Search Results - "Ganapathi, M. K."

DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy by Chikamori, K, Grozav, A G, Kozuki, T, Grabowski, D, Ganapathi, R, Ganapathi, M K

“…DNA topoisomerase II enzymes regulate essential cellular processes by altering the topology of chromosomal DNA. These enzymes function by creating transient…”
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Downregulation of topoisomerase IIβ in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest by CHIKAMORI, K, HILL, J. E, YEN, A, TANIMOTO, M, GANAPATHI, M. K, GANAPATHI, R, GRABOWSKI, D. R, ZARKHIN, E, GROZAV, A. G, VAZIRI, S. A. J, WANG, J, GUDKOV, A. V, RYBICKI, L. R, BUKOWSKI, R. M

“…Among the topoisomerase (topo) II isozymes (α and β), topo IIβ has been suggested to regulate differentiation. In this study, we examined the role of topo IIβ…”
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Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines by Mackiewicz, A, Speroff, T, Ganapathi, MK, Kushner, I

“…We evaluated the effects of binary combinations of four cytokines on production of the positive acute phase proteins alpha-1 antichymotrypsin, haptoglobin and…”
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Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep 3B cells by Ganapathi, MK, Rzewnicki, D, Samols, D, Jiang, SL, Kushner, I

“…We have previously shown that induction of synthesis of the two major human acute phase proteins, serum amyloid A (SAA) and C-reactive protein (CRP), can be…”
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Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, inhibits induction of acute-phase proteins by interleukin-6 alone or in combination with interleukin-1 in human hepatoma cell lines by GANAPATHI, M. K

“…Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein…”
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Transforming growth factor beta 1 regulates production of acute-phase proteins by Mackiewicz, A, Ganapathi, M K, Schultz, D, Brabenec, A, Weinstein, J, Kelley, M F, Kushner, I

“…We explored the possible role of transforming growth factor beta 1 (TGF-beta), a cytokine that appears to be an important modulator of inflammation and tissue…”
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Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells by AOYAMA, M, MACISAAC, D, BUKOWSKI, R. M, GANAPATHI, M. K

“…Newer therapeutic strategies for the treatment of multiple myeloma have focused on antagonizing the growth-promoting functions of interleukin 6 (IL-6). In this…”
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Heterogeneous nature of the acute phase response. Differential regulation of human serum amyloid A, C-reactive protein, and other acute phase proteins by cytokines in Hep 3B cells by Ganapathi, MK, Schultz, D, Mackiewicz, A, Samols, D, Hu, SI, Brabenec, A, Macintyre, SS, Kushner, I

“…Because a number of different cytokines have been reported to regulate the synthesis of human, murine, and rat acute phase proteins (APP), we studied the…”
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Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines by Ganapathi, M K, May, L T, Schultz, D, Brabenec, A, Weinstein, J, Sehgal, P B, Kushner, I

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Regulation of rabbit acute phase protein biosynthesis by monokines by Mackiewicz, A, Ganapathi, M K, Schultz, D, Samols, D, Reese, J, Kushner, I

“…We defined the acute phase behaviour of a number of rabbit plasma proteins in studies (in vivo) and studied the effects of monokine preparations on their…”
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Cloning and cDNA Sequence of the Dihydrolipoamide Dehydrogenase Component of Human α -ketoacid Dehydrogenase Complexes by Pons, Gabriel, Raefsky-Estrin, Cindy, Carothers, Donna J., Pepin, Ronald A., Javed, Ali A., Jesse, Barry W., Ganapathi, Mahrukh K., Samols, David, Patel, Mulchand S.

“…cDNA clones comprising the entire coding region for human dihydrolipoamide dehydrogenase (dihydrolipoamide:NAD+ oxidoreductase, EC 1.8.1.4) have been isolated…”
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Monokines regulate glycosylation of acute-phase proteins by MACKIEWICZ, A, GANAPATHI, M. K, SCHULTZ, D, KUSHNER, I

“…The acute-phase response to inflammatory stimuli, characterized by increased synthesis of acute-phase proteins (APP), is often accompanied by changes in the…”
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Isolation and characterization of rabbit skeletal muscle protein phosphatases C-I and C-II by Silberman, S R, Speth, M, Nemani, R, Ganapathi, M K, Dombradi, V, Paris, H, Lee, E Y

“…Previous studies have shown that phosphorylase phosphatase can be isolated from rabbit liver and bovine heart as a form of Mr approximately 35,000 after an…”
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Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity by Chikamori, Kenichi, Grabowski, Dale R, Kinter, Michael, Willard, Belinda B, Yadav, Satya, Aebersold, Ruedi H, Bukowski, Ronald M, Hickson, Ian D, Andersen, Anni H, Ganapathi, Ram, Ganapathi, Mahrukh K

“…Topoisomerases alter DNA topology and are vital for the maintenance of genomic integrity. Topoisomerases I and II are also targets for widely used antitumor…”
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Roles of NF-κB and 26 S Proteasome in Apoptotic Cell Death Induced by Topoisomerase I and II Poisons in Human Nonsmall Cell Lung Carcinoma by Tabata, Masahiro, Tabata, Rika, Grabowski, Dale R., Bukowski, Ronald M., Ganapathi, Mahrukh K., Ganapathi, Ram

“…Activation of signaling pathways after DNA damage induced by topoisomerase (topo) poisons can lead to cell death by apoptosis. Treatment of human nonsmall cell…”
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Isolation and characterization of a high molecular weight protein phosphatase from rabbit skeletal muscle by Paris, H, Ganapathi, M K, Silberman, S R, Aylward, J H, Lee, E Y

“…A high molecular weight protein phosphatase (phosphatase H-II) was isolated from rabbit skeletal muscle. The enzyme had a Mr = 260,000 as determined by gel…”
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Dephosphorylation of rabbit skeletal muscle phosphorylase kinase. Evidence against the operation of the "second-site phosphorylation" mechanism of regulation by Ganapathi, M K, Silberman, S R, Paris, H, Lee, E Y

“…The dephosphorylation of rabbit skeletal muscle phosphorylase kinase was studied using two purified rabbit skeletal muscle protein phosphatases. The first…”
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Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine by Ganapathi, M K, Mackiewicz, A, Samols, D, Brabenec, A, Kushner, I, Schultz, D, Hu, S I

“…Induction of C-reactive protein (CRP) by conditioned medium from lipopolysaccharide-stimulated human monocytes in two human hepatoma-cell lines, Hep 3B and…”
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Altered expression and activity of topoisomerases during all-trans retinoic acid-induced differentiation of HL-60 cells by AOYAMA, M, GRABOWSKI, D. R, ISAACS, R. J, KRIVACIC, K. A, RYBICKI, L. A, BUKOWSKI, R. M, GANAPATHI, M. K, HICKSON, L. D, GANAPATHI, R

“…Regulation of topoisomerase II (TOPO II) isozymes alpha and beta is influenced by the growth and transformation state of cells. Using HL-60 cells induced to…”
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Induction of succinyl-coenzyme A:3-oxoacid coenzyme A-transferase during differentiation of 3T3-L1 cells by Ganapathi, M K, Raefsky, C, Patel, M S

“…Differentiation of confluent 3T3-L1 preadipocytes to adipocytes in the presence of dexamethasone and 1-methyl-3-isobutylxanthine for 7 days resulted in a…”
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