Search Results - "Gan, Yichao"

Alternative approaches to target Myc for cancer treatment by Wang, Chen, Zhang, Jiawei, Yin, Jie, Gan, Yichao, Xu, Senlin, Gu, Ying, Huang, Wendong

“…The Myc proto-oncogene family consists of three members, C-MYC , MYCN , and MYCL , which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and…”
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Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells by Zhang, Jiawei, Gan, Yichao, Li, Hongzhi, Yin, Jie, He, Xin, Lin, Liming, Xu, Senlin, Fang, Zhipeng, Kim, Byung-wook, Gao, Lina, Ding, Lili, Zhang, Eryun, Ma, Xiaoxiao, Li, Junfeng, Li, Ling, Xu, Yang, Horne, David, Xu, Rongzhen, Yu, Hua, Gu, Ying, Huang, Wendong

“…Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most…”
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CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine by Gu, Ying, Chen, Ting, Meng, Zhipeng, Gan, Yichao, Xu, Xiaohua, Lou, Guiyu, Li, Hongzhi, Gan, Xiaoxian, Zhou, Hong, Tang, Jinfen, Xu, Genbo, Huang, Liansheng, Zhang, Xiaohong, Fang, Yongming, Wang, Kai, Zheng, Shu, Huang, Wendong, Xu, Rongzhen

“…Bcr-Abl tyrosine kinase inhibitors (TKIs) have been a remarkable success for the treatment of Ph+ chronic myeloid leukemia (CML). However, a significant…”
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Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy by Lin, Liming, Tao, Jingjing, Meng, Ying, Gan, Yichao, He, Xin, Li, Shu, Zhang, Jiawei, Gao, Feiqiong, Xin, Dijia, Wang, Luyao, Fan, Yili, Chen, Boxiao, Lu, Zhimin, Xu, Yang

“…Although significant progress has been made in the development of novel targeted drugs for the treatment of acute myeloid leukemia (AML) in recent years,…”
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Tubeimoside-2 Triggers Methuosis in Hepatocarcinoma Cells through the MKK4-p38α Axis by Gan, Yichao, Wang, Chen, Chen, Yunyun, Hua, Linxin, Fang, Hui, Li, Shu, Chai, Shoujie, Xu, Yang, Zhang, Jiawei, Gu, Ying

“…Liver cancer, consisting mainly of hepatocellular carcinoma, is the third leading cause of cancer-related mortality worldwide. Despite advances in targeted…”
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Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study by Qiu, Kaijie, Xia, Qing, Chen, Hao, Ye, Qiong, Mao, Haixiang, Tian, Mei, Gan, Yichao, Huang, Qinyuan, Wang, Haibiao, Duan, Shiwei

“…Hepatocellular carcinoma (HCC), ranking as the seventh most prevalent cancer worldwide, poses a significant health challenge. Actinidia chinensis Planch Root…”
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Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice by Meng, Zhipeng, Wang, Xiaoqiong, Gan, Yichao, Zhang, Yunfeng, Zhou, Hong, Ness, Carl Van, Wu, Jun, Lou, Guiyu, Yu, Hua, He, Chao, Xu, Rongzhen, Huang, Wendong

“…Background & Aims Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation. We previously showed that farnesoid…”
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Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer by Zhu, Yinghui, He, Xin, Li, Shu, Gan, Yichao, Li, Zheng, Wang, Hanying, Dong, Haojie, Zhang, Lei, Xue, Sheng‐Li, Xu, Yang, Li, Ling

“…CSNK2A1) or CDK family members was higher in F relative to R specimens (Figure 2C; Table S4). [...]DEPMAP analysis revealed that depleting CDK family members…”
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DMSeqNet-mBART: A state-of-the-art Adaptive-DropMessage enhanced mBART architecture for superior Chinese short news text summarization by Cao, Kangjie, Cheng, Weijun, Hao, Yiya, Gan, Yichao, Gao, Ruihuan, Zhu, Junxu, Wu, Jinyao

“…Mandarin Chinese, a globally prevalent language, boasts an abundance of regularly refreshed short news texts accessible online. Consequently, devising concise…”
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Effect of a single nucleotide polymorphism (rs2910164) in miR-146a on COX-2 expression and apoptosis in colon cancer patients treated with celecoxib by Xu, Fei, Yang, Jie, Gan, Yichao, Gai, Kai

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DAP10 Predicted the Outcome of Pediatric B-Cell Acute Lymphoblastic Leukemia and Was Associated with the T-Cell Exhaustion by Shi, Nana, Luo, Yingwan, Xu, Ying, Liang, Junyu, Ma, An, Gan, Yichao, Wu, Bowen

