Search Results - "Gandhi, Neel R"

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis by Gandhi, Neel R, Dr, Nunn, Paul, FRCP, Dheda, Keertan, PhD, Schaaf, H Simon, Prof, Zignol, Matteo, MD, van Soolingen, Dick, PhD, Jensen, Paul, PhD, Bayona, Jaime, MD

“…Summary Although progress has been made to reduce global incidence of drug-susceptible tuberculosis, the emergence of multidrug-resistant (MDR) and extensively…”
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Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis by Dheda, Keertan, Prof, Gumbo, Tawanda, MD, Gandhi, Neel R, PhD, Murray, Megan, ScD, Theron, Grant, PhD, Udwadia, Zarir, MD, Migliori, G B, MD, Warren, Robin, PhD

“…Summary Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting economically active young adults, and has high mortality…”
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Tuberculosis Infectiousness and Host Susceptibility by Turner, Richard D., Chiu, Christopher, Churchyard, Gavin J., Esmail, Hanif, Lewinsohn, David M., Gandhi, Neel R., Fennelly, Kevin P.

“…The transmission of tuberculosis is complex. Necessary factors include a source case with respiratory disease that has developed sufficiently for Mycobacterium…”
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Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysis by Orenstein, Evan W, BS, Basu, Sanjay, PhD, Shah, N Sarita, MD, Andrews, Jason R, MD, Friedland, Gerald H, MD, Moll, Anthony P, MBChB, Gandhi, Neel R, MD, Galvani, Alison P, PhD

“…Summary Multidrug-resistant (MDR) tuberculosis is a growing clinical and public-health concern. To evaluate existing evidence regarding treatment regimens for…”
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Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities by Auld, Sara C, Shah, N Sarita, Mathema, Barun, Brown, Tyler S, Ismail, Nazir, Omar, Shaheed Vally, Brust, James C M, Nelson, Kristin N, Allana, Salim, Campbell, Angela, Mlisana, Koleka, Moodley, Pravi, Gandhi, Neel R

“…Despite evidence that transmission is driving an extensively drug-resistant TB (XDR-TB) epidemic, our understanding of where and between whom transmission…”
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TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis by Collins, Jeffrey M, Jones, Dean P, Sharma, Ashish, Khadka, Manoj, Liu, Ken H, Kempker, Russell R, Prideaux, Brendan, Maner-Smith, Kristal, Tukvadze, Nestani, Shah, N. Sarita, Brust, James C. M, Sékaly, Rafick-Pierre, Gandhi, Neel R, Blumberg, Henry M, Ortlund, Eric A, Ziegler, Thomas R

“…The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using…”
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Simple Estimates for Local Prevalence of Latent Tuberculosis Infection, United States, 2011-2015 by Haddad, Maryam B, Raz, Kala M, Lash, Timothy L, Hill, Andrew N, Kammerer, J Steve, Winston, Carla A, Castro, Kenneth G, Gandhi, Neel R, Navin, Thomas R

“…We used tuberculosis genotyping results to derive estimates of prevalence of latent tuberculosis infection in the United States. We estimated <1% prevalence in…”
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Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan by Malik, Amyn A, Gandhi, Neel R, Lash, Timothy L, Cranmer, Lisa M, Omer, Saad B, Ahmed, Junaid F, Siddiqui, Sara, Amanullah, Farhana, Khan, Aamir J, Keshavjee, Salmaan, Hussain, Hamidah, Becerra, Mercedes C

“…In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis (TB) and low HIV prevalence, we assessed the effectiveness of…”
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Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs by Sharan, Riti, Ganatra, Shashank R, Singh, Dhiraj K, Cole, Journey, Foreman, Taylor W, Thippeshappa, Rajesh, Peloquin, Charles A, Shivanna, Vinay, Gonzalez, Olga, Day, Cheryl L, Gandhi, Neel R, Dick, Jr, Edward J, Hall-Ursone, Shannan, Mehra, Smriti, Schlesinger, Larry S, Rengarajan, Jyothi, Kaushal, Deepak

“…A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The…”
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Hepatitis C care cascade among patients with and without tuberculosis: Nationwide observational cohort study in the country of Georgia, 2015-2020 by Baliashvili, Davit, Blumberg, Henry M, Gandhi, Neel R, Averhoff, Francisco, Benkeser, David, Shadaker, Shaun, Gvinjilia, Lia, Turdziladze, Aleksandre, Tukvadze, Nestani, Chincharauli, Mamuka, Butsashvili, Maia, Sharvadze, Lali, Tsertsvadze, Tengiz, Zarkua, Jaba, Kempker, Russell R

