Search Results - "Gan, Samuel"

Superantigen Recognition and Interactions: Functions, Mechanisms and Applications by Deacy, Anthony M, Gan, Samuel Ken-En, Derrick, Jeremy P

“…Superantigens are unconventional antigens which recognise immune receptors outside their usual recognition sites e.g. complementary determining regions (CDRs),…”
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Social anxiety mediates workplace incivility and work engagement by Gan, Samuel Ken-En, Zeng, Yusong, Wang, Zihan

“…The average working person spends between 35 and 60 h a week in the workplace, making it an influential place for mental well-being and a place for…”
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Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells by Karagiannis, Panagiotis, Singer, Josef, Hunt, James, Gan, Samuel K. E, Rudman, Sarah M, Mechtcheriakova, Diana, Knittelfelder, Regina, Daniels, Tracy R, Hobson, Philip S, Beavil, Andrew J, Spicer, James, Nestle, Frank O, Penichet, Manuel L, Gould, Hannah J, Jensen-Jarolim, Erika, Karagiannis, Sophia N

“…Trastuzumab (Herceptin®), a humanized IgG1 antibody raised against the human epidermal growth factor receptor 2 (HER2/neu), is the main antibody in clinical…”
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A comparison and optimization of methods and factors affecting the transformation of Escherichia coli by Chan, Weng-Tat, Verma, Chandra S, Lane, David P, Gan, Samuel Ken-En

“…DNA manipulation routinely requires competent bacteria that can be made using one of numerous methods. To determine the best methods, we compared four commonly…”
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Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness by Yeo, Joshua Yi, Gan, Samuel Ken-En

“…2014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020-2021…”
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Spectrophotometer on-the-go: The development of a 2-in-1 UV–Vis portable Arduino-based spectrophotometer by Poh, Jun-Jie, Wu, Wei-Ling, Goh, Nicholas Wei-Jie, Tan, Samuel Ming-Xuan, Gan, Samuel Ken-En

“…[Display omitted] •The assembly and functionality of a portable UV–Vis spectrophotometer using Arduino Nano microcontroller, OSD5.8-7Q Full Spectrum Si…”
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Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab by Samsudin, Firdaus, Yeo, Joshua Yi, Gan, Samuel Ken-En, Bond, Peter J

“…The therapeutic potential of immunoglobulin M (IgM) is of considerable interest in immunotherapy due to its complement-activating and cell-agglutinating…”
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Design and Development of a Low Cost, Non-Contact Infrared Thermometer with Range Compensation by Goh, Nicholas Wei-Jie, Poh, Jun-Jie, Yeo, Joshua Yi, Aw, Benjamin Jun-Jie, Lai, Szu Cheng, Cheng, Jayce Jian Wei, Tan, Christina Yuan Ling, Gan, Samuel Ken-En

“…Fever is a common symptom of many infections, e.g., in the ongoing COVID-19 pandemic, keeping monitoring devices such as thermometers in constant demand…”
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Editorial: Understanding and Engineering Antibody-Superantigen Interactions by Gan, Samuel Ken-En, Derrick, Jeremy P, Fraternali, Franca

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Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs by Su, Chinh Tran-To, Koh, Darius Wen-Shuo, Gan, Samuel Ken-En

“…HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this…”
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Understanding the T cell immune response in SARS coronavirus infection by Janice Oh, Hsueh-Ling, Ken-En Gan, Samuel, Bertoletti, Antonio, Tan, Yee-Joo

“…The severe acute respiratory syndrome (SARS) epidemic started in late 2002 and swiftly spread across 5 continents with a mortality rate of around 10%. Although…”
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The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance by Yeo, Joshua Yi, Goh, Ghin-Ray, Su, Chinh Tran-To, Gan, Samuel Ken-En

“…The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance, from the development of vaccines to…”
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Religiosity, Theism, Perceived Social Support, Resilience, and Well-Being of University Undergraduate Students in Singapore during the COVID-19 Pandemic by Gan, Samuel Ken-En, Wong, Sibyl Weang-Yi, Jiao, Peng-De

“…The COVID-19 pandemic infection control measures severely impacted mental well-being, allowing insight into possible protective parameters. With religion…”
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Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery by Phua, Ser-Xian, Chan, Kwok-Fong, Su, Chinh Tran-To, Poh, Jun-Jie, Gan, Samuel Ken-En

“…The reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the…”
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Effects of different delivery modes on teaching biomedical science practical skills in higher education during the 2021 pandemic measures by Heng, Zealyn Shi‐Lin, Koh, Darius Wen‐Shuo, Yeo, Joshua Yi, Ooi, Chui‐Ping, Gan, Samuel Ken‐En

“…The COVID‐19 pandemic related measures had augmented the rise of online education. While online teaching had mitigated the negative impacts from educational…”
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Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types by Yeo, Joshua Yi, Koh, Darius Wen-Shuo, Yap, Ping, Goh, Ghin-Ray, Gan, Samuel Ken-En

“…While drug resistant mutations in HIV-1 are largely credited to its error prone HIV-1 RT, the time point in the infection cycle that these mutations can arise…”
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The influence of variable-heavy chain families on IgG2, 3, 4, FcγRs and B-cell superantigens protein G and L binding using biolayer interferometry by Deacy, Anthony M, Gan, Samuel Ken-En

“…Abstract As the most abundant immunoglobulin in blood and the most common human isotype used for therapeutic monoclonal antibodies, the engagement and…”
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Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy by Lua, Wai-Heng, Su, Chinh Tran-To, Yeo, Joshua Yi, Poh, Jun-Jie, Ling, Wei-Li, Phua, Ser-Xian, Gan, Samuel Ken-En

“…Variable heavy chain (VH) family frameworks (FWRs) have been reported to affect antibody receptor and superantigen binding; however, such effects in IgE remain…”
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Probability of change in life: Amino acid changes in single nucleotide substitutions by Chan, Kwok-Fong, Koukouravas, Stelios, Yeo, Joshua Yi, Koh, Darius Wen-Shuo, Gan, Samuel Ken-En

“…Mutations underpin the processes in life, be it beneficial or detrimental. While mutations are assumed to be random in the bereft of selection pressures, the…”
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The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding by Lua, Wai-Heng, Ling, Wei-Li, Yeo, Joshua Yi, Poh, Jun-Jie, Lane, David Philip, Gan, Samuel Ken-En

“…Current therapeutic antibodies such as Trastuzumab, are typically of the blood circulatory IgG1 class (Cκ/ CHγ1). Due to the binding to Her2 also present on…”
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