Search Results - "Gandhi, Pauravi"

Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model by Ravikrishnan, Aparna, Gandhi, Pauravi J., Shelkar, Gajanan P., Liu, Jinxu, Pavuluri, Ratnamala, Dravid, Shashank M.

“…[Display omitted] •GluN2C is expressed in parvalbumin-positive neurons in a subset of basal ganglia nuclei.•GluN2C is localized to astrocytes in majority of…”
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The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder by Varodayan, Florence P., Patel, Reesha R., Matzeu, Alessandra, Wolfe, Sarah A., Curley, Dallece E., Khom, Sophia, Gandhi, Pauravi J., Rodriguez, Larry, Bajo, Michal, D’Ambrosio, Shannon, Sun, Hui, Kerr, Tony M., Gonzales, Rueben A., Leggio, Lorenzo, Natividad, Luis A., Haass-Koffler, Carolina L., Martin-Fardon, Rémi, Roberto, Marisa

“…Alcohol use disorder (AUD) is a leading preventable cause of death. The central amygdala (CeA) is a hub for stress and AUD, while dysfunction of the…”
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Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats by Khom, Sophia, Rodriguez, Larry, Gandhi, Pauravi, Kirson, Dean, Bajo, Michal, Oleata, Christopher S., Vendruscolo, Leandro F., Mason, Barbara J., Roberto, Marisa

“…Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in alcohol use disorder (AUD). Acute alcohol withdrawal and…”
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Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity by Liu, Jinxu, Shelkar, Gajanan P., Gandhi, Pauravi J., Gawande, Dinesh Y., Hoover, Andrew, Villalba, Rosa M., Pavuluri, Ratnamala, Smith, Yoland, Dravid, Shashank M.

“…Impaired behavioral flexibility and repetitive behavior is a common phenotype in autism and other neuropsychiatric disorders, but the underlying synaptic…”
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Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses by Kirson, Dean, Khom, Sophia, Rodriguez, Larry, Wolfe, Sarah A, Varodayan, Florence P, Gandhi, Pauravi J, Patel, Reesha R, Vlkolinsky, Roman, Bajo, Michal, Roberto, Marisa

“…Abstract Aims Alcohol use disorder (AUD) is linked to hyperactivity of brain stress systems, leading to withdrawal states which drive relapse. AUD differs…”
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Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice by Kreifeldt, Max, Herman, Melissa A., Sidhu, Harpreet, Okhuarobo, Agbonlahor, Macedo, Giovana C., Shahryari, Roxana, Gandhi, Pauravi J., Roberto, Marisa, Contet, Candice

“…Corticotropin-releasing factor (CRF) signaling in the central nucleus of the amygdala (CeA) plays a critical role in rodent models of excessive alcohol…”
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Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol by Patel, Reesha R., Wolfe, Sarah A., Borgonetti, Vittoria, Gandhi, Pauravi J., Rodriguez, Larry, Snyder, Angela E., D’Ambrosio, Shannon, Bajo, Michal, Domissy, Alain, Head, Steven, Contet, Candice, Dayne Mayfield, R., Roberts, Amanda J., Roberto, Marisa

“…Prefrontal circuits are thought to underlie aberrant emotion contributing to relapse in abstinence; however, the discrete cell-types and mechanisms remain…”
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The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function by Gupta, Subhash C., Ravikrishnan, Aparna, Liu, Jinxu, Mao, Zhihao, Pavuluri, Ratnamala, Hillman, Brandon G., Gandhi, Pauravi J., Stairs, Dustin J., Li, Ming, Ugale, Rajesh R., Monaghan, Daniel T., Dravid, Shashank M.