“…B-cell acute lymphoblastic leukemia is the most common malignant tumor in children. About 10–15% of patients will relapse with a 5-year OS of 57.5% for the…”
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The diagnostic and prognostic value of cell division cycle associated gene family in Hepatocellular Carcinoma by Wu, Bowen, Huang, Yu, Luo, Yingwan, Ma, An, Wu, Zhaoxing, Gan, Yichao, Xu, Ying, Xu, Rongzhen

“…Cell division cycle associated (CDCA) gene family plays an important role in cells. However, some researchers revealed that overexpression of CDCAs might…”
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Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²⁺/calmodulin-dependent protein kinase II by Meng, Zhipeng, Li, Tao, Ma, Xiaoxiao, Wang, Xiaoqiong, Van Ness, Carl, Gan, Yichao, Zhou, Hong, Tang, Jinfen, Lou, Guiyu, Wang, Yafan, Wu, Jun, Yen, Yun, Xu, Rongzhen, Huang, Wendong

“…Liver cancer is the third leading cause of cancer deaths worldwide but no effective treatment toward liver cancer is available so far. Therefore, there is an…”
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Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma by Li, Shu, He, Xin, Gan, Yichao, Zhang, Jiawei, Gao, Feiqiong, Lin, Limin, Qiu, Xi, Yu, Teng, Zhang, Xuzhao, Chen, Panpan, Tong, Jiefeng, Qian, Wenbin, Xu, Yang

“…NL101 has shown activities against multiple myeloma and acute myeloid leukemia, but its anti-lymphoma activity remains unknown. The transcription factor c-Myc…”
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Identification of the novel Np17 oncogene in human leukemia by Wu, Bowen, Gan, Yichao, Xu, Ying, Wu, Zhaoxing, Xu, Ganyu, Wang, Ping, Wang, Chen, Meng, Zhipeng, Li, Mengyuan, Zhang, Jiawei, Zhuang, Haifeng, Zhang, Xuzhao, Yang, Linlin, Li, Jinfan, Gan, Xiaoxian, Yu, Xiaofang, Huang, Wendong, Gu, Ying, Xu, Rongzhen

“…We previously defined the HERV-K Np9 as a viral oncogene. Here we report the discovery of a novel oncogene, Np17, which is homologous to the viral Np9 gene and…”
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Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a by Jiang, Xudong, Wu, Zhaoxing, Lu, Xiaoya, Zhang, Xuzhao, Yu, Qingfeng, Gan, Yichao, Wu, Bowen, Xu, Ying, Zheng, Weiwei, Zhang, Lei, Xu, Fei, Ma, An, Gan, Xiaoxian, Huang, Silvia, Yu, Xiaofang, Huang, Wendong, Xu, Rongzhen

“…Ca /calmodulin-dependent protein kinase II γ (CaMKIIγ) can regulate the proliferation and differentiation of myeloid leukemia cells and accelerate chronic…”
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Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue by Gu, Ying, Zhou, Hong, Gan, Yichao, Zhang, Jiawei, Chen, Jianghua, Gan, Xiaoxian, Li, Hongzhi, Zheng, Weiwei, Meng, Zhipeng, Ma, Xiaoxiao, Wang, Xichun, Xu, Xiaohua, Xu, Ganyu, Lu, Xiaoya, Liang, Yun, Zhang, Xuzhao, Lu, Xinliang, Huang, Wendong, Xu, Rongzhen

“…As phospho-eIF4E (p-eIF4E), unlike total eIF4E (t-eIF4E) essential for normal cells, is specifically required by cancer cells, it is an attractive, yet…”
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Identification of a novel RNA giant nuclear body in cancer cells by Zhou, Hong, Zhang, Jiawei, Gu, Ying, Gan, Xiaoxian, Gan, Yichao, Zheng, Weiwei, Kim, Byung-Wook, Xu, Xiaohua, Lu, Xiaoya, Dong, Qi, Zheng, Shu, Huang, Wendong, Xu, Rongzhen

“…Constitutive synthesis of oncogenic mRNAs is essential for maintaining the uncontrolled growth of cancer cells. However, little is known about how these mRNAs…”
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Optimization Study of KNN Classification Algorithm on Large-Scale Datasets: Real-Time Optimization Strategy Based on Balanced KD Tree and Multi-threaded Parallel Computing by Cao, Kangjie, Wu, Jinyao, Huang, Qianhang, Gan, Yichao

“…The K-Nearest Neighbors (KNN) algorithm is a classical supervised learning method widely used in classification and regression problems. However, the KNN…”
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Convolutional Neural Network (CNN) for Building Energy Efficiency Analysis, Prediction, and Real-time Adjustment Strategies by Liu, Bin, Cao, Yujian, Gan, Yichao, Huang, Qianhang, Zeng, Tong, Zhang, Jing, Cao, Kangjie

“…In the era of sustainable development, building energy efficiency stands out as a pivotal concern, given the significant energy consumption attributed to…”
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