”
Get full text

Association of White Matter Disease With Functional Recovery and 90‐Day Outcome After EVT: Beyond Chronological Age by Benali, Faysal, Fladt, Joachim, Jaroenngarmsamer, Tanaporn, Bala, Fouzi, Singh, Nishita, Alhabli, Ibrahim, Ospel, Johanna, Tymianski, Michael, Hill, Michael D., Goyal, Mayank, Ganesh, Aravind

“…Background Patients with white matter disease (WMD) – a key marker of cerebral small vessel disease – may have less brain reserve to cope with ischemic injury…”
Get full text

How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes? by Ospel, Johanna M, Rinkel, Leon, Ganesh, Aravind, Demchuk, Andrew, Heran, Manraj, Sauvageau, Eric, Joshi, Manish, Haussen, Diogo, Jayaraman, Mahesh, Coutts, Shelagh, Yu, Amy, Puetz, Volker, Iancu, Dana, Bang, Oh Young, Tarpley, Jason, Holmin, Staffan, Kelly, Michael, Tymianski, Michael, Hill, Michael, Goyal, Mayank

“…Infarct volume and other imaging markers are increasingly used as surrogate measures for clinical outcome in acute ischemic stroke research, but how…”
Get full text