“…Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes…”
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Ethanol’s interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice by Okhuarobo, Agbonlahor, Kreifeldt, Max, Gandhi, Pauravi J., Lopez, Catherine, Martinez, Briana, Fleck, Kiera, Bajo, Michal, Bhattacharyya, Pushpita, Dopico, Alex M., Roberto, Marisa, Roberts, Amanda J., Homanics, Gregg E., Contet, Candice

“…Large conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit…”
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Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses by Rodriguez, Larry, Kirson, Dean, Wolfe, Sarah A, Patel, Reesha R, Varodayan, Florence P, Snyder, Angela E, Gandhi, Pauravi J, Khom, Sophia, Vlkolinsky, Roman, Bajo, Michal, Roberto, Marisa

“…Alcohol use disorder (AUD) is a chronically relapsing disease characterized by loss of control in seeking and consuming alcohol (ethanol) driven by the…”
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Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens by Shelkar, Gajanan P, Gandhi, Pauravi J, Liu, Jinxu, Dravid, Shashank M

“…Cocaine-associated memories induce cravings and interfere with the ability of users to cease cocaine use. Reducing the strength of cue-drug memories by…”
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Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes by Shelkar, Gajanan P., Pavuluri, Ratnamala, Gandhi, Pauravi J., Ravikrishnan, Aparna, Gawande, Dinesh Y., Liu, Jinxu, Stairs, Dustin J., Ugale, Rajesh R., Dravid, Shashank M.

“…The GluN2C- and GluN2D-containing NMDA receptors are distinct from GluN2A- and GluN2B-containing receptors in many aspects including lower sensitivity to Mg 2+…”
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Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens by Liu, Jinxu, Gandhi, Pauravi J., Pavuluri, Ratnamala, Shelkar, Gajanan P., Dravid, Shashank M.

“…Cocaine exposure induces plasticity of glutamatergic synapses of medium spiny neurons (MSNs) in the nucleus accumbens (NAc), which has been proposed to…”
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Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats by Khom, Sophia, Borgonetti, Vittoria, Vozella, Valentina, Kirson, Dean, Rodriguez, Larry, Gandhi, Pauravi, Bianchi, Paula Cristina, Snyder, Angela, Vlkolinsky, Roman, Bajo, Michal, Oleata, Christopher S., Ciccocioppo, Roberto, Roberto, Marisa

“…Impairments in the function of the hypothalamic-pituitary-adrenal (HPA) axis and enhanced glucocorticoid receptor (GR) activity in the central amygdala (CeA)…”
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Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain by Gandhi, Pauravi J, Gawande, Dinesh Y, Shelkar, Gajanan P, Gakare, Sukanya G, Kiritoshi, Takaki, Ji, Guangchen, Misra, Bishal, Pavuluri, Ratnamala, Liu, Jinxu, Neugebauer, Volker, Dravid, Shashank M

“…Chronic pain is a debilitating condition involving neuronal dysfunction, but the synaptic mechanisms underlying the persistence of pain are still poorly…”
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Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure by Patel, Reesha R., Gandhi, Pauravi, Spencer, Kathryn, Salem, Nihal A., Erikson, Chloe. M., Borgonetti, Vittoria, Vlkolinsky, Roman, Rodriguez, Larry, Nadav, Tali, Bajo, Michal, Roberts, Amanda J., Dayne Mayfield, R., Roberto, Marisa

“…Chronic ethanol dependence and withdrawal activate corticotropin releasing factor (CRF)-containing GABAergic neurons in the medial prefrontal cortex (mPFC),…”
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Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein by Haass-Koffler, Carolina L., Francis, T. Chase, Gandhi, Pauravi, Patel, Reesha, Naemuddin, Mohammad, Nielsen, Carsten K., Bartlett, Selena E., Bonci, Antonello, Vasile, Stefan, Hood, Becky L., Suyama, Eigo, Hedrick, Michael P., Smith, Layton H., Limpert, Allison S., Roberto, Marisa, Cosford, Nicholas D.P., Sheffler, Douglas J.

“…Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF1 and CRF2), and the CRF-binding protein (CRFBP)…”
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Cell‐type specific expression of GluN2C and GluN2D subunits and their role in schizophrenic phenotypes by Gandhi, Pauravi J, Shelkar, Gajanan J, Pavuluri, Ratna, Liu, Jinxu, Dravid, Shashank M

“…Introduction Functional deficit in NMDA‐receptors on parvalbumin (PV)‐positive interneurons (PV‐NMDARs) is central to the pathophysiology of schizophrenia…”
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Organisation of Glutamatergic Inputs to Central Amygdala by Gandhi, Pauravi J

“…Chronic pain is a major public health problem, leading to long term disability and distress that makes its clinical management challenging. Central amygdala…”
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