Search Results - "Gane, P J"

Microbial Relatives of the Seed Storage Proteins of Higher Plants: Conservation of Structure and Diversification of Function during Evolution of the Cupin Superfamily by DUNWELL, J. M, KHURI, S, GANE, P. J

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A molecular model for the redox potential difference between thioredoxin and DsbA, based on electrostatics calculations by Gane, P.J., Freedman, R.B., Warwicker, J.

“…The disulphide active sites of thioredoxin and DsbA are known to possess a high degree of structural homology. However, DsbA is a much stronger oxidant than…”
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Recent advances in structure-based rational drug design by Gane, Paul J, Dean, Philip M

“…Two approaches to structure-based drug design, that is, the docking of known compounds into a target protein and molecular assembly in situ, are seen to be…”
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Calculation of Cys 30 ΔpKa's and oxidising power for DsbA mutants by Warwicker, J., Gane, P.J.

“…DsbA possesses a redox active disulphide, with the equilibrium strongly shifted towards the reduced form as compared to its structural homologue, thioredoxin…”
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Microbial relatives of seed storage proteins: conservation of motifs in a functionally diverse superfamily of enzymes by Dunwell, J.M. (The University of Reading, Whiteknights, Reading, UK.), Gane, P.J

“…Plant storage proteins comprise a major part of the human diet. Sequence analysis has revealed that these proteins probably share a common ancestor with a…”
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Modeling based on the structure of vicilins predicts a histidine cluster in the active site of oxalate oxidase by Gane, P.J. (University of Cambridge, Cambridge, UK.), Dunwell, J.M, Warwicker, J

“…It is known that germin, which is a marker of the onset of growth in germinating wheat, is an oxalate oxidase, and also that germins possess sequence…”
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Experimental and theoretical analyses of the domain architecture of mammalian protein disulphide-isomerase by Freedman, R B, Gane, P J, Hawkins, H C, Hlodan, R, McLaughlin, S H, Parry, J W

“…The high resolution structure of full-length protein disulphide-isomerase (PDI) has not been determined, but the polypeptide is generally assumed to comprise a…”
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A Model for Prion Protein Dimerisation Based on α-Helical Packing by Warwicker, James, Gane, Paul J.

“…Residues 109–122 of the human prion protein (PrP) are highly conserved across species, and are predicted to be α-helical in PrPc, the cellular form. A…”
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Oxadiazolylindazole Sodium Channel Modulators are Neuroprotective toward Hippocampal Neurones by Clutterbuck, Lisa A, Posada, Cristina Garcia, Visintin, Cristina, Riddall, Dieter R, Lancaster, Barrie, Gane, Paul J, Garthwaite, John, Selwood, David L

“…We report the discovery of a new class of neuroprotective voltage-dependent sodium channel modulators exemplified by…”
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Calculation of Cys 30 Delta pK sub(a)'s and oxidising power for DsbA mutants by Warwicker, J, Gane, P J

“…DsbA possesses a redox active disulphide, with the equilibrium strongly shifted towards the reduced form as compared to its structural homologue, thioredoxin…”
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Calculation of Cys 30 ΔpK a 's and oxidising power for DsbA mutants by Warwicker, J., Gane, P.J.

“…DsbA possesses a redox active disulphide, with the equilibrium strongly shifted towards the reduced form as compared to its structural homologue, thioredoxin…”
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