Search Results - "Gan, Huoqun"
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B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
Published in Nature communications (02-01-2020)“…Short-chain fatty acids (SCFAs) butyrate and propionate are metabolites from dietary fiber's fermentation by gut microbiota that can affect differentiation or…”
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B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
Published in Science advances (01-04-2020)“…Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM), critical processes…”
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Sirt1-mediated metabolic modulation of Aicda , class-switch DNA recombination and somatic hypermutation
Published in The Journal of immunology (1950) (01-05-2018)“…Abstract Maturation of the antibody response entails Ig somatic hypermutation (SHM) and class switch DNA recombination (CSR). SHM and CSR perfect the…”
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Sirt1 modulates immunoglobulin class switch DNA recombination and somatic hypermutation by regulating B lymphocyte Aicda expression through NF-kB deacetylation
Published in The Journal of immunology (1950) (01-05-2017)“…Abstract Maturation of the antibody response entails Ig class switch DNA recombination (CSR) and somatic hypermutation (SHM), which perfect the antigen-binding…”
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B cell-intrinsic epigenetic modulation of local and systemic antibody response by gut microbiota through catabolic short-chain fatty acids
Published in The Journal of immunology (1950) (01-05-2018)“…Abstract Immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM), as initiated by AID, and plasma cell differentiation, as mediated…”
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B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching
Published in The Journal of immunology (1950) (01-03-2020)“…Upon activation by CD40 or TLR signaling, B lymphocytes activate NF-κB to induce activation-induced cytidine deaminase and, therefore, Ig class switch DNA…”
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Correction: B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching
Published in The Journal of immunology (1950) (01-06-2020)Get full text
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