Search Results - "Gandini, María A."

Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release by Gandini, María A., Sandoval, Alejandro, González-Ramírez, Ricardo, Mori, Yasuo, de Waard, Michel, Felix, Ricardo

“…Insulin release by pancreatic β-cells is regulated by diverse intracellular signals, including changes in Ca2+ concentration resulting from Ca2+ entry through…”
Get full text

Navigating the Controversies: Role of TRPM Channels in Pain States by Gandini, Maria A, Zamponi, Gerald W

“…Chronic pain is a debilitating condition that affects up to 1.5 billion people worldwide and bears a tremendous socioeconomic burden. The success of pain…”
Get full text

Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway by Sandoval, Alejandro, Duran, Paz, Gandini, María A., Andrade, Arturo, Almanza, Angélica, Kaja, Simon, Felix, Ricardo

“…[Display omitted] •The activation of the NO-cGMP-PKG pathway inhibits native and recombinant L-type calcium channels.•Application of 8-Br-cGMP inhibits calcium…”
Get full text

CaV3.2 calcium channels contribute to trigeminal neuralgia by Gambeta, Eder, Gandini, Maria A., Souza, Ivana A., Zamponi, Gerald W.

“…Trigeminal neuralgia (TN) is a rare but debilitating disorder characterized by excruciating facial pain, with a higher incidence in women. Recent studies…”
Get full text

Functional interactions between voltage-gated Ca(2+) channels and Rab3-interacting molecules (RIMs): new insights into stimulus-secretion coupling by Gandini, María A, Felix, Ricardo

“…Stimulus-secretion coupling is a complex set of intracellular reactions initiated by an external stimulus that result in the release of hormones and…”
Get more information

Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk by Huang, Junting, Gandini, Maria A., Chen, Lina, M’Dahoma, Said, Stemkowski, Patrick L., Chung, Hyunjae, Muruve, Daniel A., Zamponi, Gerald W.

“…The innate immune system responds to infections that give rise to pain. How the innate immune system interacts with the sensory nervous system and contributes…”
Get full text

A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav2.2 channels and utility in neuropathic pain by Kricek, Franz, Ruf, Christine, Meghani, Premji, Souza, Ivana A., Gandini, Maria A., Zamponi, Gerald W., Skouteris, George

“…The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in…”
Get full text

RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors by Grabner, Chad P, Gandini, Maria A, Rehak, Renata, Le, Yun, Zamponi, Gerald W, Schmitz, Frank

“…Night blindness can result from impaired photoreceptor function and a subset of cases have been linked to dysfunction of Cav1.4 calcium channels and in turn…”
Get full text

Determinants of interactions of a novel next-generation gabapentinoid NVA1309 and mirogabalin with the Cavα2δ-1 subunit by Souza, Ivana A, Gandini, Maria A, Ali, Md Yousof, Kricek, Franz, Skouteris, George, Zamponi, Gerald W

“…NVA1309 is a non-brain penetrant next-generation gabapentinoid shown to bind Cavα2δ at R243 within a triple Arginine motif forming the binding site for…”
Get full text

Functional interactions between voltage-gated Ca2+ channels and Rab3-interacting molecules (RIMs): New insights into stimulus–secretion coupling by Gandini, María A., Felix, Ricardo

“…Stimulus–secretion coupling is a complex set of intracellular reactions initiated by an external stimulus that result in the release of hormones and…”
Get full text

Splice-variant specific effects of a CACNA1H mutation associated with writer's cramp by Souza, Ivana A, Gandini, Maria A, Zamponi, Gerald W

“…The CACNA1H gene encodes the α1 subunit of the low voltage-activated Ca 3.2 T-type calcium channel, an important regulator of neuronal excitability…”
Get full text

A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels by Gambeta, Eder, Gandini, Maria A, Souza, Ivana A, Ferron, Laurent, Zamponi, Gerald W

“…A novel missense mutation in the CACNA1A gene that encodes the pore forming α subunit of the Ca 2.1 voltage-gated calcium channel was identified in a patient…”
Get full text

The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function by Gandini, Maria A, Souza, Ivana A, Ferron, Laurent, Innes, A Micheil, Zamponi, Gerald W

“…CACNA1A pathogenic variants have been linked to several neurological disorders including familial hemiplegic migraine and cerebellar conditions. More recently,…”
Get full text

CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation by Gandini, María A., Henríquez, Daniel R., Grimaldo, Lizbeth, Sandoval, Alejandro, Altier, Christophe, Zamponi, Gerald W., Felix, Ricardo, González-Billault, Christian

“…Microtubule-associated protein B is a cytoskeleton protein consisting of heavy and light (LC) chains that play important roles in the regulation of neuronal…”
Get full text

Toxins targeting voltage-activated Ca2+ channels and their potential biomedical applications by Gandini, María A, Sandoval, Alejandro, Felix, Ricardo

“…Voltage-gated Ca(2+) (CaV) channels are transmembrane proteins primarily formed by an ion-conducting α 1 subunit that can associate with auxiliary β and α2δ…”
Get more information

Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels by Ficelova, Vendula, Souza, Ivana A, Cmarko, Leos, Gandini, Maria A, Stringer, Robin N, Zamponi, Gerald W, Weiss, Norbert

“…Abstract Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels…”
Get full text

Functional expression of T-type Ca2+ channels in spinal motoneurons of the adult turtle by Canto-Bustos, Martha, Loeza-Alcocer, Emanuel, González-Ramírez, Ricardo, Gandini, María A, Delgado-Lezama, Rodolfo, Felix, Ricardo

“…Voltage-gated Ca2+ (CaV) channels are transmembrane proteins comprising three subfamilies named CaV1, CaV2 and CaV3. The CaV3 channel subfamily groups the…”
Get full text

Interactions of Rabconnectin-3 with Cav2 calcium channels by Gandini, Maria A, Souza, Ivana A, Fan, Jing, Li, Katherine, Wang, Decheng, Zamponi, Gerald W

“…This study describes the interaction between Cav2 calcium channels and Rabconnectin-3, a di-subunit protein that is associated with synaptic vesicles…”
Get full text

Functional remodeling of presynaptic voltage-gated calcium channels in superficial layers of the dorsal horn during neuropathic pain by Ferron, Laurent, Harding, Erika K., Gandini, Maria A., Brideau, Craig, Stys, Peter K., Zamponi, Gerald W.

“…N- and P/Q-type voltage-gated Ca2+ channels are critical for synaptic transmission. While their expression is increased in the dorsal root ganglion (DRG)…”
Get full text

Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors by Gandini, Maria A., Souza, Ivana A., Raval, Dvij, Xu, Jin, Pan, Ying-Xian, Zamponi, Gerald W.

“…Abstract We have examined the regulation of mutually exclusive Cav2.2 exon 37a and b variants by the mouse μ-opioid receptor (mMOR) C-terminal splice variants…”
Get full text