Search Results - "Gandhi, Rajesh B"

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements by Badkar, Advait V, Gandhi, Rajesh B, Davis, Shawn P, LaBarre, Michael J

“…Subcutaneous (SC) delivery of biologics has traditionally been limited to fluid volumes of 1-2 mL, with recent increases to volumes of about 3 mL. This…”
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Grouping solvents by statistical analysis of solvent property parameters: implication to polymorph screening by Gu, Chong-Hui, Li, Hua, Gandhi, Rajesh B, Raghavan, Krishnaswamy

“…The success rate of discovering new polymorphs by crystallization from solution may be increased if solvents with diverse properties are used during initial…”
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Predicting effect of food on extent of drug absorption based on physicochemical properties by GU, Chong-Hui, HUA LI, LEVONS, Jaquan, LENTZ, Kimberley, GANDHI, Rajesh B, RAGHAVAN, Krishnaswamy, SMITH, Ronald L

“…To develop a statistical model for predicting effect of food on the extent of absorption (area under the curve of time-plasma concentration profile, AUC) of…”
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Investigation of monoclonal antibody fragmentation artifacts in non-reducing SDS-PAGE by Zhu, Zhiqing C., Chen, Yingchen, Ackerman, Michael S., Wang, Bei, Wu, Wei, Li, Bo, Obenauer-Kutner, Linda, Zhao, Rulin, Tao, Li, Ihnat, Peter M., Liu, Jinping, Gandhi, Rajesh B., Qiu, Bo

“…•First study that systematically compared IAM/NEM in SDS-PAGE artifact inhibition.•The artifact inhibition activity of both agents is concentration…”
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Buffer exchange path influences the stability and viscosity upon storage of a high concentration protein by Krause, Mary E., Narang, Ajit S., Barker, Gregory, Herzer, Sibylle, Deshmukh, Smeet, Lan, Wenkui, Fichana, Daniel, Wasylyk, John M., Demirdirek, Bahar, Zhang, Limin, Fiske, John, McGann, Matthew, Adams, Monica L., Gandhi, Rajesh B.

“…[Display omitted] High concentration protein solutions are generally produced by spin column concentration (SCC) during early development and by tangential…”
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Enhancement of oral bioavailability of an HIV-attachment inhibitor by nanosizing and amorphous formulation approaches by Fakes, Michael G., Vakkalagadda, Blisse J., Qian, Feng, Desikan, Sridhar, Gandhi, Rajesh B., Lai, Chiajen, Hsieh, Alice, Franchini, Miriam K., Toale, Helen, Brown, Jonathan

“…BMS-488043 is an HIV-attachment inhibitor that exhibited suboptimal oral bioavailability upon using conventional dosage forms prepared utilizing micronized…”
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Importance of using physiologically relevant volume of dissolution medium to correlate the oral exposure of formulations of BMS-480188 mesylate by Gu, Chong-Hui, Gandhi, Rajesh B., Tay, Lee K., Zhou, Simon, Raghavan, Krishnaswamy

“…BMS-480188 is a weak base. The aqueous solubility of BMS-480188 is 0.036 mg/ml at pH 6.5 at 37 °C. The mesylate salt of BMS-480188 was prepared to improve its…”
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Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility by Gu, Chong-Hui, Rao, Deepa, Gandhi, Rajesh B, Hilden, Jon, Raghavan, Krishnaswamy

“…A novel multicompartment dissolution system was developed by modifying a conventional six-vessel United States Pharmacopoeia dissolution system to study the…”
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Scale considerations for selection of saccharide excipients for liquid formulations by Zhou, Rong, Schlam, Roxana F, Yin, Shawn, Gandhi, Rajesh B, Adams, Monica L

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Predicting Effect of Food on Extent of Drug Absorption Based on Physicochemical Properties by Gu, Chong-Hui, Li, Hua, Levons, Jaquan, Lentz, Kimberley, Gandhi, Rajesh B., Raghavan, Krishnaswamy, Smith, Ronald L.

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Investigation of freeze/thaw-related quality attributes of a liquid biopharmaceutical formulation: the role of saccharide excipients by Zhou, Rong, Schlam, Roxana F, Yin, Shawn, Gandhi, Rajesh B, Adams, Monica L

“…Saccharides, including sucrose, trehalose, mannitol, and sorbitol, are commonly employed as stabilizers, cryoprotectants, and/or tonicity adjusters in protein…”
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Subcutaneous Delivery of High-Dose/Volume Biologies: Current Status and Prospect for Future Advancements by Badkar, Advait V, Gandhi, Rajesh B, Davis, Shawn P, LaBarre, Michael J

“…Subcutaneous (SC) delivery of biologies has traditionally been limited to fluid volumes of 1-2 mL, with recent increases to volumes of about 3 mL. This…”
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Some permselectivity and permeability characteristics of rabbit buccal mucosa by Gandhi, Rajesh B

“…Some permselectivity and permeability characteristics of the rabbit buccal mucosa, as related to buccal absorption of drugs, were investigated. Transport…”
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