Search Results - "Gandhi, Adarsh S."

Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry by Wohlfarth, Ariane, Gandhi, Adarsh S., Pang, Shaokun, Zhu, Mingshe, Scheidweiler, Karl B., Huestis, Marilyn A.

“…Background PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are…”
Get full text

First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry by Wohlfarth, Ariane, Pang, Shaokun, Zhu, Mingshe, Gandhi, Adarsh S, Scheidweiler, Karl B, Liu, Hua-fen, Huestis, Marilyn A

“…Since the mid-2000s synthetic cannabinoids have been abused as recreational drugs, prompting scheduling of these substances in many countries. To circumvent…”
Get full text

Quantitative analysis of lipids: a higher-throughput LC-MS/MS-based method and its comparison to ELISA by Gandhi, Adarsh S, Budac, David, Khayrullina, Tanzilya, Staal, Roland, Chandrasena, Gamini

“…Lipids such as prostaglandins, leukotrienes and thromboxanes are released as a result of an inflammatory episode in pain (central and peripheral). To measure…”
Get full text

First Characterization of AKB-48 Metabolism, a Novel Synthetic Cannabinoid, Using Human Hepatocytes and High-Resolution Mass Spectrometry by Gandhi, Adarsh S., Zhu, Mingshe, Pang, Shaokun, Wohlfarth, Ariane, Scheidweiler, Karl B., Liu, Hua-fen, Huestis, Marilyn A.

“…Since the federal authorities scheduled the first synthetic cannabinoids, JWH-018 and JWH-073, new synthetic cannabinoids were robustly marketed. N…”
Get full text

High-resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135), using cryopreserved human hepatocytes and assessment of metabolic stability with human liver microsomes by Gandhi, Adarsh S., Wohlfarth, Ariane, Zhu, Mingshe, Pang, Shaokun, Castaneto, Marisol, Scheidweiler, Karl B., Huestis, Marilyn A.

“…N‐(Adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135) is a new synthetic cannabinoid in herbal incense products discussed on Internet drug…”
Get full text

Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens by Wohlfarth, Ariane, Scheidweiler, Karl B, Castaneto, Marisol, Gandhi, Adarsh S, Desrosiers, Nathalie A, Klette, Kevin L, Martin, Thomas M, Huestis, Marilyn A

“…Identifying synthetic cannabinoid designer drug abuse challenges toxicologists and drug testing programs. The best analytical approach for reliably documenting…”
Get more information

Metabolism of RCS-8, a synthetic cannabinoid with cyclohexyl structure, in human hepatocytes by high-resolution MS by Wohlfarth, Ariane, Pang, Shaokun, Zhu, Mingshe, Gandhi, Adarsh S, Scheidweiler, Karl B, Huestis, Marilyn A

“…Since 2008, synthetic cannabinoids are major new designer drugs of abuse. They are extensively metabolized and excreted in urine, but limited human metabolism…”
Get full text

Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS by Gandhi, Adarsh S, Zhu, Mingshe, Pang, Shaokun, Wohlfarth, Ariane, Scheidweiler, Karl B, Huestis, Marilyn A

“…Since 2009, scheduling legislation of synthetic cannabinoids prompted new compound emergence to circumvent legal restrictions…”
Get full text

Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase by Poda, Suresh B, Kobayashi, Masakazu, Nachane, Ruta, Menon, Veena, Gandhi, Adarsh S, Budac, David P, Li, Guiying, Campbell, Brian M, Tagmose, Lena

“…Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway, was identified as a potential therapeutic target for treating neurodegenerative…”
Get more information

Metabolism of synthetic cannabinoids PB-22 and its 5-fIuoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry by Wohlfarth, Ariane, Gandhi, Adarsh S, Pang, Shaokun, Zhu, Mingshe, Scheidweiler, Karl B, Huestis, Marilyn A

“…Background PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are…”
Get full text

Metabolism of midazolam is compromised in inflammation by Gandhi, Adarsh S, Guo, Tao, Hu, Ming, Ghose, Romi

“…Inflammation‐mediated down‐regulation of several hepatic Cytochrome P450 enzymes can have serious implications on drug metabolism leading to variability in…”
Get full text

High‐resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N ‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1 H ‐indole‐3‐carboxamide (STS‐135), using cryopreserved human hepatocytes and assessment of metabolic stability with human liver microsomes by Gandhi, Adarsh S., Wohlfarth, Ariane, Zhu, Mingshe, Pang, Shaokun, Castaneto, Marisol, Scheidweiler, Karl B., Huestis, Marilyn A.

“…N ‐(Adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1 H ‐indole‐3‐carboxamide (STS‐135) is a new synthetic cannabinoid in herbal incense products discussed on Internet drug…”
Get full text