Search Results - "Gandolfi, A.Jay"

Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexico by Meza, Maria Mercedes, Kopplin, Michael J., Burgess, Jefferey L., Gandolfi, A.Jay

“…The objective of this study was to determine arsenic exposure via drinking water and to characterize urinary arsenic excretion among adults in the Yaqui…”
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Precision-cut tissue slices: applications in pharmacology and toxicology by Parrish, A R, Gandolfi, A J, Brendel, K

“…Almost a decade has passed since the first paper describing the isolation and maintenance of precision-cut liver slices produced using a mechanical tissue…”
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Selective Activation in the MAPK Pathway by Hg(II) in Precision-Cut Rabbit Renal Cortical Slices by Turney, Karen D., Parrish, Alan R., Orozco, Jason, Gandolfi, A.Jay

“…The kidneys are the primary organ for the accumulation and toxicity of inorganic mercury. In these studies the molecular response of precision-cut rabbit renal…”
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Late Dimethyl Sulfoxide Administration Provides a Protective Action against Chemically Induced Injury in both the Liver and the Kidney by Lind, Richard C., Gandolfi, A.Jay

“…Dimethyl sulfoxide (DMSO) can protect the liver from injury produced by a variety of hepatotoxicants when administered prior to or concomitant with the…”
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Use of tissue slices in chemical mixture toxicology and interspecies investigations by Gandolfi, A.Jay, Brendel, Klaus, Fisher, Robyn L., Michaud, John-Pierre

“…Precision-cut tissue slices have proven to be a useful in vitro system for biotransformation and toxicity studies. Since tissue slices can be readily prepared…”
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The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review by Carter, Dean E, Aposhian, H.Vasken, Gandolfi, A.Jay

“…The aim of this review is to compare the metabolism, chemistry, and biological effects to determine if either of the industrial arsenicals (arsine and gallium…”
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Cocaine hepatotoxicity in cultured liver slices: a species comparison by Connors, S, Rankin, D R, Gandolfi, A J, Krumdieck, C L, Koep, L J, Brendel, K

“…Studies were carried out in order to find a sensitive in vitro model with which to investigate cocaine-mediated hepatotoxicity. Precision-cut liver slices were…”
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In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system by Smith, P F, Fisher, R, Shubat, P J, Gandolfi, A J, Krumdieck, C L, Brendel, K

“…Two well-known hepatotoxicants, allyl alcohol (AA) and bromobenzene (BB), were studied using an in vitro system of cultured liver slices from control and…”
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Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels by Bredfeldt, Tiffany G, Kopplin, Micheal J, Gandolfi, A.Jay

“…Chronic arsenic exposure increases risk for the development of diabetes, vascular disease, and cancers of the skin, lung, kidney, and bladder. This study…”
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Low-level arsenite induced gene expression in HEK293 cells by Zheng, Xing Hui, Watts, George S., Vaught, Skip, Gandolfi, A.Jay

“…Chronic, low-level exposure to arsenic frequently results in skin, lung, bladder, and kidney cancer. Since arsenic is primarily excreted via the kidney, this…”
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Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury by Begay, Carmen K, Gandolfi, A.Jay

“…Our previous studies have described the protective effects of hepatoprotective agents against liver injury elicited by chloroform even when given 24 h after…”
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Hepatoprotection by Dimethyl Sulfoxide: III. Role of Inhibition of the Bioactivation and Covalent Binding of Chloroform by Lind, Richard C., Begay, Carmen K., Gandolfi, A.Jay

“…Dimethyl sulfoxide (DMSO) has previously been shown to have the ability to attenuate chloroform (CHCl3)-induced liver injury in the naive rat even when…”
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Benzo(a)pyrene-Induced Alterations in Growth-Related Gene Expression and Signaling in Precision-Cut Adult Rat Liver and Kidney Slices by Parrish, Alan R, Fisher, Robyn, Bral, Christopher M, Burghardt, Robert C, Gandolfi, A.Jay, Brendel, Klaus, Ramos, Kenneth S

“…Benzo(a)pyrene (BaP) and related aromatic hydrocarbons are suspected carcinogens; however, the molecular basis underlying tumorigenesis remains unclear. To…”
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Hepatoprotection by Dimethyl Sulfoxide by Lind, Richard C., Begay, Carmen K., Gandolfi, A.Jay

“…Dimethyl sulfoxide (DMSO) has previously been shown to have the ability to attenuate chloroform (CHCl sub(3))-induced liver injury in the naive rat even when…”
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Demonstration of a Cellular Immune Response in Halothane-Exposed Guinea Pigs by Furst, Sylvia M., Luedke, Dennis, Gaw, Htoo-Htoo, Reich, Richard, Gandolfi, A.Jay

“…Halothane hepatitis is considered to be a result of an idiosyncratic autoimmune reaction brought about by the formation of neoantigens that have been generated…”
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Further examination of the selective toxicity of CCl4 in rat liver slices by Azri, S, Mata, H P, Reid, L L, Gandolfi, A J, Brendel, K

“…Lipid peroxidation and loss of enzymes located predominantly in either periportal or centrilobular hepatocytes were investigated in precision-cut liver slices…”
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Glutathione-S-transferase is a target for covalent modification by a halothane reactive intermediate in the guinea pig liver by Brown, A P, Gandolfi, A J

“…The anesthetic halothane is bioactivated by the liver cytochrome P450 system to the reactive intermediate, trifluoroacetyl chloride, which can acylate liver…”
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Cold- and cryopreservation of human liver and kidney slices by Fisher, R L, Hasal, S J, Sanuik, J T, Scott, K S, Gandolfi, A J, Brendel, K

“…Tissue slices may provide a rapid and economical way of determining cold ischemic effects on human liver and kidney cell viability and metabolism. In contrast…”
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Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions by Ruegg, C E, Gandolfi, A J, Nagle, R B, Brendel, K

“…The innate susceptibility of renal cell types to these agents was investigated using precision-cut rabbit renal cortical slices made perpendicular to the…”
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The hepatotoxicity of chloroform in precision-cut rat liver slices by Azri-Meehan, S, Mata, H P, Gandolfi, A J, Brendel, K

“…Chloroform hepatotoxicity was investigated in precision-cut liver slices from male Sprague-Dawley rats pretreated with phenobarbital to predispose animals to…”
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