Search Results - "Gandy, Michael N"

The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset by Huot, Philippe, Johnston, Tom H, Gandy, Michael N, Reyes, M Gabriela, Fox, Susan H, Piggott, Matthew J, Brotchie, Jonathan M

“…The wearing-OFF phenomenon is a common motor complication of chronic L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for Parkinson's disease. We recently…”
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Synthesis of Kalasinamide, a Putative Plant Defense Phototoxin by Gandy, Michael N., Piggott, Matthew J.

“…The first total synthesis of the azaanthracene kalasinamide (1) is described, and the discrepancy in the reported 13C NMR data and melting points for the…”
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An interactive database to explore herbicide physicochemical properties by Gandy, Michael N, Corral, Maxime G, Mylne, Joshua S, Stubbs, Keith A

“…Herbicides are an essential tool not only in weed management, but also in conservation tillage approaches to cropping. The first commercial herbicides were…”
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Towards aryl C-N bond formation in dynamic thin films by Gandy, Michael N, Raston, Colin L, Stubbs, Keith A

“…C-N bond forming reactions are important in organic chemistry. A thin film microfluidic vortex fluidic device (VFD) operating under confined mode affords…”
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A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates by Gandy, Michael N, Byrne, Lindsay T, Stubbs, Keith A

“…A generalised, simple and efficient synthesis of N-acetyl-5-bromo-4-chloroindoxyl and related analogues required for the synthesis of indigogenic substrates to…”
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A general method for affinity-based proteomic profiling of exo-α-glycosidases by Gandy, Michael N, Debowski, Aleksandra W, Stubbs, Keith A

“…Synthesis of iminosugar-based affinity-based proteomics probes for use in probing exo-α-glycosidase activity…”
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A novel MDMA analogue, UWA‐101, that lacks psychoactivity and cytotoxicity, enhances l‐DOPA benefit in parkinsonian primates by Johnston, Tom H., Millar, Zak, Huot, Philippe, Wagg, Keith, Thiele, Sherri, Salomonczyk, Danielle, Yong‐Kee, Christopher J., Gandy, Michael N., McIldowie, Matthew, Lewis, Katie D., Gomez‐Ramirez, Jordi, Lee, Joohyung, Fox, Susan H., Martin‐Iverson, Mathew, Nash, Joanne E., Piggott, Matthew J., Brotchie, Jonathan M.

“…Treatment of Parkinson's disease with dopaminergic agents, such as l‐DOPA, is frequently compromised by disabling side effects, particularly dyskinesia and a…”
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Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine (‘ecstasy’) through iterative chemical redesign: mechanisms and pathways to cell death by Wasik, Agata M., Gandy, Michael N., McIldowie, Matthew, Holder, Michelle J., Chamba, Anita, Challa, Anita, Lewis, Katie D., Young, Stephen P., Scheel-Toellner, Dagmar, Dyer, Martin J., Barnes, Nicholas M., Piggott, Matthew J., Gordon, John

“…Summary While 3,4-methylenedioxymethamphetamine (MDMA/‘ecstasy’) is cytostatic towards lymphoma cells in vitro, the concentrations required militate against…”
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Physical and crystallographic characterisation of the mGlu5 antagonist MTEP and its monohydrochloride by McIldowie, Matthew J, Gandy, Michael N, Skelton, Brian W, Brotchie, Jonathan M, Koutsantonis, George A, Spackman, Mark A, Piggott, Matthew J

“…An improved medium scale synthesis of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP), a selective and potent metabotropic glutamate subtype 5 (mGlu5)…”
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Enzymatic Metabolism of Ergosterol by Cytochrome P450scc to Biologically Active 17α,24-Dihydroxyergosterol by Slominski, Andrzej, Semak, Igor, Zjawiony, Jordan, Wortsman, Jacobo, Gandy, Michael N., Li, Jinghu, Zbytek, Blazej, Li, Wei, Tuckey, Robert C.

“…We demonstrate the metabolism of ergosterol by cytochrome P450scc in either a reconstituted system or isolated adrenal mitochondria. The major reaction product…”
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Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol by Slominski, Andrzej, Semak, Igor, Zjawiony, Jordan, Wortsman, Jacobo, Gandy, Michael N, Li, Jinghu, Zbytek, Blazej, Li, Wei, Tuckey, Robert C

“…We demonstrate the metabolism of ergosterol by cytochrome P450scc in either a reconstituted system or isolated adrenal mitochondria. The major reaction product…”
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