“…The Eastern European country of Georgia initiated a nationwide hepatitis C virus (HCV) elimination program in 2015 to address a high burden of infection…”
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High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa by Niehaus, Abraham J, Mlisana, Koleka, Gandhi, Neel R, Mathema, Barun, Brust, James C M

“…Drug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options…”
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Exogenous Reinfection as a Cause of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in Rural South Africa by Andrews, Jason R., Gandhi, Neel R., Moodley, Prashini, Shah, N. Sarita, Bohlken, Louise, Moll, Anthony P., Pillay, Manormoney, Friedland, Gerald, Sturm, A. Willem

“…Background. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are now major threats in areas of South Africa with a high…”
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pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia by Allana, Salim, Shashkina, Elena, Mathema, Barun, Bablishvili, Nino, Tukvadze, Nestani, Shah, N Sarita, Kempker, Russell R, Blumberg, Henry M, Moodley, Pravi, Mlisana, Koleka, Brust, James C M, Gandhi, Neel R

“…Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA…”
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Distinct Human NK Cell Phenotypes and Functional Responses to Mycobacterium tuberculosis in Adults From TB Endemic and Non-endemic Regions by Harris, Levelle D, Khayumbi, Jeremiah, Ongalo, Joshua, Sasser, Loren E, Tonui, Joan, Campbell, Angela, Odhiambo, Felix Hayara, Ouma, Samuel Gurrion, Alter, Galit, Gandhi, Neel R, Day, Cheryl L

“…(Mtb) is the causative agent of tuberculosis (TB), which leads to an estimated 1. 5 million deaths worldwide each year. Although the immune correlates of…”
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CD4 T Cells in Mycobacterium tuberculosis and Schistosoma mansoni Co-infected Individuals Maintain Functional TH1 Responses by McLaughlin, Taryn A, Khayumbi, Jeremiah, Ongalo, Joshua, Tonui, Joan, Campbell, Angela, Allana, Salim, Gurrion Ouma, Samuel, Odhiambo, Felix Hayara, Gandhi, Neel R, Day, Cheryl L

“…(Mtb) is a serious public health concern, infecting a quarter of the world and leading to 10 million cases of tuberculosis (TB) disease and 1. 5 million deaths…”
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Predictors of multidrug- and extensively drug-resistant tuberculosis in a high HIV prevalence community by Andrews, Jason R, Shah, N Sarita, Weissman, Darren, Moll, Anthony P, Friedland, Gerald, Gandhi, Neel R

“…Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) have emerged in high-HIV-prevalence settings, which generally lack laboratory…”
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Spatial distribution of extensively drug-resistant tuberculosis (XDR TB) patients in KwaZulu-Natal, South Africa by Kapwata, Thandi, Morris, Natashia, Campbell, Angela, Mthiyane, Thuli, Mpangase, Primrose, Nelson, Kristin N, Allana, Salim, Brust, James C M, Moodley, Pravi, Mlisana, Koleka, Gandhi, Neel R, Shah, N Sarita

“…KwaZulu-Natal province, South Africa, has among the highest burden of XDR TB worldwide with the majority of cases occurring due to transmission. Poor access to…”
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Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study by Basu, Sanjay, MSc, Andrews, Jason R, MD, Poolman, Eric M, MD, Gandhi, Neel R, MD, Shah, N Sarita, MD, Moll, Anthony, MBChB, Moodley, Prashini, Prof, Galvani, Alison P, PhD, Friedland, Gerald H, Prof

“…Summary Background Extensively drug-resistant (XDR) tuberculosis has spread among hospitalised patients in South Africa, but the epidemic-level effect of…”
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Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa by Magee, Matthew J, Sun, Yan V, Brust, James C M, Shah, N Sarita, Ning, Yuming, Allana, Salim, Campbell, Angela, Hui, Qin, Mlisana, Koleka, Moodley, Pravi, Gandhi, Neel R

“…Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin…”
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Adults from Kisumu, Kenya have robust γδ T cell responses to Schistosoma mansoni, which are modulated by tuberculosis by McLaughlin, Taryn A, Khayumbi, Jeremiah, Ongalo, Joshua, Matete, Daniel, Tonui, Joan, Muchiri, Benson, Sasser, Loren E, Campbell, Angela, Allana, Salim, Ouma, Samuel Gurrion, Hayara, Felix Odhiambo, Gandhi, Neel R, Day, Cheryl L

“…Schistosoma mansoni (SM) is a parasitic helminth that infects over 200 million people and causes severe morbidity. It undergoes a multi-stage life cycle in…”
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