Search Results - "Gandhi, Chandrashekhar R."

Yes‐Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis by Song, Kyoungsub, Kwon, Hyunjoo, Han, Chang, Chen, Weina, Zhang, Jinqiang, Ma, Wenbo, Dash, Srikanta, Gandhi, Chandrashekhar R., Wu, Tong

“…Background and Aims Yes‐associated protein (YAP) plays an important role in hepatocarcinogenesis, although the potential role of YAP in non‐neoplastic liver…”
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Pro- and Anti-fibrogenic Functions of Gram-Negative Bacterial Lipopolysaccharide in the Liver by Gandhi, Chandrashekhar R

“…Extensive research performed over several decades has identified cells participating in the initiation and progression of fibrosis, and the numerous underlying…”
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15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury by Yao, Lu, Chen, Weina, Song, Kyoungsub, Han, Chang, Gandhi, Chandrashekhar R, Lim, Kyu, Wu, Tong

“…The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting…”
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Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice by Kumar, Sudhir, Wang, Jiang, Rani, Richa, Gandhi, Chandrashekhar R

“…Why only a subpopulation (about 15%) of humans develops liver cirrhosis due to alcohol is a critical as yet unanswered question. Liver-specific depletion of…”
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Hepatic stellate cell activation and pro-fibrogenic signals by Gandhi, Chandrashekhar R.

“…Regardless of etiology, hepatic stellate cells (HSCs) are the major contributors to fibrosis/cirrhosis. Bone marrow-derived fibrocytes,…”
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Liver-Specific Deletion of Augmenter of Liver Regeneration Accelerates Development of Steatohepatitis and Hepatocellular Carcinoma in Mice by Gandhi, Chandrashekhar R, Chaillet, J. Richard, Nalesnik, Michael A, Kumar, Sudhir, Dangi, Anil, Demetris, A. Jake, Ferrell, Robert, Wu, Tong, Divanovic, Senad, Stankeiwicz, Traci, Shaffer, Benjamin, Stolz, Donna B, Harvey, Stephen A.K, Wang, Jiang, Starzl, Thomas E

“…Background & Aims Augmenter of liver regeneration (ALR, encoded by GFER ) is a widely distributed pleiotropic protein originally identified as a hepatic growth…”
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Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells by Li, Jiang, Zhang, Yifei, Kuruba, Ramalinga, Gao, Xiang, Gandhi, Chandrashekhar R, Xie, Wen, Li, Song

“…Liver fibrosis is a chronic disorder that is characterized by an alteration of the balance between fibrogenesis and fibrinolysis, which results in accumulation…”
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The transcriptomic response of rat hepatic stellate cells to endotoxin: implications for hepatic inflammation and immune regulation by Harvey, Stephen A K, Dangi, Anil, Tandon, Ashish, Gandhi, Chandrashekhar R

“…With their location in the perisinusoidal space of Disse, hepatic stellate cells (HSCs) communicate with all of the liver cell types both by physical…”
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Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO by Sumpter, Tina L, Dangi, Anil, Matta, Benjamin M, Huang, Chao, Stolz, Donna B, Vodovotz, Yoram, Thomson, Angus W, Gandhi, Chandrashekhar R

“…Hepatic stellate cells (HSCs) are critical for hepatic wound repair and tissue remodeling. They also produce cytokines and chemokines that may contribute to…”
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Toll-Like Receptor 4–Independent Carbon Tetrachloride–Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice by Kumar, Sudhir, Wang, Jiang, Shanmukhappa, Shiva Kumar, Gandhi, Chandrashekhar R

“…Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is implicated in acute and chronic liver injury; its effects are mediated predominantly via the…”
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Stellate cell in hepatic inflammation and acute injury by Rani, Richa, Gandhi, Chandrashekhar R.

“…The perisinusoidal hepatic stellate cells (HSCs) have been investigated extensively for their role as the major fibrogenic cells during chronic liver injury…”
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CD14 is not required for carbon tetrachloride‐induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge by Sharma, Akanksha, Wang, Jiang, Gandhi, Chandrashekhar R.

“…Binding of lipopolysaccharide (LPS) to CD14 is required for its cellular effects via TLR4. A role of LPS/TLR4‐mediated signaling in activated hepatic stellate…”
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Augmenter of liver regeneration: Mitochondrial function and steatohepatitis by Verma, Alok Kumar, Sharma, Akanksha, Subramaniyam, Nithyananthan, Gandhi, Chandrashekhar R.

“…Augmenter of liver regeneration (ALR), a ubiquitous fundamental life protein, is expressed more abundantly in the liver than other organs. Expression of ALR is…”
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The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis by Flood, Hannah M, Bolte, Craig, Dasgupta, Nupur, Sharma, Akanksha, Zhang, Yufang, Gandhi, Chandrashekhar R, Kalin, Tanya V, Kalinichenko, Vladimir V

“…Hepatic fibrosis is the common end stage to a variety of chronic liver injuries and is characterized by an excessive deposition of extracellular matrix (ECM),…”
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"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress by Vodovotz, Yoram, Simmons, Richard L, Gandhi, Chandrashekhar R, Barclay, Derek, Jefferson, Bahiyyah S, Huang, Chao, Namas, Rami, El-Dehaibi, Fayten, Mi, Qi, Billiar, Timothy R, Zamora, Ruben

“…We hypothesized that isolated primary mouse hepatic stellate cells (HSC) and hepatocytes (HC) would elaborate different inflammatory responses to hypoxia with…”
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Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice by Quillin III, Ralph C., Wilson, Gregory C., Nojima, Hiroyuki, Freeman, Christopher M., Wang, Jiang, Schuster, Rebecca M., Blanchard, John A., Edwards, Michael J., Gandhi, Chandrashekhar R., Gulbins, Erich, Lentsch, Alex B.

“…Aim Liver fibrosis occurs as a result of several chronic liver diseases and leads to portal hypertension, cirrhosis and liver failure, often requiring liver…”
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Transgenic Expression of Cyclooxygenase-2 in Hepatocytes Accelerates Endotoxin-Induced Acute Liver Failure by Han, Chang, Li, Guiying, Lim, Kyu, DeFrances, Marie C, Gandhi, Chandrashekhar R, Wu, Tong

“…Bacterial LPS (endotoxin) is implicated in the pathogenesis of acute liver failure and several chronic inflammatory liver diseases. To evaluate the effect of…”
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miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression by Li, Jiang, Ghazwani, Mohammed, Zhang, Yifei, Lu, Jianqin, Li, Jilong, Fan, Jie, Gandhi, Chandrashekhar R, Li, Song

“…Background & Aims MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been…”
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Differential recruitment of monocyte‐derived macrophages in control and stellate cell‐depleted mice during recurrent carbon tetrachloride‐induced acute liver injury by Sharma, Akanksha, Kudira, Ramesh, Wang, Jiang, Miethke, Alexander, Gandhi, Chandrashekhar R.

“…Liver depleted of hepatic stellate cells (HSCs) is resistant to ischemia/reperfusion‐, concanavalin A‐, and acetaminophen‐induced acute injury. Whether HSCs…”
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Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA‐540 expression by Kumar, Sudhir, Rani, Richa, Karns, Rebekah, Gandhi, Chandrashekhar R.

“…ABSTRACT Levels of augmenter of liver regeneration (ALR), a multifunctional protein, are reduced in steatohepatitis. ALR depletion from ALRflox/flox/Alb‐Cre…”
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