Search Results - "Gancheva R."

The Presence of Monosodium Urate Deposits in the Joints of Patients with Asymptomatic Hyperuricemia is Associated with a Higher Cardiovascular Risk, But Not with More Advanced Kidney Damage by Gancheva R., Koundurdjiev A., Kundurzhiev T., Kolarov Zl, Peteva P., Nikolova M., Koundurdjieva I., Yankova P., Monov S., Marinchev L.

“…To evaluate the association between asymptomatic hyperuricemia, renal damage and cardiovascular events and to investigate whether the presence of monosodium…”
Get full text

Ultrasound Proven Monosodium Urate Crystal Deposits in the Joints are Associated with Smaller Kidney Size, Decreased Intrarenal Blood Flow and Arteriosclerotic Type Vascular Changes by Gancheva, R., Kundurzhiev, T., Kolarov, Zl, Koundurdjiev, A.

“…Abstract Objective: To establish the association between ultrasound (US) burden with articular MSU crystals and renal morphology, blood supply, function and…”
Get full text

The Prevalence of Asymptomatic Hyperuricemia in Patients with or Without Psoriatic Arthritis is Associated with a Similar Cardiovascular Risk by Gancheva R., Kundurzhiev T., Sheitanov I., Petranova Tz, Kolarov Zl, Yankova P., Nikolova M., Kundurdzhiev A.

“…Aim: To investigate the association between cardiovascular burden and monosodium urate (MSU) deposits in the joints of patients with asymptomatic hyperuricemia…”
Get full text

Cardiovascular Risk in Type 2 Diabetic Patients With Asymptomatic Hyperuricemia and Gout by Gancheva, R., Kundurdjiev, A., Kundurdjiev, T., Kolarov, Zl

“…To study the differences in cardiovascular risk between type 2 diabetic and non-diabetic patients with asymptomatic hyperuricemia and gout using the Framingham…”
Get full text

Serum Oxidative Stress Markers are not Associated with Renal and Common Carotid Arteries Arteriosclerotic Vascular Changes in Patients with Gout by Gancheva, R., Kundurdjiev, A., Nikolova, G., Ivanova, M., Kundurdjiev, T., Kolarov, Z., Gadjeva, V.

“…To establish the association between serum levels of reactive oxygen species (ROS) products, nitric oxide (NO) radicals and ascorbate radicals with renal…”
Get full text

Using Dental Pulp Stem Cells for Stroke Therapy by Gancheva, Maria R, Kremer, Karlea L, Gronthos, Stan, Koblar, Simon A

“…Stroke is a leading cause of permanent disability world-wide, but aside from rehabilitation, there is currently no clinically-proven pharmaceutical or…”
Get full text

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics by Dans, Madeline G, Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D, Dawson, Aurelie T, Das, Sujaan, Parkyn Schneider, Molly, Jonsdottir, Thorey K, Gabriela, Mikha, Gancheva, Maria R, Tonkin, Christopher J, Mollard, Vanessa, Goodman, Christopher Dean, McFadden, Geoffrey I, Wilson, Danny W, Rogers, Kelly L, Barry, Alyssa E, Crabb, Brendan S, de Koning-Ward, Tania F, Sleebs, Brad E, Kursula, Inari, Gilson, Paul R

“…With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently…”
Get full text

Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion by Nguyen, William, Dans, Madeline G., Ngo, Anna, Gancheva, Maria R., Romeo, Ornella, Duffy, Sandra, de Koning-Ward, Tania F., Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Wilson, Danny W., Gilson, Paul R., Sleebs, Brad E.

“…The emerging resistance to combination therapies comprised of artemisinin derivatives has driven a need to identify new antimalarials with novel mechanisms of…”
Get full text

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4 by Ashton, Trent D., Calic, Petar P. S., Dans, Madeline G., Ooi, Zi Kang, Zhou, Qingmiao, Palandri, Josephine, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Maity, Bikash Chandra, De, Nirupam, Giannangelo, Carlo, MacRaild, Christopher A., Creek, Darren J., Mao, Emma Y., Gancheva, Maria R., Wilson, Danny W., Chowdury, Mrittika, de Koning-Ward, Tania F., Famodimu, Mufuliat T., Delves, Michael J., Pollard, Harry, Sutherland, Colin J., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.

“…To contribute to the global effort to develop new antimalarial therapies, we previously disclosed initial findings on the optimization of the…”
Get full text

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4 by Ashton, Trent D, Calic, Petar P S, Dans, Madeline G, Ooi, Zi Kang, Zhou, Qingmiao, Loi, Katie, Jarman, Kate E, Palandri, Josephine, Qiu, Deyun, Lehane, Adele M, Maity, Bikash, De, Nirupam, Famodimu, Mufuliat T, Delves, Michael J, Mao, Emma Y, Gancheva, Maria R, Wilson, Danny W, Chowdury, Mrittika, de Koning-Ward, Tania F, Baud, Delphine, Brand, Stephen, Jackson, Paul F, Cowman, Alan F, Sleebs, Brad E

“…The emergence of resistance against current antimalarial treatments has necessitated the need for the development of novel antimalarial chemotypes. Toward this…”
Get full text

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity by Bailey, Brodie L., Nguyen, William, Ngo, Anna, Goodman, Christopher D., Gancheva, Maria R., Favuzza, Paola, Sanz, Laura M., Gamo, Francisco-Javier, Lowes, Kym N., McFadden, Geoffrey I., Wilson, Danny W., Laleu, Benoît, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.

“…[Display omitted] •HT screen identified the triazolopyrimidine class with potent antimalarial activity.•Analogues exhibit potent P. falciparum activity but…”
Get full text

Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity by Ashton, Trent D., Ngo, Anna, Favuzza, Paola, Bullen, Hayley E., Gancheva, Maria R., Romeo, Ornella, Parkyn Schneider, Molly, Nguyen, Nghi, Steel, Ryan W.J., Duffy, Sandra, Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Boddey, Justin A., Wilson, Danny W., Cowman, Alan F., Gilson, Paul R., Sleebs, Brad E.

“…[Display omitted] •The lipophilicity of analogues was intricately linked to asexual parasite activity.•Analogues exhibit potent activity against P. knowlesi…”
Get full text

Specific functions of the motor cortex in reorganizing coordinations during motor training in animals and humans by Ioffe, M E, Massion, J, Schmitz, C, Viallet, F, Gancheva, R

“…The involvement of the motor cortex in learning movements has recently attracted much attention. One aspect of motor learning is the inhibition of innate…”
Get full text