Search Results - "Gan, Kathlyn J"

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment by Gan, Kathlyn J., Südhof, Thomas C.

“…Aging drives a progressive decline in cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the risk for…”
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SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins by Gan, Kathlyn J, Südhof, Thomas C

“…Emerging evidence supports roles for secreted extracellular matrix proteins in boosting synaptogenesis, synaptic transmission, and synaptic plasticity. SPARCL1…”
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Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses by Patzke, Christopher, Brockmann, Marisa M., Dai, Jinye, Gan, Kathlyn J., Grauel, M. Katharina, Fenske, Pascal, Liu, Yu, Acuna, Claudio, Rosenmund, Christian, Südhof, Thomas C.

“…Neuromodulators bind to pre- and postsynaptic G protein-coupled receptors (GPCRs), are able to quickly change intracellular cyclic AMP (cAMP) and Ca2+ levels,…”
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The Ultraviolet Opsin Is the First Opsin Expressed during Retinal Development of Salmonid Fishes by Cheng, Christiana L, Gan, Kathlyn J, Flamarique, Inigo Novales

“…To determine the spatial and temporal progression of opsin appearance during retinal development of salmonid fishes (genus Oncorhynchus and Salmo). Reverse…”
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Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons by Gan, Kathlyn J, Silverman, Michael A

“…Disruption of fast axonal transport (FAT) and intracellular Ca(2+) dysregulation are early pathological events in Alzheimer's disease (AD). Amyloid-β oligomers…”
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Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons by Ramser, Elisa M, Gan, Kathlyn J, Decker, Helena, Fan, Emily Y, Suzuki, Matthew M, Ferreira, Sergio T, Silverman, Michael A

“…Disruption of fast axonal transport (FAT) is an early pathological event in Alzheimer's disease (AD). Soluble amyloid-β oligomers (AβOs), increasingly…”
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Atlas stumbled: Kinesin light chain‐1 variant E triggers a vicious cycle of axonal transport disruption and amyloid‐β generation in Alzheimer's disease by Gan, Kathlyn J, Morihara, Takashi, Silverman, Michael A

“…Substantial evidence implicates fast axonal transport (FAT) defects in neurodegeneration. In Alzheimer's disease (AD), it is controversial whether transport…”
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Thyroid hormone accelerates opsin expression during early photoreceptor differentiation and induces opsin switching in differentiated TRα‐expressing cones of the salmonid retina by Gan, Kathlyn J., Novales Flamarique, Iñigo

“…Thyroid hormone and its receptors (TRs) regulate photoreceptor differentiation and visual pigment protein (opsin) expression in the retinas of several…”
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Thyroid Hormone Induces a Time-Dependent Opsin Switch in the Retina of Salmonid Fishes by Cheng, Christiana L, Gan, Kathlyn J, Flamarique, Inigo Novales

“…To determine the role of thyroid hormone in inducing the UV (SWS1)-to-blue (SWS2) opsin switch in the retina of two salmonid fishes, the coho salmon…”
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Imaging organelle transport in primary hippocampal neurons treated with amyloid-β oligomers by Gan, Kathlyn J, Silverman, Michael A

“…We describe a strategy for fluorescent imaging of organelle transport in primary hippocampal neurons treated with amyloid-β (Aβ) peptides that cause…”
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Dendritic and axonal mechanisms of Ca 2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons by Gan, Kathlyn J., Silverman, Michael A.

“…Disruption of fast axonal transport (FAT) and intracellular Ca 2+ dysregulation are early pathological events in Alzheimer's disease (AD). Amyloid-β oligomers…”
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Chapter 21. Imaging organelle transport in primary hippocampal neurons treated with amyloid- beta oligomers by Gan, Kathlyn J, Silverman, Michael A

“…We describe a strategy for fluorescent imaging of organelle transport in primary hippocampal neurons treated with amyloid- beta (A beta ) peptides that cause…”
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Atlas stumbled: Kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-[beta] generation in Alzheimer's disease by Gan, Kathlyn J, Morihara, Takashi, Silverman, Michael A

“…Substantial evidence implicates fast axonal transport (FAT) defects in neurodegeneration. In Alzheimer's disease (AD), it is controversial whether transport…”
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Thyroid hormone regulates opsin expression in the retina of salmonid fishes by Gan, Kathlyn J eanne

“…Vertebrate colour vision is mediated by cone photoreceptors, which express visual pigment proteins (opsins). During salmonid retinal development, cone opsin…”
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